DOI QR코드

DOI QR Code

Bacteremia caused by Leuconostoc species : 6-case series

  • Oh, Ki Jong (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Jung, Dong Sik (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Ko, Kwan Soo (Department of Molecular Cell Biology, Sungkyunkwan University College of Medicine) ;
  • Lee, Ho Jin (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Park, Jun Yong (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Hyuck (Department of Internal Medicine, Dong-A University College of Medicine)
  • Received : 2016.07.29
  • Accepted : 2016.10.19
  • Published : 2018.12.31

Abstract

Leuconostoc species are Gram-positive coccobacilli and are used in dairy products and are intrinsically resistant to vancomycin. Leuconostoc infections are rare in humans, usually occurring in immune-compromised patients. We describe 6 patients with Leuconostoc bacteremia at Dong-A university hospital between 1990 and 2015. One isolate (L. lactis) was identified to species level using 16S rRNA gene sequencing analysis. All patients had underlying diseases and 5 patients underwent procedures that interrupted the normal integumentary defense. Four patients died within 30 days after being identified as carrying Leuconostoc species.

Keywords

References

  1. Templin KS, Crook T, Riley T 3rd, Whitener C, Aber RC. Spontaneous bacterial peritonitis and bacteremia due to Leuconostoc species in a patient with end-stage liver disease; a case report. J Infect 2001;43:155-7. https://doi.org/10.1053/jinf.2001.0873
  2. Handwerger S, Horowitz H, Coburn K, Kolokathis A, Wormser G. Infection due to Leuconostoc species : six cases and review. Rev Infect Dis1990;12:602-10. https://doi.org/10.1093/clinids/12.4.602
  3. Kim GY, Kim MH, Park SY, Park MJ, Suh JT, Lee HJ. A case of bacteremia caused by Leuconostoc lactis identified by 16S rRNA sequencing. Korean J Clin Microbiol 2006;9:137-41.
  4. Shin J, Her M, Moon C, Kim D, Lee S, Jung S. Leuconostoc bacteremia in a patient with amyloidosis secondary to rheumatoid arthritis and tuberculosis arthritis. Mod Rheumatol 2011;21:691-5. https://doi.org/10.3109/s10165-011-0465-0
  5. Shin KS, Han KD, Hong SB. Septicemia caused by Leuconostoc lactis with intrinsic toleranceto vancomycin in a patient with biliary stent. Korean Journal of Biomedical Laboratory Sciences 2013;19:280-3.
  6. Lee MR, Huang YT, Lee PI, Liao CH, Lai CC, Lee LN, et al. Healthcare-associated bacteremia caused by Leuconostoc species at a university hospital in Taiwan between 1995 and 2008. J Hosp Infect 2011;78:45-9. https://doi.org/10.1016/j.jhin.2010.11.014
  7. Moise-Broder PA, Sakoulas G, Eliopoulos GM, Schentag JJ, Forrest A, Moellering RC Jr. Accessory gene regulator group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy. Clin Infect Dis 2004;38:1700-5. https://doi.org/10.1086/421092
  8. Coovadia YM, Solwa Z, van Den Ende J. Potential pathogenicity of Leuconostoc. Lancet 1988;1:306.
  9. Swenson JM, Facklam RR, Thornsberry C. Antimicrobial susceptibility of vancomycin- resistant Leuconostoc, Pediococcus, and Lactobacillus species. Antimicrob Agents Chemother 1990;34:543-9. https://doi.org/10.1128/AAC.34.4.543
  10. Jordan JA and Durso MB. Comparison of 16S rRNA gene PCR and BACTEC 9240 for detection of neonatal bacteremia. J Clin Microbiol 2000;38:2574-8.
  11. Sleigh J, Cursons R, Pine ML. Detection of bacteraemia in critically ill patients using 16S rDNA polymerase chain reaction and DNA sequencing. Intensive Care Med 2001;27:1269-73. https://doi.org/10.1007/s001340100981