Current Applied Physics

  • 제18권11호
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  • Pages.1294-1299
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  • 2018
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  • 1567-1739(pISSN)
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  • 1567-1739(eISSN)
한국물리학회 (Korean Physical Society)
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DOI QR코드

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Synthesis and characterization of doxorubicin hydrochloride drug molecule-intercalated DNA nanostructures

  • Gnapareddy, Bramaramba (Department of Physics and Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University) ;
  • Deore, Pragati Madhukar (Department of Physics and Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University) ;
  • Dugasani, Sreekantha Reddy (Department of Physics and Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University) ;
  • Kim, Seungjae (Department of Physics and Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University) ;
  • Park, Sung Ha (Department of Physics and Sungkyunkwan Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University)
  • 투고 : 2018.03.18
  • 심사 : 2018.07.11
  • 발행 : 2018.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

In this paper, we demonstrate the feasibility of constructing DNA nanostructures (i.e. DNA rings and double-crossover (DX) DNA lattices) with appropriate doxorubicin hydrochloride (DOX) concentration and reveal significant characteristics for specific applications, especially in the fields of biophysics, biochemistry and medicine. DOX-intercalated DNA rings and DX DNA lattices are fabricated on a given substrate using the substrateassisted growth method. For both DNA rings and DX DNA lattices, phase transitions from crystalline to amorphous, observed using atomic force microscopy (AFM) occurred above a certain concentration of DOX (at a critical concentration of DOX, $30{\mu}M$ of $[DOX]_C$) at a fixed DNA concentration. Additionally, the coverage percentage of DNA nanostructures on a given substrate is discussed in order to understand the crystal growth mechanism during the course of annealing. Lastly, we address the significance of optical absorption and photoluminescence characteristics for determining the appropriate DOX binding to DNA molecules and the energy transfer between DOX and DNA, respectively. Both measurements provide evidence of DOX doping and $[DOX]_C$ in DNA nanostructures.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation (NRF)

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피인용 문헌

  1. Optoelectronic properties of DNA thin films implanted with titania nanoparticle-coated multiwalled carbon nanotubes vol.9, pp.1, 2018, https://doi.org/10.1063/1.5063446