DOI QR코드

DOI QR Code

Paradoxical Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus Infection: Matching Clinical Findings with MRI Findings

인간면역결핍바이러스 감염환자에서 역설적 크립토코쿠스 수막염 면역재구성 염증증후군: 임상 소견들과 자기공명영상 소견들의 대조

  • Moon, Sungjun (Department of Radiology, Kyungpook National University Hospital) ;
  • Hahm, Myong Hun (Department of Radiology, School of Medicine, Kyungpook National University)
  • 문성준 (경북대학교병원 영상의학과) ;
  • 함명훈 (경북대학교 의과대학 영상의학교실)
  • Received : 2018.04.26
  • Accepted : 2018.07.25
  • Published : 2018.12.01

Abstract

There are two forms of cryptococcal meningitis immune reconstitution inflammatory syndrome (CM-IRIS): paradoxical CM-IRIS and unmasking CM-IRIS. It is important to distinguish paradoxical CM-IRIS and CM relapse because mortality of CM-IRIS is higher than that of CM without IRIS, and paradoxical CM-IRIS and CM relapse requires different treatment. We report a case of paradoxical CM-IRIS that well matches the clinical findings with MR findings during three years follow-up of a HIV infected patient and new MRI finding is also introduced to help distinguish them.

크립토코쿠스 수막염 면역재구성 염증증후군은 역설적 크립토코쿠스 수막염 면역재구성 염증증후군과 증상이 드러나는 크립토코쿠스 수막염 면역재구성 염증증후군의 두 가지 형태가 있다. 역설적 크립토코쿠스 수막염 면역재구성 염증증후군과 크립토코쿠스 수막염 재발을 구별하는 것은 중요하다. 왜냐하면 면역재구성 염증증후군 없는 크립토코쿠스 수막염보다 면역재구성 염증증후군이 있는 크립토 코쿠스 수막염의 사망율이 더 높고, 역설적 크립토코쿠스 수막염 면역재구성 염증증후군과 크립토코쿠스 수막염 재발은 다른 치료를 요구하기 때문이다. 우리는 인간면역결핍바이러스 감염환자의 3년의 추적기간 동안 임상 소견과 자기공명영상 소견이 잘 대조된 역설적 크립토코쿠스 수막염 면역재구성 염증증후군의 사례와 감별에 도움이 되는 새로운 자기공명영상 소견을 보고하고자 한다.

Keywords

References

  1. Haddow LJ, Colebunders R, Meintjes G, Lawn SD, Elliott JH, Manabe YC, et al. Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions. Lancet Infect Dis 2010;10:791-802 https://doi.org/10.1016/S1473-3099(10)70170-5
  2. Bahr N, Boulware DR, Marais S, Scriven J, Wilkinson RJ, Meintjes G. Central nervous system immune reconstitution inflammatory syndrome. Curr Infect Dis Rep 2013;15:583-593 https://doi.org/10.1007/s11908-013-0378-5
  3. Boulware DR, Meya DB, Bergemann TL, Wiesner DL, Rhein J, Musubire A, et al. Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study. PLoS Med 2010;7:e1000384 https://doi.org/10.1371/journal.pmed.1000384
  4. Sungkanuparph S, Filler SG, Chetchotisakd P, Pappas PG, Nolen TL, Manosuthi W, et al. Cryptococcal immune reconstitution inflammatory syndrome after antiretroviral therapy in AIDS patients with cryptococcal meningitis: a prospective multicenter study. Clin Infect Di s 2009;49:931-934 https://doi.org/10.1086/605497
  5. Boulware DR, Bonham SC, Meya DB, Wiesner DL, Park GS, Kambugu A, et al. Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome. J Infect Dis 2010;202:962-970 https://doi.org/10.1086/655785
  6. The Southern African HIV Clinicians Society. Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update. South Afr J HIV Med 2013;14:76-86 https://doi.org/10.4102/sajhivmed.v14i2.82
  7. Musubire AK, Boulware DR, Meya DB, Rhein J. Diagnosis and management of cryptococcal relapse. J AIDS Clin Res 2013;Suppl 3:S3-003
  8. Katchanov J, Branding G, Jefferys L, Arasteh K, Stocker H, Siebert E. Neuroimaging of HIV-associated cryptococcal meningitis: comparison of magnetic resonance imaging findings in patients with and without immune reconstitution. Int J STD AIDS 2016;27:110-117 https://doi.org/10.1177/0956462415574633
  9. Post MJ, Thurnher MM, Clifford DB, Nath A, Gonzalez RG, Gupta RK, et al. CNS-immune reconstitution inflammatory syndrome in the setting of HIV infection, part 1: overview and discussion of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome and cryptococcal-immune reconstitution inflammatory syndrome. AJNR Am J Neuroradiol 2013;34:1297-1307 https://doi.org/10.3174/ajnr.A3183