대한영상의학회지 (Journal of the Korean Society of Radiology)

  • 제79권4호
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  • Pages.196-203
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  • 2018
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  • 1738-2637(pISSN)
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  • 2951-0805(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
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35세 이하 젊은 여성의 유방암: 자기공명영상 소견과 임상병리학적 및 면역조직화학 특성과의 상관관계

Breast Cancer in Women Younger than 35-Years-Old: Correlation of MRI Findings with Clinicopathological Features and Immunohistochemical Subtypes

  • 이세형 (가톨릭대학교 의과대학 성빈센트병원 영상의학과) ;
  • 강봉주 (가톨릭대학교 의과대학 서울성모병원 영상의학과) ;
  • 안영이 (가톨릭대학교 의과대학 성빈센트병원 영상의학과)
  • Lee, Sae Hyung (Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic Unversity of Korea) ;
  • Kang, Bong Joo (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • An, Yeong Yi (Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic Unversity of Korea)
  • 투고 : 2018.02.23
  • 심사 : 2018.06.13
  • 발행 : 2018.10.01
⟨ 이전 논문 다음 논문 ⟩

초록

목적: 35세 이하 젊은 유방암 환자의 자기공명영상 소견을 알아보고 조직 병리학적 예후 인자와의 상관관계를 알아보고자 하였다. 대상과 방법: 2009년 1월부터 2013년 12월까지 본원에서 조직학적으로 유방암이 확진된 35세 이하 환자 중 유방 자기공명영상 촬영을 시행한 91명을 대상으로 하였다. 전자의무기록을 이용해 얻어진 임상 및 조직병리학적 예후 인자와 후향적으로 분석된 자기공명영상 판독 소견과의 관계를 통계적으로 비교 분석하였다. 결과: 가장 흔한 자기공명영상 소견은 종괴의 불규칙한 모양(53.7%), 불규칙한 경계(53.7%), 비균질한 조영증강(53.8%), Type 3 조영증강 패턴(57.1%)이었다. 다변량 분석에서 종괴의 테두리 조영증강이 높은 조직 등급(p = 0.001), 에스트로겐 수용체 음성(p < 0.001), 프로게스테론 수용체 음성(p < 0.001)과 통계적으로 유의한 관련이 있었다. 또한, 불규칙한 종괴의 모양(p = 0.015)과 Type 3 조영증강 패턴(p = 0.002)은 임파선 전이와 통계적으로 유의한 관련이 있었다. 결론: 35세 이하의 젊은 여성에서 생긴 유방암의 자기공명영상 소견은 일반적인 유방암의 소견과 다르지 않지만, 자기공명영상에서 종괴의 테두리 조영증강, 불규칙한 종괴 모양 그리고 Type 3 조영증강 패턴은 나쁜 예후의 병리학적 인자들과 관련이 있다.

Purpose: Breast cancer of young women shows poor prognosis, but the imaging findings has not been well known. We evaluated the MRI characteristics of young women. Materials and Methods: From January 2009 to December 2013, we included 91 patients under the age of 35 who were diagnosed histologically as breast cancer and underwent MRI. The relationship between the clinical and histopathological prognostic factors was obtained using electronic medical records and the retrospective analysis of MRI findings was statistically analyzed. Results: The most common imaging findings of breast mass were irregular shape (53.7%), irregular margin (53.7%), heterogeneous enhancement (53.8%), and type 3 kinetic curve pattern (57.1%). In the multivariate analysis, the rim enhancement was significantly related to the higher tissue grade (p = 0.001), estrogen receptor negative (p < 0.001), and progesterone receptor negative (p < 0.001). The irregular mass shape (p = 0.015) and type 3 kinetic curve (p = 0.002) were related to lymph node metastasis. Conclusion: MRI findings of breast cancer in young women (${\leq}35-years-old$) are not different from those of general breast cancer, but the rim enhancement, irregular mass shape and type 3 kinetic curve are related with pathologic factors of poor prognosis.

키워드

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피인용 문헌

  1. 유방조직등가 팬텀을 이용한 디지털유방촬영장치의 FFDM과 DBT의 선량과 영상품질에 대한 융합 연구 vol.10, pp.2, 2019, https://doi.org/10.15207/jkcs.2019.10.2.029