Allergy, Asthma & Respiratory Disease

  • 제6권5호
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  • Pages.274-276
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  • 2018
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  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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Polyethylene glycol에 의한 아나필락시스 1예

Anaphylaxis due to polyethylene glycol: A case report

  • 김태세 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 최동철 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 이병재 (성균관대학교 의과대학 삼성서울병원 내과)
  • Kim, Tae-Se (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, Dong-Chull (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Byung-Jae (Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 투고 : 2017.10.26
  • 심사 : 2017.12.15
  • 발행 : 2018.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Polyethylene glycol (PEG) is a major component of bowel preparation solution for colonoscopy. It has been recognized as a safe and effective osmotic laxative that is rarely immunogenic. We here report a case of anaphylaxis due to PEG. A 49-year-old female came to the outpatient clinic wanting to find the cause of skin rash, nausea and respiratory difficulty after ingesting bowel evacuant solution (Clicool). She had visited local Emergency Department at the time of event and was diagnosed with anaphylaxis. We performed skin tests with components of Clicool to identify the cause of anaphylactic reactions. The result showed a positive skin response only to PEG. In contrast, skin test done in the control showed no reactions to PEG. This is the first case that revealed PEG to be an exact cause of anaphylaxis after ingesting a bowel evacuant.

키워드

과제정보

연구 과제 주관 기관 : Korea Institute of Drug Safety & Risk Management

참고문헌

  1. Schuman E, Balsam PE. Probable anaphylactic reaction to polyethylene glycol electrolyte lavage solution. Gastrointest Endosc 1991;37:411.
  2. Lee SH, Cha JM, Lee JI, Joo KR, Shin HP, Baek IH, et al. Anaphylactic shock caused by ingestion of polyethylene glycol. Intest Res 2015;13:90-4. https://doi.org/10.5217/ir.2015.13.1.90
  3. DiPiro JT, Michael KA, Clark BA, Dickson P, Vallner JJ, Bowden TA Jr, et al. Absorption of polyethylene glycol after administration of a PEG-electrolyte lavage solution. Clin Pharm 1986;5:153-5.
  4. Lee JS, Chae HS, Chung WC, Kim SS, Song HJ, Lee KM, et al. Urticaria reaction by oral polyethylene glycol ingestion. Korean J Gastrointest Endosc 2002;24:299-301.
  5. Lee SH, Hwang SH, Park JS, Park HS, Shin YS. Anaphylaxis to polyethylene glycol ($Colyte^{(R)}$) in a patient with diverticulitis. J Korean Med Sci 2016; 31:1662-3. https://doi.org/10.3346/jkms.2016.31.10.1662
  6. Wenande E, Garvey LH. Immediate-type hypersensitivity to polyethylene glycols: a review. Clin Exp Allergy 2016;46:907-22. https://doi.org/10.1111/cea.12760

피인용 문헌

  1. Coronavirus disease 2019 vaccines and relevant adverse reactions vol.9, pp.3, 2018, https://doi.org/10.4168/aard.2021.9.3.124