Annals of Pediatric Endocrinology and Metabolism

  • 제23권4호
  • /
  • Pages.215-219
  • /
  • 2018
  • /
  • 2287-1012(pISSN)
  • /
  • 2287-1292(eISSN)
대한소아내분비학회 (Korean Society of Pediatric Endocrinology)
권호 표지
DOI QR코드

DOI QR Code

The effect of overweight on the luteinizing hormone level after gonadorelin stimulation test in girls with idiopathic central precocious puberty

  • Lee, Hyun Young (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Yoon-Ji (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Ahn, Moon-Bae (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cho, Won-Kyoung (Department of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Suh, Byung-Kyu (Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 투고 : 2018.07.18
  • 심사 : 2018.10.11
  • 발행 : 2018.12.30
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: We investigated the effect of overweight on luteinizing hormone (LH) levels after a gonadorelin stimulation test in Korean girls with idiopathic central precocious puberty (CPP). Methods: Medical records of 234 girls diagnosed with idiopathic CPP were reviewed retrospectively. CPP was diagnosed when the peak LH levels after gonadorelin stimulation was >5.0 U/L. The enrolled girls had a peak LH level >5.0 U/L after a gonadorelin stimulation test. Selected girls were classified as normoweight (body mass index [BMI] below the 85th percentile with respect to age) and overweight (BMI greater than the 85th percentile with respect to age). Results: The peak LH ($8.95{\pm}2.85U/L$ vs. $11.97{\pm}8.42U/L$, P<0.01) and peak folliclestimulating hormone ($9.60{\pm}2.91U/L$ vs. $11.17{\pm}7.77U/L$, P=0.04) after gonadorelin stimulation were lower in overweight girls with idiopathic CPP than in normoweight girls with idiopathic CPP. Being overweight was negatively associated with peak LH levels after gonadorelin stimulation test (odds ratio, 0.89; 95 % confidence interval, 0.81-0.98, P=0.02). Conclusion: In girls with idiopathic CPP, being overweight led to a lower LH peak after gonadorelin stimulation. Further research is needed to better understand the role of overweight on gonadotropin secretion in precocious puberty.

키워드

참고문헌

  1. Carel JC, Leger J. Clinical practice. Precocious puberty. N Engl J Med 2008;358:2366-77. https://doi.org/10.1056/NEJMcp0800459
  2. Lee HS, Yoon JS, Hwang JS. Luteinizing hormone secretion during gonadotropin-releasing hormone stimulation tests in obese girls with central precocious puberty. J Clin Res Pediatr Endocrinol 2016;8:392-8. https://doi.org/10.4274/jcrpe.3091
  3. Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006;1:11-25. https://doi.org/10.1080/17477160600586747
  4. Burt Solorzano CM, McCartney CR. Obesity and the pubertal transition in girls and boys. Reproduction 2010;140:399-410. https://doi.org/10.1530/REP-10-0119
  5. Barber TM, McCarthy MI, Wass JA, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol (Oxf ) 2006;65:137-45. https://doi.org/10.1111/j.1365-2265.2006.02587.x
  6. Poretsky L. Commentary: Polycystic ovary syndrome--increased or preserved ovarian sensitivity to insulin? J Clin Endocrinol Metab 2006;91:2859-60. https://doi.org/10.1210/jc.2006-0317
  7. Moon JS, Lee SY, Nam CM, Choi JM, Choe BK, Seo JW, et al. 2007 Korean National Growth Charts: review of developmental process and an outlook. Korean J Pediatr 2008;51:1-25. https://doi.org/10.3345/kjp.2008.51.1.1
  8. Greulich WW, Pyle SD. Radiologic atlas of skeletal development of the hand and wrist. 2nd ed. Standford (CA): Standford University, 1959.
  9. Suh J, Choi MH, Kwon AR, Kim YJ, Jeong JW, Ahn JM, et al. Factors that predict a positive response on gonadotropinreleasing hormone stimulation test for diagnosing central precocious puberty in girls. Ann Pediatr Endocrinol Metab 2013;18:202-7. https://doi.org/10.6065/apem.2013.18.4.202
  10. Pagan YL, Srouji SS, Jimenez Y, Emerson A, Gill S, Hall JE. Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions. J Clin Endocrinol Metab 2006;91:1309-16. https://doi.org/10.1210/jc.2005-2099
  11. Roth LW, Bradshaw-Pierce EL, Allshouse AA, Lesh J, Chosich J, Bradford AP, et al. Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab 2014;99:E871-5. https://doi.org/10.1210/jc.2013-3598
  12. Sliwowska JH, Fergani C, Gawalek M, Skowronska B, Fichna P, Lehman MN. Insulin: its role in the central control of reproduction. Physiol Behav 2014;133:197-206. https://doi.org/10.1016/j.physbeh.2014.05.021
  13. Kavanagh K, Espeland MA, Sutton-Tyrrell K, Barinas- Mitchell E, El Khoudary SR, Wildman RP. Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN). Obesity (Silver Spring) 2013;21:1031-8. https://doi.org/10.1002/oby.20077
  14. Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A, Wilkin T. Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58). J Clin Endocrinol Metab 2014;99:3224-32. https://doi.org/10.1210/jc.2013-3902
  15. Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril 2008;90:346-51. https://doi.org/10.1016/j.fertnstert.2007.06.046
  16. Pilia S, Casini MR, Foschini ML, Minerba L, Musiu MC, Marras V, et al. The effect of puberty on insulin resistance in obese children. J Endocrinol Invest 2009;32:401-5. https://doi.org/10.1007/BF03346475
  17. Baratta M. Leptin--from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit 2002;8:RA282-92.
  18. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-70. https://doi.org/10.1038/27376
  19. Soliman AT, Yasin M, Kassem A. Leptin in pediatrics: a hormone from adipocyte that wheels several functions in children. Indian J Endocrinol Metab 2012;16(Suppl 3):S577-87. https://doi.org/10.4103/2230-8210.105575
  20. Pan H, Guo J, Su Z. Advances in understanding the interrelations between leptin resistance and obesity. Physiol Behav 2014;130:157-69. https://doi.org/10.1016/j.physbeh.2014.04.003

피인용 문헌

  1. MiR-664-2 impacts pubertal development in a precocious-puberty rat model through targeting the NMDA receptor-1† vol.100, pp.6, 2018, https://doi.org/10.1093/biolre/ioz044
  2. An Approach to the Evaluation and Management of the Obese Child With Early Puberty vol.6, pp.1, 2018, https://doi.org/10.1210/jendso/bvab173