Textile Science and Engineering (한국섬유공학회지)

The Korean Fiber Society (한국섬유공학회)
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Combination Drug Release of a Nanofiber Membrane Fabricated by Coaxial Dual Electrospinning

동축 이중 전기방사에 의해 성형한 나노섬유막의 복합약물 방출

  • Kim, Min Soo (Department of Biomaterial Science, Pusan National University) ;
  • Kim, Hong Sung (Department of Biomaterial Science, Pusan National University)
  • 김민수 (부산대학교 바이오소재과학과) ;
  • 김홍성 (부산대학교 바이오소재과학과)
  • Received : 2018.08.31
  • Accepted : 2018.10.01
  • Published : 2018.10.31
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Abstract

Coaxial dual electrospun nanofibers were designed for the sustained release of combination drugs. The nanofibers had a sheath-core structure composed of poly(ethylene oxide)/poly(D,L-lactic acid) blend in the sheath and poly(D,L-lactic acid) with drugs in the core. The properties as a carrier in a drug delivery system were analyzed using Fourier transform infrared spectrophotometry, X-ray diffractometry, scanning electron microscopy, and field emission transmission electron microscopy. The release behaviors of the combination drug of methotrexate/probucol were tested. Cumulative release amounts were proportionally increased according to the increased poly(ethylene oxide) ratio in the sheath. The initial release of probucol was approximately half that of methotrexate. In long-term release, the release rate of methotrexate decreased relatively, but that of probucol remained steady. The drug-diffusion milieu in the sheath of the coaxial nanofiber greatly affected the short- and long-term release of the drugs. The possibility of classified release control by components in combination drugs was ascertained.

Keywords

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