DOI QR코드

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경막외 진통은 비경막외 진통에 비해 초산부의 분만을 지연시키는가?: 후향성 관찰 연구

Does epidural analgesia delay the vaginal delivery of nulliparous women compared with non-epidural analgesia?: Retrospective observational study

  • 장소영 (제주대학교 의학전문대학원) ;
  • 이애령 (제주대학교 의학전문대학원 마취통증의학교실) ;
  • 윤소희 (제주대학교 의학전문대학원 마취통증의학교실) ;
  • 최윤숙 (제주대학교 의학전문대학원 마취통증의학교실) ;
  • 박종국 (제주대학교 의학전문대학원 마취통증의학교실) ;
  • 조우진 (제주대학교병원 마취통증의학과)
  • Jang, So Young (Medical course, Jeju National University School of Medicine) ;
  • Lee, Ae Ryoung (Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine) ;
  • Yun, So-hui (Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine) ;
  • Choi, Yun Suk (Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine) ;
  • Park, Jong Cook (Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine) ;
  • Cho, Woo Jin (Department of Anesthesiology and Pain Medicine, Jeju National University Hospital)
  • 투고 : 2018.11.12
  • 심사 : 2018.12.13
  • 발행 : 2018.12.31

초록

We conduct this study to compare the difference in duration of labor in nulliparous women received epidural analgesia or non-epidural analgesia for labor pain. This retrospective, observational study based on the review of the medical records from February 2014 to July 2017. Epidural analgesia was initiated with a 10 mL epidural bolus of 1% lidocaine and was maintained with a 0.1% mixture of ropivacaine with fentanyl. Non-epidural analgesia was initiated with pethidine 12.5 mg bolus, followed by additional boluses as needed. The primary outcome was the duration of the labor. 149 healthy nulliparous women at term pregnancies with no evidence of fetal distress were enrolled in this study. 92 women received non-epidural analgesia (Group NE) and 57 women received epidural analgesia (Group E). There were no significant differences between the two groups in maternal demographic characteristics. Using a Kaplan-Meier survival analysis, there was no significant difference in the overall duration of the labor(P=0.233). The duration of the first stage of labor was $187.6{\pm}167.3min$ in Group NE, $248.6{\pm}168.7min$ in Group E (Mean${\pm}$SD, P=0.032). The duration of the second stage of labor was $67.1{\pm}57.8min$ in Group NE, $64.1{\pm}47.5min$ in Group E (Mean${\pm}$SD, P=0.693). Epidural analgesia delayed the first stage of labor in this study. But there were no significant differences between the two groups in the duration of the second stage and the total duration of labor.

키워드

참고문헌

  1. Melzack R. The myth of painless childbirth (the John J. Bonica lecture). Pain 1984;19:321-37. https://doi.org/10.1016/0304-3959(84)90079-4
  2. Shnider SM, Abboud TK, Artal R, Henriksen EH, Stefani SJ, Levinson G. Maternal catecholamines decrease during labor after lumbar epidural anesthesia. Am J Obstet Gynecol 1983;147:13-5. https://doi.org/10.1016/0002-9378(83)90076-5
  3. Moya F, Morishima HO, Shnider SM, James LS. Influence of Maternal Hyperventilation on the Newborn Infant. Am J Obstet Gynecol 1965;91:76-84. https://doi.org/10.1016/0002-9378(65)90589-2
  4. Goetzl LM, Bulletins-Obstetrics ACoP. ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician-Gynecologists Number 36, July 2002. Obstetric analgesia and anesthesia. Obstet Gynecol 2002;100:177-91.
  5. Stubbs TM. Oxytocin for labor induction. Clin Obstet Gynecol 2000;43:489-94. https://doi.org/10.1097/00003081-200009000-00009
  6. Thorp JA, Hu DH, Albin RM, McNitt J, Meyer BA, Cohen GR, et al. The effect of intrapartum epidural analgesia on nulliparous labor: a randomized, controlled, prospective trial. Am J Obstet Gynecol 1993;169:851-8. https://doi.org/10.1016/0002-9378(93)90015-B
  7. Nageotte MP, Larson D, Rumney PJ, Sidhu M, Hollenbach K. Epidural analgesia compared with combined spinal-epidural analgesia during labor in nulliparous women. N Engl J Med 1997;337:1715-9. https://doi.org/10.1056/NEJM199712113372402
  8. Wong CA, Scavone BM, Peaceman AM, McCarthy RJ, Sullivan JT, Diaz NT, et al. The risk of cesarean delivery with neuraxial analgesia given early versus late in labor. N Engl J Med 2005;352:655-65. https://doi.org/10.1056/NEJMoa042573
  9. Chestnut DH, McGrath JM, Vincent RD Jr, Penning DH, Choi WW, Bates JN, et al. Does early administration of epidural analgesia affect obstetric outcome in nulliparous women who are in spontaneous labor? Anesthesiology 1994;80:1201-8. https://doi.org/10.1097/00000542-199406000-00006
  10. Ohel G, Gonen R, Vaida S, Barak S, Gaitini L. Early versus late initiation of epidural analgesia in labor: does it increase the risk of cesarean section? A randomized trial. Am J Obstet Gynecol 2006;194:600-5. https://doi.org/10.1016/j.ajog.2005.10.821
  11. Sultan P, Murphy C, Halpern S, Carvalho B. The effect of low concentrations versus high concentrations of local anesthetics for labour analgesia on obstetric and anesthetic outcomes: a meta-analysis. Can J Anaesth 2013;60:840-54. https://doi.org/10.1007/s12630-013-9981-z
  12. Costa-Martins JM, Dias CC, Pereira M, Tavares J. Effects of local anesthetic on the time between analgesic boluses and the duration of labor in patient-controlled epidural analgesia: prospective study of two ultra-low dose regimens of ropivacaine and sufentanil. Acta Med Port 2015;28:70-6. https://doi.org/10.20344/amp.5708
  13. Wang X, Xu S, Qin X, Li X, Feng SW, Liu Y, et al. Comparison Between the Use of Ropivacaine Alone and Ropivacaine With Sufentanil in Epidural Labor Analgesia. Medicine (Baltimore) 2015;94:e1882. https://doi.org/10.1097/MD.0000000000001882
  14. Tsen MDLawrence C, Thue MDB, Datta MDS, Segal MDS. Is Combined Spinal-Epidural Analgesia Associated with More Rapid Cervical Dilation in Nulliparous Patients When Compared with Conventional Epidural Analgesia?. Anesthesiology 1999;91:920-5. https://doi.org/10.1097/00000542-199910000-00010
  15. Wang TT, Sun S, Huang SQ. Effects of Epidural Labor Analgesia With Low Concentrations of Local Anesthetics on Obstetric Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Anesth Analg 2017;124:1571-80. https://doi.org/10.1213/ANE.0000000000001709
  16. Kariniemi V, Rosti J. Intramuscular pethidine (meperidine) during labor associated with metabolic acidosis in the newborn. J Perinat Med 1986;14:131-5. https://doi.org/10.1515/jpme.1986.14.2.131