Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Effect of Stress and Serotonin-Transporter-Linked Polymorphic Region Variants on Internet Gaming Disorder in Korean Adults

한국 성인남녀에서 스트레스와 세로토닌 전달체(5-HTTLPR) 유전자 변이가 인터넷 게임장애(IGD)에 미치는 영향

  • Hong, Hyung-Sook (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Jeong, Jo-Eun (Department of Psychiatry, College of Medicine, The Catholic University of Korea) ;
  • Cho, Hyun (Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea) ;
  • Kwak, Su-Min (Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea) ;
  • Choi, Mi Ran (Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea) ;
  • Choi, Jung-Seok (Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine) ;
  • Choi, Sam-Wook (Truemind Mental Health Clinic) ;
  • Kim, Dai-Jin (Department of Psychiatry, College of Medicine, The Catholic University of Korea)
  • 홍형숙 (가톨릭대학교 의과대학 정신과학교실) ;
  • 정조은 (가톨릭대학교 의과대학 정신과학교실) ;
  • 조현 (가톨릭대학교 의과대학 정신건강의학과 중독연구실) ;
  • 곽수민 (가톨릭대학교 의과대학 정신건강의학과 중독연구실) ;
  • 최미란 (가톨릭대학교 의과대학 정신건강의학과 중독연구실) ;
  • 최정석 (서울대학교 의과대학 정신과학교실) ;
  • 최삼욱 (진심정신건강의학과) ;
  • 김대진 (가톨릭대학교 의과대학 정신과학교실)
  • Received : 2018.04.20
  • Accepted : 2018.08.02
  • Published : 2018.08.31
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Abstract

Objectives Internet gaming disorder (IGD) is known to be related to stress and the serotonin-transporter-linked polymorphic region (5-HTTLPR) that is known to be associated with stress and has been studied to affect various psychiatric illness outbreaks. We tried to examine the relationship between stress, 5-HTTLPR and IGD. Methods A total of 59 participants with IGD, diagnosed according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria and 67 normal controls (NC) were enrolled. The IGD group and the NC were compared using chisquare test and independent sample t-test, and logistic regression analysis was used to examine the relationship between stress, the 5-HTTLPR, and IGD. Results The mean scores for anxiety, impulsivity and stress were significantly higher in the IGD group than in the NC. In addition, there was a significant association between stress and IGD [odds ratio (OR) = 1.172, 95% confidence interval (CI) = 1.008-1.362]. Conclusions This study showed that stress would affect IGD. Therefore, the evaluation and management of stress should be included in the diagnosis and treatment of IGD.

Keywords

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