DOI QR코드

DOI QR Code

Long-Term Effects of Adenotonsillectomy on Growth and Symptoms in Childhood

소아 성장 및 편도 비대 증상에 미치는 편도절제술의 장기 효과

  • Park, Woo Sung (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Ji, Yong Bae (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Lee, Seung Hwan (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Jeong, Jin Hyeok (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Song, Chang Myeon (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Tae, Kyung (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
  • 박우성 (한양대학교 의과대학 이비인후과학교실) ;
  • 지용배 (한양대학교 의과대학 이비인후과학교실) ;
  • 이승환 (한양대학교 의과대학 이비인후과학교실) ;
  • 정진혁 (한양대학교 의과대학 이비인후과학교실) ;
  • 송창면 (한양대학교 의과대학 이비인후과학교실) ;
  • 태경 (한양대학교 의과대학 이비인후과학교실)
  • Received : 2018.03.27
  • Accepted : 2018.07.04
  • Published : 2018.12.25

Abstract

Background and Objectives This study was performed to evaluate the long-term effect of adenotonsillectomy on childhood growth by examining preoperative growth status and presenting symptoms. Subjects and Method One hundred and four patients who underwent adenotonsillectomy from January to December 2009 were enrolled in this study. Clinical data were collected from medical record reviews and through the administered questionnaire. We investigated symptoms and growth changes during 5 years following the surgery. Results The mean age of patients was $6.0{\pm}1.94$ years (range, 3-10), with the male to female ratio of 62:42. Pre-operative symptoms were significantly improved after the surgery. The mean pre-operative height and weight percentiles were $53.6{\pm}27.4$ and $59.6{\pm}29.2$ at initial evaluation, and $67.1{\pm}26.4$ and $59.6{\pm}28.6$ at 5 years post adenotonsillectomy (p<0.001, p=0.989), respectively. An increase in height percentile was more prominent in patients whose pre-operative height percentile was less than 50 compared to those with a percentile of 50 or more (p<0.001). Weight percentile was significantly increased in those with the pre-operative weight percentile of less than 50 and decreased in patients with a percentile of 50 or more. Conclusion Adenotonsillectomy has a positive effect on height growth in children with adenotonsillar hypertrophy, especially in patients whose height percentile is less than 50. Weight gain also can be expected in preoperative low-weight children.

Keywords

References

  1. Brandtzaeg P. Immunology of tonsils and adenoids: everything the ENT surgeon needs to know. Int J Pediatr Otorhinolaryngol 2003;67 Suppl 1:S69-76. https://doi.org/10.1016/j.ijporl.2003.08.018
  2. Siegel G. Biochemical characterization of the proliferation pool of lymphatic cells in the human tonsil and demonstration of the agedependent pool size reduction. Acta Otolaryngol 1979;87(5-6):560-6. https://doi.org/10.3109/00016487909126465
  3. Greene MG, Carroll JL. Consequences of sleep-disordered breathing in childhood. Curr Opin Pulm Med 1997;3(6):456-63. https://doi.org/10.1097/00063198-199711000-00013
  4. Liu J, Liu X, Ji X, Wang Y, Zhou G, Chen X. Sleep disordered breathing symptoms and daytime sleepiness are associated with emotional problems and poor school performance in children. Psychiatry Res 2016;242:218-25. https://doi.org/10.1016/j.psychres.2016.05.017
  5. Marcus CL. Sleep-disordered breathing in children. Am J Respir Crit Care Med 2001;164(1):16-30. https://doi.org/10.1164/ajrccm.164.1.2008171
  6. Bar A, Tarasiuk A, Segev Y, Phillip M, Tal A. The effect of adenotonsillectomy on serum insulin-like growth factor-I and growth in children with obstructive sleep apnea syndrome. J Pediatr 1999; 135(1):76-80. https://doi.org/10.1016/S0022-3476(99)70331-8
  7. Stradling JR, Thomas G, Warley AR, Williams P, Freeland A. Effect of adenotonsillectomy on nocturnal hypoxaemia, sleep disturbance, and symptoms in snoring children. Lancet 1990;335(8684):249-53. https://doi.org/10.1016/0140-6736(90)90068-G
  8. Yilmaz MD, Hosal AS, Oguz H, Yordam N, Kaya S. The effects of tonsillectomy and adenoidectomy on serum IGF-I and IGFBP3 levels in children. Laryngoscope 2002;112(5):922-5. https://doi.org/10.1097/00005537-200205000-00026
  9. Bitar MA, Dowli A, Mourad M. The effect of tonsillectomy on the immune system: a systematic review and meta-analysis. Int J Pediatr Otorhinolaryngol 2015;79(8):1184-91. https://doi.org/10.1016/j.ijporl.2015.05.016
  10. Fernandes AA, Alcantara TA, D'Avila DV, D'Avila JS. Study of weight and height development in children after adenotonsillectomy. Braz J Otorhinolaryngol 2008;74(3):391-4. https://doi.org/10.1016/S1808-8694(15)30573-5
  11. Katz ES, Moore RH, Rosen CL, Mitchell RB, Amin R, Arens R, et al. Growth after adenotonsillectomy for obstructive sleep apnea: an RCT. Pediatrics 2014;134(2):282-9. https://doi.org/10.1542/peds.2014-0591
  12. Selimoglu E, Selimoglu MA, Orbak Z. Does adenotonsillectomy improve growth in children with obstructive adenotonsillar hypertrophy? J Int Med Res 2003;31(2):84-7. https://doi.org/10.1177/147323000303100204
  13. Smith DF, Vikani AR, Benke JR, Boss EF, Ishman SL. Weight gain after adenotonsillectomy is more common in young children. Otolaryngol Head Neck Surg 2013;148(3):488-93. https://doi.org/10.1177/0194599812473412
  14. Korea centers for disease control and prevention. Child growth charts. [online] 2007 Oct [cited 2017 Jun 27]. Available from: http://www.cdc.go.kr/CDC/info/CdcKrInfo0201.jsp?menuIds=HOME001-MNU1154-MNU0005-MNU1889&cid=1235.
  15. Leiberman A, Stiller-Timor L, Tarasiuk A, Tal A. The effect of adenotonsillectomy on children suffering from obstructive sleep apnea syndrome (OSAS): the Negev perspective. Int J Pediatr Otorhinolaryngol 2006;70(10):1675-82. https://doi.org/10.1016/j.ijporl.2006.06.002
  16. Randel A. AAO-HNS guidelines for tonsillectomy in children and adolescents. Am Fam Physician 2011;84(5):566-73.
  17. Clayburgh D, Milczuk H, Gorsek S, Sinden N, Bowman K, MacArthur C. Efficacy of tonsillectomy for pediatric patients with Dysphagia and tonsillar hypertrophy. Arch Otolaryngol Head Neck Surg 2011;137(12):1197-202. https://doi.org/10.1001/archoto.2011.196
  18. Conley SF, Beecher RB, Delaney AL, Norins NA, Simpson PM, Li SH. Outcomes of tonsillectomy in neurologically impaired children. Laryngoscope 2009;119(11):2231-41. https://doi.org/10.1002/lary.20600
  19. Costa DJ, Mitchell R. Adenotonsillectomy for obstructive sleep apnea in obese children: a meta-analysis. Otolaryngol Head Neck Surg 2009;140(4):455-60. https://doi.org/10.1016/j.otohns.2008.12.038
  20. Farmarzi M, Shishegar M, Heydari ST, Haghighi A, Sharouny H. Effects of adenotonsillectomy on serum levels of IGF-1 and IGFBP-3 and growth indices in children with adenotonsillar hypertrophy or recurrent tonsillitis. Iran J Otorhinolaryngol 2016;28(88):329-35.
  21. Kiris M, Muderris T, Celebi S, Cankaya H, Bercin S. Changes in serum IGF-1 and IGFBP-3 levels and growth in children following adenoidectomy, tonsillectomy or adenotonsillectomy. Int J Pediatr Otorhinolaryngol 2010;74(5):528-31. https://doi.org/10.1016/j.ijporl.2010.02.014
  22. Gozal D, Serpero LD, Kheirandish-Gozal L, Capdevila OS, Khalyfa A, Tauman R. Sleep measures and morning plasma TNF-alpha levels in children with sleep-disordered breathing. Sleep 2010;33(3):319-25. https://doi.org/10.1093/sleep/33.3.319
  23. Yang N, Ji Y, Liu Y. Effect of transoral endoscopic adenoidectomy on peripheral blood T-lymphocyte subsets in children with obstructive sleep apnea-hypopnea syndrome and its treatment strategy. Exp Ther Med 2017;14(4):3022-8. https://doi.org/10.3892/etm.2017.4851

Cited by

  1. The Efficacy of Nasal Surgery on Pharyngeal Airway vol.63, pp.1, 2018, https://doi.org/10.3342/kjorl-hns.2019.00101