Biomedical Engineering Letters

  • 제8권4호
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  • Pages.393-398
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  • 2018
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  • 2093-9868(pISSN)
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  • 2093-985X(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane

  • Farzamfar, Saeed (Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences) ;
  • Salehi, Majid (Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences) ;
  • Ehterami, Arian (Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences) ;
  • Naseri-Nosar, Mahdi (Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences) ;
  • Vaez, Ahmad (Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences) ;
  • Zarnani, Amir Hassan (Department of Immunology, School of Public Health, Tehran University of Medical Sciences) ;
  • Sahrapeyma, Hamed (Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University) ;
  • Shokri, Mohammad-Reza (Department of Immunology, School of Medicine, Iran University of Medical Sciences) ;
  • Aleahmad, Mehdi (Department of Immunology, School of Public Health, Tehran University of Medical Sciences)
  • 투고 : 2018.06.05
  • 심사 : 2018.09.04
  • 발행 : 2018.11.30
⟨ 이전 논문 다음 논문 ⟩

초록

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of $3{\times}10^4cells/cm^2$ and implanted onto a rat's $1.50{\times}1.50cm^2$ full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.

키워드

참고문헌

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