대한정형외과학회지 (Journal of the Korean Orthopaedic Association)

  • 제53권6호
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  • Pages.540-546
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  • 2018
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  • 1226-2102(pISSN)
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  • 2005-8918(eISSN)
대한정형외과학회 (Korean Orthopaedic Association)
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수근관절 활액막염 원인 질환 진단을 위한 다중적 접근법

Multimodal Diagnostic Approach for Synovitis of the Wrist

  • 배기정 (서울대학교 의과대학 정형외과학교실) ;
  • 김지형 (서울대학교 의과대학 정형외과학교실) ;
  • 윤찬 (서울대학교 의과대학 정형외과학교실) ;
  • 홍성화 (서울대학교 의과대학 정형외과학교실) ;
  • 공현식 (서울대학교 의과대학 정형외과학교실) ;
  • 백구현 (서울대학교 의과대학 정형외과학교실)
  • Bae, Kee Jeong (Department of Orthopedic Surgery, Seoul National University College of Medicine) ;
  • Kim, Jihyeung (Department of Orthopedic Surgery, Seoul National University College of Medicine) ;
  • Yoon, Chan (Department of Orthopedic Surgery, Seoul National University College of Medicine) ;
  • Hong, Seong Hwa (Department of Orthopedic Surgery, Seoul National University College of Medicine) ;
  • Gong, Hyun Sik (Department of Orthopedic Surgery, Seoul National University College of Medicine) ;
  • Baek, Goo Hyun (Department of Orthopedic Surgery, Seoul National University College of Medicine)
  • 투고 : 2017.11.14
  • 심사 : 2018.02.20
  • 발행 : 2018.12.30
⟨ 이전 논문 다음 논문 ⟩

초록

목적: 본 연구의 목적은 수근관절 활액막염 진단하에 활막 절제술을 시행한 환자들을 대상으로 원인 질환 진단을 위한 다중적 접근법을 제시하고자 한다. 대상 및 방법: 2000년 1월부터 2013년 12월까지 서울대학교병원에서 수근관절 활액막염 진단하에 활막 절제술을 시행한 환자 중 수술 전 수근관절 조영 증강 자기공명영상 검사를 시행한 29명의 환자를 대상으로 후향적으로 분석하였다. 이 중 17명의 환자는 수술 전 $Tc^{99m}$ 백혈구 스캔 검사를 시행하였다. 류마티스 관절염 진단 기준에 부합하는 환자의 경우, 수근관절 자기공명영상 및 조직 병리 검사 결과 중 하나 이상에서 류마티스 관절염을 시사하는 소견이 나왔다면 류마티스 관절염으로 최종 진단하였다. 만약 자기공명영상 검사와 조직 검사 소견이 시사하는 진단이 다르게 나타나는 경우에는 조직 검사 소견 결과를 토대로 확진하였다. 결과: 류마티스 관절염 진단 기준을 충족하는 9명의 환자 중 7명의 환자는 류마티스 관절염으로 최종 확진되었으며, 2명의 환자는 결핵성 관절염으로 최종 진단되었다. 류마티스 관절염 진단 기준을 충족시키지 못한 20명의 환자 중 12명은 자기공명영상 검사 및 조직 검사 결과 모두 동일한 질환을 시사하는 것으로 나왔으며 나머지 8명의 환자들은 임상 양상, 자기공명영상 및 조직학적 소견에 근거하여 5명은 비특이적 만성 활액막염, 1명은 류마티스 관절염, 2명은 결핵성 관절염으로 최종 진단되었다. 결론: 자기공명영상 검사 및 백혈구 스캔 검사는 수근관절 활액막염 원인 질환 진단에 많은 도움이 되는 유용한 검사이다. 진단이 어렵거나 약물 치료에 반응이 없는 경우에 활막 절제술을 통한 조직 병리 검사 결과는 매우 유용할 수 있다.

Purpose: The purpose of this study was to suggest a multimodal diagnostic approach to determine the cause of the disease in patients diagnosed with synovitis of the wrist and who underwent synovectomy. Materials and Methods: Twenty-nine patients, who underwent contrast magnetic resonance imaging (MRI) preoperatively and synovectomy from January 2000 to December 2013, were reviewed retrospectively. Among them, 17 patients underwent a $Tc^{99m}$ white blood cell (WBC) scan preoperatively. In patients who met the diagnostic criteria of rheumatoid arthritis (RA), the diagnosis was confirmed as RA if the MRI finding or histology was compatible with RA. If the MRI finding and histology were disparate, the final diagnosis was made based on the histologic finding. Results: Of the nine patients who met the diagnostic criteria of RA, seven patients were finally diagnosed as RA and two patients as tuberculous arthritis. Of the 20 patients who did not meet the diagnostic criteria of RA, the MRI findings and histology were consistent with the same disease in 12 patients. In the remaining eight patients, five were diagnosed with nonspecific chronic synovitis, one with RA, and two with tuberculous arthritis based on the clinical findings, MRI, and histology findings. Conclusion: MRI and a WBC scan are very useful imaging modalities for diagnosing the causative condition of the wrist synovitis. A histology evaluation after synovectomy can also be useful in cases with a difficult diagnosis or are refractory to medications.

키워드

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