Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Fecal Microbiota Transplantation to Patients with Refractory Very Early Onset Ulcerative Colitis

  • Yodoshi, Toshifumi (Department of Pediatrics, Okinawa Chubu Hospital) ;
  • Hurt, Thomas L. (Department of Emergency Medicine, Mary Bridge Children's Hospital)
  • Received : 2018.02.05
  • Accepted : 2018.03.14
  • Published : 2018.10.15
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Abstract

Recently, fecal microbiota transplantation (FMT) has been attracting attention as a possible medical treatment of ulcerative colitis (UC). A randomized controlled trial of FMT for children with UC is currently underway. Therapeutic effects of FMT for adults with UC remain controversial. We report two cases of early-onset UC in children. A patient was diagnosed with UC at age 1-year 9-month and underwent FMT at age 2-year 3-month. He attained clinical remission for three weeks after FMT, but then relapsed at four weeks, ultimately undergoing a total colectomy. Another child was diagnosed with UC at 2-year 10-month and she underwent FMT at age 5 years. She has remained in clinical remission following FMT for 24 months and her UC has been maintained without complications with tacrolimus and azathioprine. We report that FMT for early-onset UC appears to be safe and potentially effective.

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References

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