DOI QR코드

DOI QR Code

A Newborn with Gastric Hemangioma Treated Using Propranolol

  • Kaya, Huseyin (Division of Neonatology, Department of Pediatrics, Turgut Ozal Medical Center, Inonu University School of Medicine) ;
  • Gokce, Ismail Kursad (Division of Neonatology, Department of Pediatrics, Turgut Ozal Medical Center, Inonu University School of Medicine) ;
  • Gungor, Sukru (Division of Pediatric Gastroenterology, Department of Pediatrics, Turgut Ozal Medical Center, Inonu University School of Medicine) ;
  • Turgut, Hatice (Division of Neonatology, Department of Pediatrics, Turgut Ozal Medical Center, Inonu University School of Medicine) ;
  • Ozdemir, Ramazan (Division of Neonatology, Department of Pediatrics, Turgut Ozal Medical Center, Inonu University School of Medicine)
  • Received : 2017.10.28
  • Accepted : 2017.12.29
  • Published : 2018.10.15

Abstract

Gastric hemangiomas are rare benign vascular tumors that can cause severe gastrointestinal system bleeding. We presented the case of a neonate with fresh bleeding and melena from the orogastric tube and detected gastric hemangioma in esophagogastroduodenoscopic examination. Propranolol is widely used in treatment of cutaneous hemangiomas and non-gastric gastrointestinal system hemangiomas. However, the surgical approach is preferred for treating gastric hemangiomas, and there are few reports of gastric hemangiomas associated with non-surgical treatment. Gastric hemorrhage decreased with antacid and somatostatin treatment. Propranolol treatment was initiated before the surgery decision. After three weeks of treatment, we observed regression in the hemangioma with endoscopic evaluation. During the course of treatment, the patient's gastrointestinal system bleeding did not recur, and there were no side effects associated with propranolol.

Keywords

References

  1. Parolini F, Colusso M, Giannotti G, Cheli M, Alberti D. Gastric hemangiomas in children. Int J Gastroenterol Hepatol Transpl Nutr 2016;1:10-4. https://doi.org/10.21037/tgh.2016.01.05
  2. Hansen LF, Wewer V, Pedersen SA, Matzen P, Paerregaard A. Severe blue rubber bleb nevus syndrome in a neonate. Eur J Pediatr Surg 2009;19:47-9. https://doi.org/10.1055/s-2008-1038367
  3. Akcam M, Pirgon O, Salman H, Kockar C. Multiple gastrointestinal hemangiomatosis successfully treated with propranolol. J Pediatr Gastroenterol Nutr 2015;60:e16. https://doi.org/10.1097/MPG.0b013e31829530af
  4. Lee YA, Chun P, Hwang EH, Lee YJ, Kim CW, Park JH. Gastric hemangioma treated with argon plasma coagulation in a newborn infant. Pediatr Gastroenterol Hepatol Nutr 2017;20:134-7. https://doi.org/10.5223/pghn.2017.20.2.134
  5. Holden KR, Alexander F. Diffuse neonatal hemangiomatosis. Pediatrics 1970;46:411-21.
  6. Han EC, Kim SH, Kim HY, Jung SE, Park KW. Gastrointestinal hemangioma in childhood: a rare cause of gastrointestinal bleeding. Korean J Pediatr 2014;57:245-9. https://doi.org/10.3345/kjp.2014.57.5.245
  7. Morris GA, Stratchko L, Sabri M. Intestinal hemangio- ma presenting as recurrent hematochezia in a 6-week- old male. J Pediatr Surg Case Rep 2015;3:280-2. https://doi.org/10.1016/j.epsc.2015.05.005
  8. Khan K, Weisdorf-Schindele S. Gastric hemangiomas in an infant managed with argon plasma coagulation. Pediatr Endosurgery Innov Tech 2003;7:185-8. https://doi.org/10.1089/109264103766757961
  9. Soukoulis IW, Liang MG, Fox VL, Mulliken JB, Alomari AI, Fishman SJ. Gastrointestinal infantile hemangioma: presentation and management. J Pediatr Gastroenterol Nutr 2015;61:415-20. https://doi.org/10.1097/MPG.0000000000000812
  10. Nagaya M, Kato J, Niimi N, Tanaka S, Akiyoshi K, Tanaka T. Isolated cavernous hemangioma of the stomach in a neonate. J Pediatr Surg 1998;33:653-4. https://doi.org/10.1016/S0022-3468(98)90338-4
  11. Magnano A, Privitera A, Calogero G, Nanfito' L, Basile G, Sanfilippo G. Solitary hemangioma of the small intestine: an unusual cause of bleeding diagnosed at capsule endoscopy. J Pediatr Surg 2005;40:e25-7.
  12. Greene AK, Kim S, Rogers GF, Fishman SJ, Olsen BR, Mulliken JB. Risk of vascular anomalies with Down syndrome. Pediatrics 2008;121:e135-40. https://doi.org/10.1542/peds.2007-1316
  13. Kavin H, Berman J, Martin TL, Feldman A, Forsey-Koukol K. Successful wireless capsule endoscopy for a 2.5-year-old child: obscure gastrointestinal bleeding from mixed, juvenile, capillary hemangioma-angiomatosis of the jejunum. Pediatrics 2006;117:539-43. https://doi.org/10.1542/peds.2005-0710
  14. Chen TS, Eichenfield LF, Friedlander SF. Infantile hemangiomas: an update on pathogenesis and therapy. Pediatrics 2013;131:99-108. https://doi.org/10.1542/peds.2012-1128
  15. Bertrand J, McCuaig C, Dubois J, Hatami A, Ondrejchak S, Powell J. Propranolol versus prednisone in the treatment of infantile hemangiomas: a retrospective comparative study. Pediatr Dermatol 2011;28: 649-54. https://doi.org/10.1111/j.1525-1470.2011.01551.x
  16. Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A. Blue rubber bleb nevus syndrome. Acta Paediatr 2010;99:632-5. https://doi.org/10.1111/j.1651-2227.2009.01608.x
  17. Desa LA, Bridger J, Grace PA, Krausz T, Spencer J. Primary jejunoileal tumors: a review of 45 cases. World J Surg 1991;15:81-6. https://doi.org/10.1007/BF01658970
  18. Léauté-labrèze C, Hoeger P, Mazereeuw-Hautier J, Guibaud L, Baselga E, Posiunas G, et al. A randomized, controlled trial of oral propranolol in infantile hemangioma. N Engl J Med 2015;372:735-46. https://doi.org/10.1056/NEJMoa1404710
  19. Horev A, Haim A, Zvulunov A. Propranolol induced hypoglycemia. Pediatr Endocrinol Rev 2015;12:308-10.
  20. de Graaf M, Breur JMPJ, Raphaël MF, Vos M, Breugem CC, Pasmans SGMA. Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. J Am Acad Dermatol 2011;65:320-7. https://doi.org/10.1016/j.jaad.2010.06.048

Cited by

  1. The pediatric stomach - congenital abnormalities vol.51, pp.13, 2018, https://doi.org/10.1007/s00247-021-05155-z