Journal of Industrial and Engineering Chemistry

  • Volume 67
  • /
  • Pages.365-372
  • /
  • 2018
  • /
  • 1226-086X(pISSN)
  • /
  • 1876-794X(eISSN)
The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Visible light-cured glycol chitosan hydrogel dressing containing endothelial growth factor and basic fibroblast growth factor accelerates wound healing in vivo

  • Yoo, Youngbum (Department of Surgery, School of Medicine, The Konkuk University) ;
  • Hyun, Hoon (Department of Biomedical Sciences, Chonnam National University Medical School) ;
  • Yoon, Sun-Jung (Department of Orthopedic Surgery, Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital) ;
  • Kim, So Yeon (Department of Dental Hygiene, College of Health Sciences, Cheongju University) ;
  • Lee, Deok-Won (Department of Oral & Maxillofacial Surgery, Kyung Hee University Dental Hospital at Gangdong, Kyung Hee University) ;
  • Um, Sewook (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Hong, Sung Ok (Department of Dentistry, Catholic Kwandong University, School of Medicine, International St. Mary's Hospital) ;
  • Yang, Dae Hyeok (Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea)
  • Received : 2018.06.12
  • Accepted : 2018.07.05
  • Published : 2018.11.25
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Abstract

Wounds that heal with excessive scar formation result in poor functional and aesthetic outcomes. To address this, in our study, visible light cured glycol chitosan (GCH) hydrogels containing endothelial growth factor (EGF) and basic fibroblast growth factor (bFGF) were prepared (GCH-EGF, GCH-FGF and GCH-EGF/FGF) and evaluated their efficacies on the improvement of wound healing in vivo. In vitro release test showed that the growth factors were released in a sustained manner along with initial burst for 24 h. In vitro cell proliferation assay of L-929 mouse fibroblast cell line resulted in the superior ability of GCH-EGF/FGF on the rate. In vivo results demonstrated that the growth factor loaded GCHs further enhanced wound healing compared with GCH. In particular, GCH-EGF/EFG showed the most remarkable wound healing effect among the samples.

Keywords

Acknowledgement

Supported by : Ministry of Trade, Industry, and Energy (MOTIE), National Research Foundation of Korea (NRF)

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