The Korean journal of helicobacter and upper gastrointestinal research (대한상부위장관⦁헬리코박터학회지)

Korean College of Helicobacter and upper Gastrointestinal Reseaarch (대한상부위장관ㆍ헬리코박터학회)
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Predictive Factors for Improvement of Atrophic Gastritis and Intestinal Metaplasia: A Long-term Prospective Clinical Study

위축성 위염과 장상피화생의 호전에 영향을 미치는 인자에 대한 전향적 연구

  • Hwang, Young-Jae (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Yun, Chang Yong (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Kwon, Min Gu (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Baek, Sung Min (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Kwon, Yeong Jae (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Hye Seung (Department of Pathology, Seoul National University Bundang Hospital) ;
  • Lee, Jae Bong (Division of Statistics in Medical Research Collaborating Center, Seoul National University Bundang Hospital) ;
  • Choi, Yoon Jin (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Yoon, Hyuk (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Shin, Cheol Min (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Park, Young Soo (Department of Internal Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Dong Ho (Department of Internal Medicine, Seoul National University Bundang Hospital)
  • 황영재 (분당서울대학교병원 내과) ;
  • 김나영 (분당서울대학교병원 내과) ;
  • 윤창용 (분당서울대학교병원 내과) ;
  • 권민구 (분당서울대학교병원 내과) ;
  • 백성민 (분당서울대학교병원 내과) ;
  • 권영재 (분당서울대학교병원 내과) ;
  • 이혜승 (분당서울대학교병원 병리과) ;
  • 이제봉 (분당서울대학교병원 의학연구협력센터 통계과) ;
  • 최윤진 (분당서울대학교병원 내과) ;
  • 윤혁 (분당서울대학교병원 내과) ;
  • 신철민 (분당서울대학교병원 내과) ;
  • 박영수 (분당서울대학교병원 내과) ;
  • 이동호 (분당서울대학교병원 내과)
  • Received : 2018.06.01
  • Accepted : 2018.07.22
  • Published : 2018.09.30
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Abstract

Background/Aims: To investigate the predictive factors for improvement of atrophic gastritis (AG) and intestinal metaplasia (IM). Materials and Methods: A total of 778 subjects were prospectively enrolled and followed up for 10 years. Histological analysis of AG and IM was performed by using the updated Sydney system. To find the predictive factors for reversibility of AG and IM, 24 factors including genetic polymorphisms and bacterial and environmental factors were analyzed. Results: In all subjects, the predictive factor by multivariate analysis for improvement of both antral and corpus AG was successful eradication. The predictive factors for improvement of antral IM were age and successful eradication. The predictive factor for improvement of corpus IM was successful eradication. In patients with Helicobacter pylori infection, age and cagA were predictive factors for improvement of AG and IM. In patients with H. pylori eradication, monthly income and cagA were predictive factors for improvement of AG and IM. Conclusions: H. pylori eradication is an important predictive factor of regression of AG and IM and would be beneficial for the prevention of intestinal-type gastric cancer. Young age, high income, and cagA are additional predictive factors for improving AG and IM status. Thus, various factors affect the improvement of AG and IM.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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