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Concurrence of Circumscribed Morphea and Segmental Vitiligo: A Case Report

  • Lee, Ji Su (Department of Dermatology, SMG-SNU Boramae Medical Center) ;
  • Park, Hyun-sun (Department of Dermatology, SMG-SNU Boramae Medical Center) ;
  • Cho, Soyun (Department of Dermatology, SMG-SNU Boramae Medical Center) ;
  • Yoon, Hyun-Sun (Department of Dermatology, SMG-SNU Boramae Medical Center)
  • Received : 2017.05.22
  • Accepted : 2017.12.14
  • Published : 2018.12.01

Abstract

Although a few reports have noted the concurrent presentation of morphea and vitiligo at distinctly separate sites in the same patient, it is extremely rare that these two conditions occur at the same sites in a patient. We report the case of a 10-year-old Korean girl with morphea and vitiligo and those lesions occurred at the same sites and progressed simultaneously. An autoimmunity and a cutaneous mosaicism was considered to be involved in such an unique presentation as the pathogenesis is concerned.

Keywords

References

  1. Bonifati C, Impara G, Morrone A, Pietrangeli A, Carducci M. Simultaneous occurrence of linear scleroderma and homolateral segmental vitiligo. J Eur Acad Dermatol Venereol 2006;20:63-65. https://doi.org/10.1111/j.1468-3083.2005.01336.x
  2. Yadav P, Garg T, Chander R, Nangia A. Segmental vitiligo with segmental morphea: an autoimmune link? Indian Dermatol Online J 2014;5(Suppl 1):23-25. https://doi.org/10.4103/2229-5178.144517
  3. Finkelstein E, Amichai B, Metzker A. Coexistence of vitiligo and morphea: a case report and review of the literature. J Dermatol 1995;22:351-353. https://doi.org/10.1111/j.1346-8138.1995.tb03402.x
  4. Saihan EM, Peachey RD. Vitiligo and morphoea. Clin Exp Dermatol 1979;4:103-106. https://doi.org/10.1111/j.1365-2230.1979.tb01597.x
  5. Yorulmaz A, Kilic S, Artuz F, Kahraman E. Concomitant appearance of morphea and vitiligo in a patient with autoimmune thyroiditis. Postepy Dermatol Alergol 2016;33:314-316.
  6. Dervis E, Acbay O, Barut G, Karaoglu A, Ersoy L. Association of vitiligo, morphea, and Hashimoto's thyroiditis. Int J Dermatol 2004;43:236-237. https://doi.org/10.1111/j.1365-4632.2004.01973.x
  7. Soylu S, Gul U, Gonul M, Kilic A, Cakmak SK, Demiriz M. An uncommon presentation of the co-existence of morphea and vitiligo in a patient with chronic hepatitis B virus infection: is there a possible association with autoimmunity? Am J Clin Dermatol 2009;10:336-338. https://doi.org/10.2165/11310800-000000000-00000
  8. Bonilla-Abadia F, Munoz-Buitron E, Ochoa CD, Carrascal E, Canas CA. A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis. Case report. BMC Res Notes 2012;5:689. https://doi.org/10.1186/1756-0500-5-689
  9. Soma Y, Fujimoto M. Frontoparietal scleroderma (en coup de sabre) following Blaschko's lines. J Am Acad Dermatol 1998;38:366-368. https://doi.org/10.1016/S0190-9622(98)70586-9
  10. Gonzalez-Lopez MA, Drake M, Gonzalez-Vela MC, Armesto S, Llaca HF, Val-Bernal JF. Generalized morphea and primary biliary cirrhosis coexisting in a male patient. J Dermatol 2006;33:709-713. https://doi.org/10.1111/j.1346-8138.2006.00165.x
  11. Parra V, Driban N, Bassotti A. Localized morphea and myasthenia gravis. J Am Acad Dermatol 2003;49:E12. https://doi.org/10.1016/S0190-9622(03)01121-6
  12. Neucks SH, Moore TL, Lichtenstein JR, Baldassare AR, Weiss TD, Zuckner J. Localized scleroderma and idiopathic thrombocytopenia. J Rheumatol 1980;7:741-744.
  13. Arif T, Hassan I, Nisa N. Morphea and vitiligo-A very uncommon association. Our Dermatol Online 2015;6:232-234. https://doi.org/10.7241/ourd.20152.62
  14. Takehara K, Sato S. Localized scleroderma is an autoimmune disorder. Rheumatology 2005;44:274-279. https://doi.org/10.1093/rheumatology/keh487
  15. Cunliffe WJ, Hall R, Newell DJ, Stevenson CJ. Vitiligo, thyroid disease and autoimmunity. Br J Dermatol 1968;80:135-139. https://doi.org/10.1111/j.1365-2133.1968.tb12282.x
  16. Dawber RP. Vitiligo in mature-onset diabetes mellitus. Br J Dermatol 1968;80:275-278. https://doi.org/10.1111/j.1365-2133.1968.tb12298.x
  17. Grunnet I, Howitz J, Reymann F, Schwartz M. Vitiligo and pernicious anemia. Arch Dermatol 1970;101:82-85. https://doi.org/10.1001/archderm.1970.04000010084015
  18. Bor S, Feiwel M, Chanarin I. Vitiligo and its aetiological relationship to organ-specific autoimmune disease. Br J Dermatol 1969;81:83-88. https://doi.org/10.1111/j.1365-2133.1969.tb15985.x
  19. Bowcock AM, Fernandez-Vina M. Targeting skin: vitiligo and autoimmunity. J Invest Dermatol 2012;132:13-15. https://doi.org/10.1038/jid.2011.353
  20. Czajkowski R, Mecinska-Jundzill K. Current aspects of vitiligo genetics. Postepy Dermatol Alergol 2014;31:247-255.

Cited by

  1. Autoimmunity in Segmental Vitiligo vol.11, pp.None, 2018, https://doi.org/10.3389/fimmu.2020.568447