Gut and Liver

  • 제12권6호
  • /
  • Pages.633-640
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  • 2018
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  • 1976-2283(pISSN)
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  • 2005-1212(eISSN)
대한간학회 (The Korean Association for the Study of the Liver)
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Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study

  • Bang, Ki Bae (Department of Internal Medicine, Dankook University College of Medicine) ;
  • Park, Jung Ho (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 투고 : 2018.03.22
  • 심사 : 2018.05.14
  • 발행 : 2018.11.15
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI reduction could resolve EE. Methods: A retrospective cohort study was performed to assess the natural course of EE according to changes in BMI. Participants undergoing health check-ups from 2006 to 2012 were enrolled, and 1,126 subjects with EE were included. The degree of esophagitis was measured by upper endoscopy and serially checked over a 5-year follow-up. Logistic regression and Cox proportional hazards models were used to investigate the association between BMI reduction and EE resolution. Results: Substantial weight loss is associated with EE resolution. The adjusted odds ratio for EE resolution was 1.44 (95% confidence interval [CI], 1.09 to 1.92) among participants with a decrease in BMI compared to those with no decrease in BMI. The EE resolution rate was related to the degree of BMI reduction. The effect of weight loss on EE resolution was higher among subjects who lost more weight. Compared with subjects with no decrease in BMI, the hazard ratios for EE resolution were 1.09 (95% CI, 0.89 to 1.35), 1.31 (95% CI, 1.01 to 1.72) and 2.12 (95% CI, 1.44 to 3.12) in subjects with BMI reductions of ${\leq}1$, 1-2, and >$2kg/m^2$, respectively. Conclusions: EE resolution is associated with a decrease in BMI, and weight loss is potentially an effective GERD treatment.

키워드

과제정보

연구 과제 주관 기관 : Dankook University

참고문헌

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피인용 문헌

  1. Weight Management as a Treatment Option for Gastroesophageal Reflux Disease: A Mechanical or Metabolic Rescuer? vol.12, pp.6, 2018, https://doi.org/10.5009/gnl18451
  2. 2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease vol.27, pp.4, 2018, https://doi.org/10.5056/jnm21077