Experimental and Molecular Medicine

Korean Society for Biochemistry and Molecular Biongy (생화학분자생물학회)
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The emerging role of lncRNAs in inflammatory bowel disease

  • Yarani, Reza (Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen) ;
  • Mirza, Aashiq H. (Department of Pharmacology, Weill Cornell Medicine, Cornell University) ;
  • Kaur, Simranjeet (Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen) ;
  • Pociot, Flemming (Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen)
  • Received : 2018.06.29
  • Accepted : 2018.09.11
  • Published : 2018.12.30
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Abstract

Dysregulation of long noncoding RNA (lncRNA) expression is linked to the development of various diseases. Recently, an emerging body of evidence has indicated that lncRNAs play important roles in the pathogenesis of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative Colitis (UC). In IBD, lncRNAs have been shown to be involved in diverse processes, including the regulation of intestinal epithelial cell apoptosis, association with lipid metabolism, and cell-cell interactions, thereby enhancing inflammation and the functional regulation of regulatory T cells. In this review, we aim to summarize the current knowledge regarding the role of lncRNAs in IBD and highlight potential avenues for future investigation. We also collate potentially immune-relevant, IBD-associated lncRNAs identified through a built-by association analysis with respect to their neighboring protein-coding genes within IBD-susceptible loci. We further underscore their importance by highlighting their enrichment for various aspects of immune system regulation, including antigen processing/presentation, immune cell proliferation and differentiation, and chronic inflammatory responses. Finally, we summarize the potential of lncRNAs as diagnostic biomarkers in IBD.

Keywords

Acknowledgement

Supported by : Independent Research Fund Denmark

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