Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Frequency of Red Blood Cell Antigens According to Parent Ethnicity in Korea Using Molecular Typing

  • Shin, Kyung-Hwa (Department of Laboratory Medicine, Pusan National University School of Medicine) ;
  • Lee, Hyun-Ji (Department of Laboratory Medicine, Pusan National University School of Medicine) ;
  • Kim, Hyung-Hoi (Department of Laboratory Medicine, Pusan National University School of Medicine) ;
  • Hong, Yun Ji (Department of Laboratory Medicine, Seoul National University Bundang Hospital) ;
  • Park, Kyoung Un (Department of Laboratory Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Min Ju (The Division of Human Blood Safety Surveillance, Korea Centers for Disease Control and Prevention) ;
  • Kwon, Jeong-Ran (Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention) ;
  • Choi, Young-Sil (Division of Laboratory Diagnosis Management, Korea Centers for Disease Control and Prevention) ;
  • Kim, Jun Nyun (The Division of Human Blood Safety Surveillance, Korea Centers for Disease Control and Prevention)
  • Received : 2017.11.13
  • Accepted : 2018.06.22
  • Published : 2018.11.01
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Abstract

Frequencies of red blood cell (RBC) blood group antigens differ by ethnicity. Since the number of immigrants is increasing in Korea, RBC antigens should be assessed in children/youths with parents of different ethnicities to ensure safe transfusions. We investigated the frequency of RBC antigens, except for ABO and RhD, in 382 children and youths with parents having Korean and non-Korean ethnicities. Subjects were divided into those with ethnically Korean parents (Korean group; N=252) and those with at least one parent of non-Korean ethnicity (non-Korean group; N=130). The 37 RBC antigens were genotyped using the ID CORE XT system (Progenika Biopharma-Grifols, Bizkaia, Spain). The frequencies of the Rh (E, C, e, $hr^S$, and $hr^B$), Duffy ($Fy^a$), MNS ($Mi^a$), and Cartwright ($Yt^b$) antigens differed significantly between the two groups. Eight and 11 subjects in the Korean and non-Korean groups, respectively, exhibited negative expression of high-frequency antigens, whereas 14 subjects in the non-Korean group showed positive expression of low-frequency antigens. The frequency of RBC antigens has altered alongside demographic changes in Korea and might lead to changes in distribution of RBC antibodies that cause acute or delayed hemolytic transfusion reaction.

Keywords

Acknowledgement

Supported by : Korea Centers for Disease Control and Prevention

References

  1. Han KS, Park KU, et al. Transfusion medicine. 4th ed. Seoul: Korean Medical Book Publisher, 2014:184-91.
  2. Shafi H, Abumuhor I, Klapper E. How we incorporate molecular typing of donors and patients into our hospital transfusion service. Transfusion 2014;54:1212-9. https://doi.org/10.1111/trf.12582
  3. Surendran SK, Allard S, Regan F. The management of third and fourth degree perineal tears. Royal College of Obstetricians and Gynaecologists Green Top Guidelines No 65. 2014. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-65.pdf (Updated on Jun 2018).
  4. Boccoz S, Blum L, Marquette C. DNA biosensor/biochip for multiplex blood group genotyping. Methods 2013;64:241-9. https://doi.org/10.1016/j.ymeth.2013.09.011
  5. Liu Z, Liu M, Mercado T, Illoh O, Davey R. Extended blood group molecular typing and next-generation sequencing. Transfus Med Rev 2014;28:177-86. https://doi.org/10.1016/j.tmrv.2014.08.003
  6. Goldman M, Nuria N, Castilho L. An overview of the Progenika ID CORE XT: an automated genotyping platform based on a fluidic microarray system. Immunohematology 2015;31:62-8.
  7. Goldman M, Cemborain A, Cote J, El Hamss R, Flower RL, Garaizar A, et al. Identification of six new RHCE variant alleles in individuals of diverse racial origin. Transfusion 2016;56:244-8. https://doi.org/10.1111/trf.13357
  8. Finning K, Bhandari R, Sellers F, Revelli N, Villa M. A, Muniz-Diaz E, et al. Evaluation of red blood cell and platelet antigen genotyping platforms (ID CORE XT/ID HPA XT) in routine clinical practice. Blood Transfus 2016;14:160-7.
  9. Lopez M, Apraiz I, Rubia M, Piedrabuena M, Azkarate M, Veldhuisen B, et al. Performance evaluation study of ID CORE XT, a high throughput blood group genotyping platform. Blood Transfus 2018;16:193-9.
  10. Kim KH, Kim BR, Choi JL, Woo KS, Kim JM, Han JY. Difference of Rh phenotype between irregular antibody positive patients and rhd positive population in Korea. Korean J Blood Transfus 2014;25:60-8.
  11. Lee NY SJ, Ryang DW, Son HC, Kwon KC, Yoo BJ. Discrepant frequency of Rh subtype and Kell blood group antigens between Korean pregnant women and their neonates. Korean J Blood Transfus 1998;9:37-43.
  12. Hong YJ, Chung Y, Hwang SM, Park JS, Kwon JR, Choi YS, et al. Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population. Ann Hematol 2016; 95:985-91. https://doi.org/10.1007/s00277-016-2645-7
  13. IT Strategy & Management Division of Ministry of Justice. Foreign residents. In: Korea Immigration Services Statistics 2016. Statistics Korea: 2016:38-9.
  14. Laura C and Theresa D. Immunohematology. In: Richard M, Matthew R, eds. Henry's clinical diagnosis and management by laboratory methods. 22nd ed. Philadelphia: Elsevier Saunders 2011:675-710.

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