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Comparison of Filtered Back Projection, Hybrid Iterative Reconstruction, Model-Based Iterative Reconstruction, and Virtual Monoenergetic Reconstruction Images at Both Low- and Standard-Dose Settings in Measurement of Emphysema Volume and Airway Wall Thickness: A CT Phantom Study

  • Kim, Cherry (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Lee, Ki Yeol (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Shin, Chol (Department of Pulmonology, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Kang, Eun-Young (Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Oh, Yu-Whan (Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine) ;
  • Ha, Moin (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Ko, Chang Sub (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Cha, Jaehyung (Department of Medical Science Research Center, Korea University Ansan Hospital, Korea University College of Medicine)
  • Received : 2017.08.15
  • Accepted : 2018.01.23
  • Published : 2018.08.01

Abstract

Objective: To evaluate the accuracy of emphysema volume (EV) and airway measurements (AMs) produced by various iterative reconstruction (IR) algorithms and virtual monoenergetic images (VME) at both low- and standard-dose settings. Materials and Methods: Computed tomography (CT) images were obtained on phantom at both low- (30 mAs at 120 kVp) and standard-doses (100 mAs at 120 kVp). Each CT scan was reconstructed using filtered back projection, hybrid IR ($iDose^4$; Philips Healthcare), model-based IR (IMR-R1, IMR-ST1, IMR-SP1; Philips Healthcare), and VME at 70 keV (VME70). The EV of each air column and wall area percentage (WA%) of each airway tube were measured in all algorithms. Absolute percentage measurement errors of EV ($APE_{vol}$) and AM ($APE_{WA%}$) were then calculated. Results: Emphysema volume was most accurately measured in IMR-R1 ($APE_{vol}$ in low-dose, $0.053{\pm}0.002$; $APE_{vol}$ in standard-dose, $0.047{\pm}0.003$; all p < 0.001) and AM was the most accurate in IMR-SP1 on both low- and standard-doses CT ($APE_{WA%}$ in low-dose, $0.067{\pm}0.002$; $APE_{WA%}$ in standard-dose, $0.06{\pm}0.003$; all p < 0.001). There were no significant differences in the $APE_{vol}$ of IMR-R1 between low- and standard-doses (all p > 0.05). VME70 showed a significantly higher $APE_{vol}$ than $iDose^4$, IMR-R1, and IMR-ST1 (all p < 0.004). VME70 also showed a significantly higher $APE_{WA%}$ compared with the other algorithms (all p < 0.001). Conclusion: IMR was the most accurate technique for measurement of both EV and airway wall thickness. However, VME70 did not show a significantly better accuracy compared with other algorithms.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF), Dong-Kook Pharmaceutical, Reyon Pharmaceutical and Philips Company, Korea University

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