Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Inter-Vendor and Inter-Session Reliability of Diffusion Tensor Imaging: Implications for Multicenter Clinical Imaging Studies

  • Min, Jeeyoung (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Park, Mina (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Choi, Jin Woo (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Jahng, Geon-Ho (Department of Radiology, Kyunghee University) ;
  • Moon, Won-Jin (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine)
  • Received : 2017.08.25
  • Accepted : 2017.12.11
  • Published : 2018.08.01
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Abstract

Objective: To evaluate the inter-vendor and inter-session reliability of diffusion tensor imaging (DTI) and relevant parameters. Materials and Methods: This prospective study included 10 healthy subjects (5 women and 5 men; age range, 25-33 years). Each subject was scanned twice using 3T magnetic resonance scanners from three different vendors at two different sites. A voxel-wise statistical analysis of diffusion data was performed using Tract-Based Spatial Statistics. Fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) values were calculated for each brain voxel using FMRIB's Diffusion Toolbox. Results: A repeated measures analysis of variance revealed that there were no significant differences in FA values across the vendors or between sessions; however, there were significant differences in MD values between the vendors (p = 0.020). Although there were no significant differences in inter-session MD and inter-session/inter-vendor RD values, a significant group x factor interaction revealed differences in MD and RD values between the 1st and 2nd sessions conducted by the vendors (p = 0.004 and 0.006, respectively). Conclusion: Although FA values exhibited good inter-vendor and inter-session reliability, MD and RD values did not show consistent results. Researchers using DTI should be aware of these limitations, especially when implementing DTI in multicenter studies.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare, National Research Foundation of Korea (NRF)

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