Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Clinical characteristics of lower respiratory tract infection in low birth weight children

저체중 출생아에서 급성 하부호흡기감염의 임상적 특징

  • Yoon, Yoonsun (Department of Pediatrics, Korea University College of Medicine) ;
  • Jung, Geehae (Department of Pediatrics, Korea University College of Medicine) ;
  • Ri, Soohyun (Department of Pediatrics, Korea University College of Medicine) ;
  • Choung, Ji Tae (Department of Pediatrics, Korea University College of Medicine) ;
  • Yoo, Young (Department of Pediatrics, Korea University College of Medicine)
  • 윤윤선 (고려대학교 의과대학 소아과학교실) ;
  • 정지혜 (고려대학교 의과대학 소아과학교실) ;
  • 이수현 (고려대학교 의과대학 소아과학교실) ;
  • 정지태 (고려대학교 의과대학 소아과학교실) ;
  • 유영 (고려대학교 의과대학 소아과학교실)
  • Received : 2017.10.12
  • Accepted : 2018.02.24
  • Published : 2018.07.31
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Abstract

Purpose: Lower respiratory tract infection (LRTI) is one of the most common causes of hospitalization in the pediatric population. In this study, we investigated the clinical characteristics of LRTI, particularly in low birth weight children. Methods: We reviewed medical records of children at ages 0-6 years with LRTI in Korea University Anam Hospital between January and December of 2014. Clinical data including age, sex, birth history, viral pathogens, blood test results, and clinical courses were collected. Results: In the 828 eligible cases, 617 (74.5%) were pneumonia and followed by bronchiolitis 180 (21.7%) and bronchitis 31 (3.7%). The median age of the subjects was 17 months (interquartile range [IQR], 7-28 months), the median gestational age was 39.0 weeks (IQR, 38.0-40.0 weeks) and the median birth weight was 3,200 g (IQR, 2,900-3,480 g). Sixty-four children (7.7%) were low birth weight (< 2,500 g) and their median gestational age and birth weight were 33.0 weeks (IQR, 30.0-36.0 weeks) and 2,045 g (IQR, 1,565-2,300 g), respectively. The rates of oxygen supplement (17.2% vs. 4.6%, P< 0.001) and systemic steroid use (20.3% vs. 4.7%, P< 0.001) were significantly higher in low birth weight children than normal birth weight children. Respiratory viruses were identified in 82.6% (519 of 628 subjects); RSV was detected in 240 subjects (38.2%), followed by rhinovirus 168 (26.8%) and adenoviruses 75 (11.9%). The distribution of respiratory viruses was not different between normal birth weight children and low birth weight children. Conclusion: Low birth weight children show more severe clinical manifestations than normal birth weight children during hospitalization for LRTI, although respiratory viral pathogens were not different. Clinicians should be aware that the severity may be increased when low birth weight children were hospitalized due to low respiratory tract infection.

Keywords

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