Allergy, Asthma & Respiratory Disease

  • 제6권4호
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  • Pages.206-210
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  • 2018
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  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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소아에서 respiratory syncytial virus 감염과 기후인자 및 대기오염물질과의 상관관계

Correlation of respiratory syncytial virus infection with climate parameters and air pollution levels in Korean children during 2005-2012

  • 정지현 (인제대학교 상계백병원 소아청소년과) ;
  • 곡수옥 (인제대학교 상계백병원 소아청소년과) ;
  • 김제연 (인제대학교 상계백병원 소아청소년과) ;
  • 한태희 (인제대학교 상계백병원 진단검사의학과) ;
  • 박상훈 (서울특별시 보건환경연구원 미생물학과) ;
  • 정주영 (인제대학교 상계백병원 소아청소년과) ;
  • 김효빈 (인제대학교 상계백병원 소아청소년과)
  • Jung, Ji-Hyun (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Chu, Shou-Yu (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Kim, Je-Yeon (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Han, Tae-Hee (Department of Diagnostic Laboratory Medicine, Inje University Sanggye Paik Hospital) ;
  • Park, Sang-Hun (Microbiology Division, Seoul Health Environment Research Center) ;
  • Chung, Ju-Young (Department of Pediatrics, Inje University Sanggye Paik Hospital) ;
  • Kim, Hyo-Bin (Department of Pediatrics, Inje University Sanggye Paik Hospital)
  • 투고 : 2018.01.22
  • 심사 : 2018.03.26
  • 발행 : 2018.07.31
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infection (LRTI) in infants and children. We investigated the association of meteorological conditions and air pollution with the prevalence of RSV infection. Methods: Between January 2005 and December 2012, a total of 9,113 nasopharyngeal swab specimens from children under 3 years of age who were admitted to the hospital with acute LRTI were tested for RSV antigens using a direct immunofluorescence kit. Meteorological data (mean temperature, precipitation, wind speed, and relative humidity) and air pollutant levels including $PM_{10}$ (particulate matter with a median aerodynamic diameter less than or equal to $10{\mu}m$ in diameter), nitrogen dioxide ($NO_2$), sulfur dioxide ($SO_2$), and carbon monoxide (CO) in Seoul during the study period were collected from the national monitoring system. The correlations of the monthly incidence of RSV infection with climate factors and air pollutant levels were analyzed. Results: RSV infection mainly occurred between October and February, and showed the peak in November. The prevalence of RSV infection had a moderate negative correlation with mean temperature (r=-0.60, P< 0.001), a weak negative correlation with relative humidity (r=-0.26, P=0.01), and precipitation (r=-0.34, P=0.001). Regarding air pollutants, RSV activity moderately correlated with $NO_2$ (r=0.40, P< 0.001), $SO_2$ (r=0.41, P< 0.001), and CO (r=0.58, P< 0.001). In the RSV peak season in Korea (between October and February), RSV epidemics showed a weak positive correlation with relative humidity (r=0.35, P=0.03) and precipitation (r=0.38, P=0.02). Conclusion: Meteorological factors and air pollutant levels may be associated with RSV activity. Therefore, further nationwide large-scaled intensive evaluations to prove factors affecting RSV activity are warranted.

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참고문헌

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