Clinical Nutrition Research

  • 제7권3호
  • /
  • Pages.170-177
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  • 2018
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  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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DOI QR코드

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Glycated Hemoglobin and Cancer Risk in Korean Adults: Results from Korean Genome and Epidemiology Study

  • Kim, Ji Young (Department of Public Health Sciences, Graduate School, Korea University) ;
  • Lee, Youn Sue (Korea National Enterprise for Clinical Trials) ;
  • Jo, Garam (Department of Public Health Sciences, Graduate School, Korea University) ;
  • Shin, Min-Jeong (Department of Public Health Sciences, Graduate School, Korea University)
  • 투고 : 2018.03.06
  • 심사 : 2018.04.09
  • 발행 : 2018.07.31
⟨ 이전 논문 다음 논문 ⟩

초록

The purpose of this study was to test whether elevated glycated hemoglobin A1c (HbA1c) levels are associated with cancer incidence in the Korean population. In cohorts of the Korea Genome and Epidemiology Study (KoGES) consortium, we tested whether plasma levels of HbA1c were associated with all-site cancer incidence in 7,822 participants without any known history of cancer or diabetes. Cancer developed in 117 participants during the follow-up period. Subjects were subdivided into 3 categories according observed levels of HbA1c (< 5.7%, low; ${\geq}5.7%$ and < 6.5%, mid; and ${\geq}6.5%$, high). The adjusted hazard ratio for all-site cancer was 3.03 (95% confidence intervals, 1.54-5.96) for the high HbA1c group relative to the low HbA1c group after adjusting for covariates. Higher circulating HbA1c levels were associated with an increased risk of all-site cancer in Korean population.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

참고문헌

  1. Shikata K, Ninomiya T, Kiyohara Y. Diabetes mellitus and cancer risk: review of the epidemiological evidence. Cancer Sci 2013;104:9-14. https://doi.org/10.1111/cas.12043
  2. American Cancer Society. Cancer facts & figures. Available from https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2016.html. 2016.
  3. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. Diabetes Care 2010;33:1674-85. https://doi.org/10.2337/dc10-0666
  4. Rapp K, Schroeder J, Klenk J, Ulmer H, Concin H, Diem G, Oberaigner W, Weiland SK. Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. Diabetologia 2006;49:945-52. https://doi.org/10.1007/s00125-006-0207-6
  5. Jian Gang P, Mo L, Lu Y, Runqi L, Xing Z. Diabetes mellitus and the risk of prostate cancer: an update and cumulative meta-analysis. Endocr Res 2015;40:54-61. https://doi.org/10.3109/07435800.2014.934961
  6. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33 Suppl 1:S62-9. https://doi.org/10.2337/dc10-S062
  7. Joshu CE, Prizment AE, Dluzniewski PJ, Menke A, Folsom AR, Coresh J, Yeh HC, Brancati FL, Platz EA, Selvin E. Glycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006. Int J Cancer 2012;131:1667-77. https://doi.org/10.1002/ijc.27394
  8. Hsu YC, Chiu HM, Liou JM, Chang CC, Lin JT, Liu HH, Wu MS. Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia. Cancer Causes Control 2012;23:321-8. https://doi.org/10.1007/s10552-011-9880-y
  9. Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundstrom J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gomez-de-la-Camara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Bjorkelund C, Blazer DG, Wassertheil-Smoller S, Onat A, Marin Ibanez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett-Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB Sr, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh JEmerging Risk Factors Collaboration. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA 2014;311:1225-33. https://doi.org/10.1001/jama.2014.1873
  10. Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med 2010;362:800-11. https://doi.org/10.1056/NEJMoa0908359
  11. Lin J, Ridker PM, Rifai N, Lee IM, Manson JE, Buring JE, Zhang SM. A prospective study of hemoglobin A1c concentrations and risk of breast cancer in women. Cancer Res 2006;66:2869-75. https://doi.org/10.1158/0008-5472.CAN-05-3922
  12. Wolpin BM, Bao Y, Qian ZR, Wu C, Kraft P, Ogino S, Stampfer MJ, Sato K, Ma J, Buring JE, Sesso HD, Lee IM, Gaziano JM, McTiernan A, Phillips LS, Cochrane BB, Pollak MN, Manson JE, Giovannucci EL, Fuchs CS. Hyperglycemia, insulin resistance, impaired pancreatic ${\beta}$-cell function, and risk of pancreatic cancer. J Natl Cancer Inst 2013;105:1027-35. https://doi.org/10.1093/jnci/djt123
  13. Zhang M, Li X, Zhang X, Yang Y, Feng Z, Liu X. Association of serum hemoglobin A1c, C-peptide and insulin-like growth factor-1 levels with the occurrence and development of lung cancer. Mol Clin Oncol 2014;2:506-8. https://doi.org/10.3892/mco.2014.289
  14. Dabrowski M. Glycated hemoglobin, diabetes treatment and cancer risk in type 2 diabetes. A case-control study. Ann Agric Environ Med 2013;20:116-21.
  15. Erickson K, Patterson RE, Flatt SW, Natarajan L, Parker BA, Heath DD, Laughlin GA, Saquib N, Rock CL, Pierce JP. Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol 2011;29:54-60.
  16. Xu J, Ye Y, Wu H, Duerksen-Hughes P, Zhang H, Li P, Huang J, Yang J, Wu Y, Xia D. Association between markers of glucose metabolism and risk of colorectal cancer. BMJ Open 2016;6:e011430. https://doi.org/10.1136/bmjopen-2016-011430
  17. Kim NH, Suh JY, Park JH, Park DI, Cho YK, Sohn CI, Choi K, Jung YS. Parameters of glucose and lipid metabolism affect the occurrence of colorectal adenomas detected by surveillance colonoscopies. Yonsei Med J 2017;58:347-54. https://doi.org/10.3349/ymj.2017.58.2.347
  18. Rojas A, Figueroa H, Morales E. Fueling inflammation at tumor microenvironment: the role of multiligand/RAGE axis. Carcinogenesis 2010;31:334-41. https://doi.org/10.1093/carcin/bgp322
  19. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008;454:436-44. https://doi.org/10.1038/nature07205
  20. Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle 2009;8:3267-73. https://doi.org/10.4161/cc.8.20.9699
  21. Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809. https://doi.org/10.1038/nrc2734
  22. Abe R, Yamagishi S. AGE-RAGE system and carcinogenesis. Curr Pharm Des 2008;14:940-5. https://doi.org/10.2174/138161208784139765
  23. Lee JH, Yoon SR, Na GY, Jun M, Ahn MR, Cha JK, Kim OY. Fasting glucose is a useful indicator for cerebrovascular risk in non-diabetic Koreans: association with oxidative stress and inflammation. Clin Nutr Res 2016;5:33-42. https://doi.org/10.7762/cnr.2016.5.1.33
  24. Bunn HF, Gabbay KH, Gallop PM. The glycosylation of hemoglobin: relevance to diabetes mellitus. Science 1978;200:21-7. https://doi.org/10.1126/science.635569
  25. Yoon SR, Lee JH, Na GY, Seo YJ, Han S, Shin MJ, Kim OY. Glycated hemoglobin is a better predictor than fasting glucose for cardiometabolic risk in non-diabetic Korean women. Clin Nutr Res 2015;4:97-103. https://doi.org/10.7762/cnr.2015.4.2.97
  26. Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG, Lee JS. Cancer statistics in Korea: incidence, mortality, survival and prevalence in 2010. Cancer Res Treat 2013;45:1-14. https://doi.org/10.4143/crt.2013.45.1.1
  27. Kim DJ. The epidemiology of diabetes in Korea. Diabetes Metab J 2011;35:303-8. https://doi.org/10.4093/dmj.2011.35.4.303

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