Journal of Cardiovascular Imaging

  • 제26권2호
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  • Pages.75-84
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  • 2018
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
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Correlation between Echocardiographic Pulmonary Artery Pressure Estimates and Right Heart Catheterization Measurement in Liver Transplant Candidates

  • Habash, Fuad (Department of Cardiology, University of Arkansas for Medical Sciences) ;
  • Gurram, Pooja (Department of Cardiology, University of Arkansas for Medical Sciences) ;
  • Almomani, Ahmed (Department of Cardiology, University of Arkansas for Medical Sciences) ;
  • Duarte, Andres (Department of Cardiology, University of Arkansas for Medical Sciences) ;
  • Hakeem, Abdul (Department of Cardiology, University of Arkansas for Medical Sciences) ;
  • Vallurupalli, Srikanth (Department of Cardiology, University of Arkansas for Medical Sciences) ;
  • Bhatti, Sabha (Department of Cardiology, University of Arkansas for Medical Sciences)
  • 투고 : 2018.02.19
  • 심사 : 2018.04.13
  • 발행 : 2018.06.27
⟨ 이전 논문 다음 논문 ⟩

초록

BACKGROUND: Patients undergoing liver transplant have worse outcomes in the presence of pulmonary hypertension. Correlation between echocardiography and catheterization derived pressures in this population is not well studied. Our study's aim is to show the relationship between pulmonary artery systolic pressure derived from transthoracic echo (ePASP) with pulmonary artery systolic pressure measured during right heart catheterization (cPASP). METHODS: Single center retrospective study, patients being evaluated for liver transplant (n = 31) who had an interpretable Doppler signal for ePASP and had right heart catheterization (RHC) measurements within 3 months constituted the study group. Control group (n = 49) consisted of patients who did not have liver disease. RESULTS: There was modest correlation between ePASP and cPASP (R = 0.58, p < 0.001) in LT candidates (n = 31) compared with the control group (R = 0.74, p < 0.001, n = 49). The 95% limits of agreement by Bland-Altman analysis ranged from +33.6 mmHg to -21.7 mmHg. Using receiver operating characteristic analysis, ePASP cut-off > 47 mmHg was 59% sensitive and 78% specific to diagnose pulmonary artery (PA) hypertension (mean PA pressure > 25 mmHg) in the LT candidates, while a similar cutoff performed well in the control group (cutoff > 43 mmHg, n = 47, 91% sensitive, 100% specific). CONCLUSIONS: Compared with other disease states, ePASP correlates modestly with cPASP in patients with advanced liver disease. A higher ePASP cutoff should be used to screen for pulmonary hypertension. A multi-center prospective study with simultaneous transthoracic echocardiography and RHC measurements is required to determine the best cut-off in this population.

키워드

참고문헌

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피인용 문헌

  1. Intraoperative anesthetic management of the liver transplant recipient with portopulmonary hypertension vol.24, pp.2, 2018, https://doi.org/10.1097/mot.0000000000000613
  2. Noninvasive estimation of pulmonary vascular resistance improves portopulmonary hypertension screening in liver transplant candidates vol.33, pp.7, 2018, https://doi.org/10.1111/ctr.13585
  3. Role of echocardiography in screening for portopulmonary hypertension in liver transplant candidates: a meta-analysis vol.8, pp.None, 2020, https://doi.org/10.7717/peerj.9243
  4. Performance of echocardiography for detection of portopulmonary hypertension among liver transplant candidates: Meta‐analysis vol.34, pp.11, 2020, https://doi.org/10.1111/ctr.13995