DOI QR코드

DOI QR Code

Genome-Based Virus Taxonomy with the ICTV Database Extension

  • Received : 2018.05.17
  • Accepted : 2018.12.23
  • Published : 2018.12.31

Abstract

In 1966, the International Classification of Viruses (ICNV) was established to standardize the naming of viruses. In 1975, the organization was renamed "International Committee on Taxonomy of Viruses (ICTV)," by which it is still known today. The primary virus classification provided by ICTV in 1971 was for viruses infecting vertebrates, which includes 19 genera, 2 families, and 24 unclassified groups. Presently, the 10th virus taxonomy has been published. However, the early classification of viruses was based on clinical results "in vivo" and "in vitro," as well as on the shape of the Phenotype virus. Due to the development of next-generation sequencing and the accompanying bioinformatics analysis pipelines, a reconstruction of the classification system has been proposed. At a meeting held in Boston, USA between June 9-11, 2016, there was even an in-depth discussion regarding the classification of viruses using metagenomic data. One suggested activity that arose from the meeting was that viral taxonomy should be reconstructed, based on genotype and bioinformatics analysis "in silico." This article describes our efforts to achieve this goal by construction of a web-based system and the extension of an associated database, based on ICTV taxonomy. This virus taxonomy web system was designed specifically to extend the virus taxonomy up to strain and isolation, which was then connected with the NCBI database to facilitate searches for specific viral genes; there are also links to journals provided by the EMBL RESTful API that improves accessibility for academic groups.

Keywords

References

  1. Benson DA, Cavanaugh M, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J, et al. GenBank. Nucleic Acids Res 2013;41:D36-D42. https://doi.org/10.1093/nar/gks1035
  2. Simmonds P. Methods for virus classification and the challenge of incorporating metagenomic sequence data. J Gen Virol 2015;96:1193-1206. https://doi.org/10.1099/vir.0.000016
  3. Cientific S, Atabases D. The universal virus database ictvdb. Syst Zool 1974;23:50-57. https://doi.org/10.2307/2412239
  4. Adams MJ, Lefkowitz EJ, King AM, Harrach B, Harrison RL, Knowles NJ, et al. 50 years of the International Committee on Taxonomy of Viruses: progress and prospects. Arch Virol 2017;162:1441-1446. https://doi.org/10.1007/s00705-016-3215-y
  5. Lefkowitz EJ, Dempsey DM, Hendrickson RC, Orton RJ, Siddell SG, Smith DB. Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV). Nucleic Acids Res 2018;46:D708-D717. https://doi.org/10.1093/nar/gkx932
  6. Lopez R, Cowley A, Li W, McWilliam H. Using EMBL-EBI services via web interface and programmatically via web services. Curr Protoc Bioinformatics 2014;48:3.12.1-3.12.50.
  7. McEntyre J. Linking up with Entrez. Trends Genet 1998;14:39-40. https://doi.org/10.1016/S0168-9525(97)01325-5
  8. Simmonds P, Adams MJ, Benko M, Breitbart M, Brister JR, Carstens EB, et al. Consensus statement: virus taxonomy in the age of metagenomics. Nat Rev Microbiol 2017;15:161-168. https://doi.org/10.1038/nrmicro.2016.177