Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Current clinical applications of platelet-rich plasma in various gynecological disorders: An appraisal of theory and practice

  • Received : 2018.02.10
  • Accepted : 2018.05.25
  • Published : 2018.06.30
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Abstract

The purpose of this paper is to review the current clinical uses of platelet-rich plasma (PRP) in the field of gynecology. All relevant articles published from January 2000 to December 2017 were reviewed and analyzed. The articles on PRP in the field of gynecology were mainly case series, pilot studies, or case reports. PRP is currently considered a new therapeutic modality for some disorders that are refractory to conventional drugs.

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References

  1. Dhillon RS, Schwarz EM, Maloney MD. Platelet-rich plasma therapy: future or trend? Arthritis Res Ther 2012;14:219. https://doi.org/10.1186/ar3914
  2. Everts PA, Hoogbergen MM, Weber TA, Devilee RJ, van Monftort G, de Hingh IH. Is the use of autologous platelet-rich plasma gels in gynecologic, cardiac, and general, reconstructive surgery beneficial? Curr Pharm Biotechnol 2012;13:1163-72. https://doi.org/10.2174/138920112800624346
  3. Lai LP, Stitik TP, Foye PM, Georgy JS, Patibanda V, Chen B. Use of platelet-rich plasma in intra-articular knee injections for osteoarthritis: a systematic review. PM R 2015;7:637-48. https://doi.org/10.1016/j.pmrj.2015.02.003
  4. Wang SZ, Chang Q, Lu J, Wang C. Growth factors and plateletrich plasma: promising biological strategies for early intervertebral disc degeneration. Int Orthop 2015;39:927-34. https://doi.org/10.1007/s00264-014-2664-8
  5. Amable PR, Carias RB, Teixeira MV, da Cruz Pacheco I, Correa do Amaral RJ, Granjeiro JM, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther 2013;4:67. https://doi.org/10.1186/scrt218
  6. Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author's perspective. J Cutan Aesthet Surg 2014;7:189-97. https://doi.org/10.4103/0974-2077.150734
  7. Anitua E, Sanchez M, Orive G. The importance of understanding what is platelet-rich growth factor (PRGF) and what is not. J Shoulder Elbow Surg 2011;20:e23-4.
  8. Dohan Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J 2014;4:3-9.
  9. Dohan Ehrenfest DM, Bielecki T, Mishra A, Borzini P, Inchingolo F, Sammartino G, et al. In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes. Curr Pharm Biotechnol 2012;13:1131-7. https://doi.org/10.2174/138920112800624328
  10. Mishra A, Harmon K, Woodall J, Vieira A. Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol 2012;13:1185-95. https://doi.org/10.2174/138920112800624283
  11. Magalon J, Chateau AL, Bertrand B, Louis ML, Silvestre A, Giraudo L, et al. DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med 2016;2:e000060. https://doi.org/10.1136/bmjsem-2015-000060
  12. Jo CH, Roh YH, Kim JE, Shin S, Yoon KS. Optimizing platelet-rich plasma gel formation by varying time and gravitational forces during centrifugation. J Oral Implantol 2013;39:525-32. https://doi.org/10.1563/AAID-JOI-D-10-00155
  13. International Cellular Medicine Society. Platelet Rich plasma (PRP) guidelines [Internet]. Las Vegas: International Cellular Medicine Society; 2011 [cited 2018 Jun 18]. Available from: http://www.cellmedicinesociety.org/icms-guidelines/guidelines.
  14. Sundman EA, Cole BJ, Karas V, Della Valle C, Tetreault MW, Mohammed HO, et al. The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis. Am J Sports Med 2014;42:35-41. https://doi.org/10.1177/0363546513507766
  15. Sunitha Raja V, Munirathnam Naidu E. Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent Res 2008;19:42-6. https://doi.org/10.4103/0970-9290.38931
  16. Tehranian A, Esfehani-Mehr B, Pirjani R, Rezaei N, Sadat Heidary S, Sepidarkish M. Application of autologous platelet-rich plasma (PRP) on wound healing after caesarean section in high-risk patients. Iran Red Crescent Med J 2016;18:e34449.
  17. Fanning J, Murrain L, Flora R, Hutchings T, Johnson JM, Fenton BW. Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery. J Minim Invasive Gynecol 2007;14:633-7. https://doi.org/10.1016/j.jmig.2007.05.014
  18. Hua X, Zeng Y, Zhang R, Wang H, Diao J, Zhang P. Using plateletrich plasma for the treatment of symptomatic cervical ectopy. Int J Gynaecol Obstet 2012;119:26-9.
  19. Casabona F, Priano V, Vallerino V, Cogliandro A, Lavagnino G. New surgical approach to lichen sclerosus of the vulva: the role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration. Plast Reconstr Surg 2010;126:210e-211e. https://doi.org/10.1097/PRS.0b013e3181ea9386
  20. Behnia-Willison F, Pour NR, Mohamadi B, Willison N, Rock M, Holten IW, et al. Use of platelet-rich plasma for vulvovaginal autoimmune conditions like lichen sclerosus. Plast Reconstr Surg Glob Open 2016;4:e1124. https://doi.org/10.1097/GOX.0000000000001124
  21. Morelli M, Rocca ML, Venturella R, Di Cello A, Del Negro S, Condorelli M, et al. Adjuvant use of platelet gel for wound breakdown prevention in advanced vulvar cancer surgery: a retrospective study. Int J Gynecol Cancer 2013;23:1490-4. https://doi.org/10.1097/IGC.0b013e3182a50517
  22. Bodner-Adler B, Hanzal E, Pablik E, Koelbl H, Bodner K. Management of vesicovaginal fistulas (VVFs) in women following benign gynaecologic surgery: a systematic review and meta-analysis. PLoS One 2017;12:e0171554. https://doi.org/10.1371/journal.pone.0171554
  23. Shirvan MK, Alamdari DH, Ghoreifi A. A novel method for iatrogenic vesicovaginal fistula treatment: autologous platelet rich plasma injection and platelet rich fibrin glue interposition. J Urol 2013;189:2125-9. https://doi.org/10.1016/j.juro.2012.12.064
  24. Mongardini M, Iachetta RP, Cola A, Maturo A, Giofre M, Custureri F. Low rectovaginal fistula treated with platelet-rich plasma (PRP). G Chir 2009;30:507-9.
  25. Gottgens KW, Smeets RR, Stassen LP, Beets GL, Pierik M, Breukink SO. Treatment of Crohn's disease-related high perianal fistulas combining the mucosa advancement flap with platelet-rich plasma: a pilot study. Tech Coloproctol 2015;19:455-9. https://doi.org/10.1007/s10151-015-1311-8
  26. Gorlero F, Glorio M, Lorenzi P, Bruno-Franco M, Mazzei C. New approach in vaginal prolapse repair: mini-invasive surgery associated with application of platelet-rich fibrin. Int Urogynecol J 2012;23:715-22. https://doi.org/10.1007/s00192-012-1667-5
  27. Medel S, Alarab M, Kufaishi H, Drutz H, Shynlova O. Attachment of primary vaginal fibroblasts to absorbable and nonabsorbable implant materials coated with platelet-rich plasma: potential application in pelvic organ prolapse surgery. Female Pelvic Med Reconstr Surg 2015;21:190-7. https://doi.org/10.1097/SPV.0000000000000178
  28. Chrysanthopoulou EL, Pergialiotis V, Perrea D, Κourkoulis S, Verikokos C, Doumouchtsis SK. Platelet rich plasma as a minimally invasive approach to uterine prolapse. Med Hypotheses 2017;104:97-100. https://doi.org/10.1016/j.mehy.2017.05.018
  29. Nikolopoulos KI, Pergialiotis V, Perrea D, Doumouchtsis SK. Restoration of the pubourethral ligament with platelet rich plasma for the treatment of stress urinary incontinence. Med Hypotheses 2016;90:29-31. https://doi.org/10.1016/j.mehy.2016.02.019
  30. Einarsson JI, Jonsdottir K, Mandle R. Use of autologous platelet gel in female pelvic organ prolapse surgery: a feasibility study. J Minim Invasive Gynecol 2009;16:204-7. https://doi.org/10.1016/j.jmig.2008.12.012
  31. White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med 2012;18:413-21. https://doi.org/10.1038/nm.2669
  32. Pantos K, Nitsos N, Kokkali G, Vaxevanoglou T, Markomichali C, Pantou A, et al. Ovarian rejuvenation and folliculogenesis reactivation in peri-menopausal women after autologous plateletrich plasma treatment. Proceedings of the 32nd Annual Meeting of ESHRE; 2016 July 3-6; Helsinki, Finland.
  33. Bakacak M, Bostanci MS, Inanc F, Yaylali A, Serin S, Attar R, et al. Protective effect of platelet rich plasma on experimental ischemia/reperfusion injury in rat ovary. Gynecol Obstet Invest 2016;81:225-31.
  34. Garcia-Velasco JA, Acevedo B, Alvarez C, Alvarez M, Bellver J, Fontes J, et al. Strategies to manage refractory endometrium: state of the art in 2016. Reprod Biomed Online 2016;32:474-89. https://doi.org/10.1016/j.rbmo.2016.02.001
  35. Colombo GV, Fanton V, Sosa D, Criado Scholz E, Lotti J, Aragona SE, et al. Use of platelet rich plasma in human infertility. J Biol Regul Homeost Agents 2017;31(2 Suppl. 2):179-82.
  36. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod 2017;21:54-6.
  37. Jang HY, Myoung SM, Choe JM, Kim T, Cheon YP, Kim YM, et al. Effects of autologous platelet-rich plasma on regeneration of damaged endometrium in female rats. Yonsei Med J 2017;58:1195-203. https://doi.org/10.3349/ymj.2017.58.6.1195
  38. Salehpour S, Zamaniyan M, Saharkhiz N, Zadeh Modares S, Hosieni S, Seif S, et al. Does intrauterine saline infusion by intrauterine insemination (IUI) catheter as endometrial injury during IVF cycles improve pregnancy outcomes among patients with recurrent implantation failure? An RCT. Int J Reprod Biomed (Yazd) 2016;14:583-8. https://doi.org/10.29252/ijrm.14.9.583
  39. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 2015;8:1286-90.
  40. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Ajori L. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: a pilot study. Int J Reprod Biomed (Yazd) 2016;14:625-8. https://doi.org/10.29252/ijrm.14.10.625
  41. Jin R, Zhang L, Zhang YG. Does platelet-rich plasma enhance the survival of grafted fat? An update review. Int J Clin Exp Med 2013;6:252-8.
  42. Gentile P, Di Pasquali C, Bocchini I, Floris M, Eleonora T, Fiaschetti V, et al. Breast reconstruction with autologous fat graft mixed with platelet-rich plasma. Surg Innov 2013;20:370-6. https://doi.org/10.1177/1553350612458544
  43. Salgarello M, Visconti G, Rusciani A. Breast fat grafting with platelet-rich plasma: a comparative clinical study and current state of the art. Plast Reconstr Surg 2011;127:2176-85. https://doi.org/10.1097/PRS.0b013e3182139fe7
  44. Ramos-E-Silva M, Fonteles LA, Lagalhard CS, Fucci-da-Costa AP. $Stylage^{(R)}$: a range of hyaluronic acid dermal fillers containing mannitol: physical properties and review of the literature. Clin Cosmet Investig Dermatol 2013;6:257-61.
  45. Jain A, Bedi RK, Mittal K. Platelet-rich plasma therapy: a novel application in regenerative medicine. Asian J Transfus Sci 2015;9: 113-4. https://doi.org/10.4103/0973-6247.162679
  46. Runels C, Melnick H, Debourbon E, Roy L. A pilot study of the effect of localized injections of autologous platelet rich plasma (PRP) for the treatment of female sexual dysfunction. J Womens Health Care 2014;3:169.
  47. Ruth Styles. Would you plump up your vagina with fillers? Top cosmetic doctor warns of risky new trend after being inundated with clients looking for 'genital enhancements' [Internet]. London: Daily Mail; 2015 [cited 2018 Jun 17]. Available from: http://www.dailymail.co.uk/femail/article-3114937/Top-cosmeticdoctor-warns-risky-new-trend-genital-filler-jabs.html.
  48. Kim SH, Park ES, Kim TH. Rejuvenation using platelet-rich plasma and lipofilling for vaginal atrophy and lichen sclerosus. J Menopausal Med 2017;23:63-8. https://doi.org/10.6118/jmm.2017.23.1.63
  49. Lewi L, Liekens D, Heyns L, Poliard E, Beutels E, Deprest J, et al. In vitro evaluation of the ability of platelet-rich plasma to seal an iatrogenic fetal membrane defect. Prenat Diagn 2009;29:620-5. https://doi.org/10.1002/pd.2249

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