대한암한의학회지 (Journal of Korean Traditional Oncology)

  • 제23권1호
  • /
  • Pages.33-43
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  • 2018
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  • 1975-244X(pISSN)
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  • 2765-4850(eISSN)
대한암한의학회 (Korean Association of Traditional Oncology)
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유방암 환자의 cyclophosphamide, doxorubicin 유발 부작용에 대한 약침을 포함한 통합 암 치료 1례

A Case Report of Cyclophosphamide plus Doxorubicin-induced Side effects in Patient with Both Sides Breast Cancer Treated with Integrative Medicine Therapy Including Pharmacopuncture.

  • 김민서 (동의대학교병원 부속 한방병원 한방내과) ;
  • 정유진 (동의대학교병원 부속 한방병원 한방내과) ;
  • 홍상훈 (동의대학교병원 부속 한방병원 한방내과)
  • Kim, Minserh (Department of Korean Internal Medicine, Dong-eui University Hospital at Busan) ;
  • Jung, Yu-jin (Department of Korean Internal Medicine, Dong-eui University Hospital at Busan) ;
  • Hong, Sang-hoon (Department of Korean Internal Medicine, Dong-eui University Hospital at Busan)
  • 발행 : 2018.06.30
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초록

Objectives: To observe the mitigating effects of a Traditional Korean Medicine(TKM) treatment program especially including pharmacopuncture, with Cyclophosphamide and doxorubicin chemotherapy on a both sides breast cancer patient. Methods: AA 74 year-old female patient diagnosed with both sides breast cancer (Right) pT1bpN0M0, (Left) pT1cpN1Mx was admitted to hospital of Dong-eui university in May of 2017. She received Cyclophosphamide and Doxorubicin from May $31^{st}$ to August $2^{nd}$, 2017 followed by TKM treatment consisting of herbal medicine, acupuncture, moxibustion and pharmacopuncture (Trionycis Carapax, Non-toxic Bee Venom, and Cultivated Wild Ginseng Extract) for a period of almost 4 months, from May $13^{th}$ to August $19^{th}$, 2017. Symptoms were evaluated by the grade of chief complaints refer to Common Terminology Criteria for Adverse Events (CTCAE) and Eastern Cooperative Oncology Group (ECOG). Results: TKM including pharmacopuncture alleviated chemotherapy-induced nausea, fatigue, joint pain, diarrhea, insomnia. Conclusions: This case study potentiates TKM with pharmacopuncture's significant efficacy in aiding breast cancer patients suffering from Cyclophosphamide plus Doxorubicin induced adverse effects. Further research should take place for clear understanding of the exact amount of dosage and safety. Moreover it must be accompanied by long-term follow up researches.

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참고문헌

  1. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2015, Ministry of Health and Welfare, 2017
  2. Early Breast Cancer Trialists' Collaborative Group. Favorable and unfavorable effects on long-term survival of radiotherapy for early breast cancer: and overview of the randomized trials. Lancet 355: 1757-1770, 2000. https://doi.org/10.1016/S0140-6736(00)02263-7
  3. Fisher B, Brown AM, Dimitrov NV, Poisson R, Redmond C, Margolese RG, et al. Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15. J Clin Oncol 8:1483-96, 1990 https://doi.org/10.1200/JCO.1990.8.9.1483
  4. Levine MN, Bramwell VH, Pritchard KI, Norris BD, Shepherd LE, Abu-Zahra H, et al. Randomized trial of intensive cyclophosphamide, epirubicin, and fluorouracil chemotherapy compared with cyclophosphamide, methotrexate, and fluorouracil in premenopausal women with node -positive breast cancer. National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 16:2651-8, 1998 https://doi.org/10.1200/JCO.1998.16.8.2651
  5. Kim HS. Toxicity and tolerability of the TAC regimen for adjuvant chemotherapy among Korean breast cancer patients. Department of Medicine Graduate school of Soonchunhyang University Asan, Korea. 2010.
  6. Jeong YJ, Park YS, Kwon HJ, Shin IH, Bong JG, Park SH, Acupunture for the Treatment of Hot Flashes in Patients with Breast Cancer Receiving Antiestrogen Therapy: A pilot study in Korean Women, J Altern Complement Med. 2013 Feb 5.
  7. Park SJ, Joo JC, Analysis of Case Report Related with Mountain Ginseng Phamacopuncture in Korean Medical Database, J of Kor. Traditional Oncology. 20(2), 51-59, 2015 https://doi.org/10.15432/JKTO.2015.20.2.051
  8. Han GJ, Lee AR, Jung JS, Seong S, Kim SS, A case study of a Patient with Breast Cancer Treated with a Combination of Traditional Korean Medicine and Chemotherapy. J.Int Korean Med. 38(5):820-827, 2017 https://doi.org/10.22246/jikm.2017.38.5.820
  9. Hwang YK, Kim WI, Kim KR, Clinical Effects of ByeolGab Pharmacopuncture for Primary Headache in Three Case Reports, J. Int. Korean medicine, 38(5):834-841, 2017 https://doi.org/10.22246/jikm.2017.38.5.834
  10. Hwang YK, Jung TG, Cho SW, Kim WI, A Study on Safety Assessment and VAS Change Observation Before and After Non-toxic Bee Venom Treatment in Pain Patients Using Questionnaire: Retrospective Chart Review. Journal of Korean Medicine Rehabilitation 27(1), 2017
  11. Available from: URL: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf
  12. Giantonio BJ, Forastiere AA, Comis RL, The role of the Eastern Cooperative Oncology Group in establishing standards of cancer care: over 50 years of progress through clinical research. Semin Oncol 35(5):494-506, 2008 https://doi.org/10.1053/j.seminoncol.2008.07.004
  13. Park JH, Bae SH, Jung YM, Changes of Symptom Distress and Quality of Life in Breast Cancer Patients Receiving Adjuvant Therapy, Asian Oncol Nurs, 15(2):67-74,2015 https://doi.org/10.5388/aon.2015.15.2.67
  14. 許浚. 東醫寶鑑. p683, 경남, 동의보감출판사, 2006.
  15. 최용태, 침구학(하). p1264-1265, 1457-1467, 서울집문당, 1993.
  16. Bae YH, Lee CH, Kim HS, Kim HS, Suh CY, KIm NH, Song JH, Yeom SC, A Case Report of Harpagophyti radix Pharmacopuncture for th Patient with Breast Cancer Trasnpered to Spine, The Journal of Korea CHUNA Manual Medicine for Spine & Nerves 10(1):117-127, 2015
  17. Lee TW, Anticancer Effect of Tissue Cultured Mountain Panax Ginseng Extract on Various Cancer Cell Lines, Graduate school of Chungbuk University, 2006.
  18. Choi KU, Protective Effect of the Water Extract of Tissue Cultured Root of Wild Ginseng against Doxorubicin Toxicity, Dept. of Oriental Medicine Semyung University Graduate School, 2008.
  19. 특허 제 10-20100118781호
  20. 특허 제 10-1774197호
  21. Choi JS, Park JW, Oh MS, The Review on the Study related to Anti-inflammatory Mechanism of Bee Venom Therapy, Dept. fo Oriental Rehabilitation Medicine, College of Oriental Medicine, Graduate school of Daejeon University, 15(1):141-159, 2006
  22. Choi CH, Song HS, Melittin Inhibits DU-145 Human Refractory Prostate Cancer Cell Growth Through Induction of Apoptosis Via Inactivation of NF-${\kappa}B$, The Acupuncture, 26(3):39-48, 2009
  23. Woo HD, Kim HS, Lee JH, Kim HM, Han SW, Kim SY, et al. Toxicity and Tolerability Study of Adjuvant TAC Regimen Chemotherapy in Korean Patients with Breast Cancer. J Breast Cancer 14(s):44-9, 2011 https://doi.org/10.4048/jbc.2011.14.S.S44
  24. Markman M. Managing taxanetoxicities, Support Care Cancer, 11:144-147, 2003
  25. Braverman AS, Rao S,Salvatti ME.Tapering and discontinuation of glucocorticoid prophylaxis during prolonged weekly to biweekly paclitaxel administration. Chemotherapy, 51:116-119, 2005. https://doi.org/10.1159/000085618