대한암한의학회지 (Journal of Korean Traditional Oncology)

  • 제23권1호
  • /
  • Pages.1-14
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  • 2018
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  • 1975-244X(pISSN)
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  • 2765-4850(eISSN)
대한암한의학회 (Korean Association of Traditional Oncology)
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체계적 문헌 고찰과 델파이 기법을 활용한 위암의 한약 치료에 관한 한의표준임상진료 지침 개발

Development of a Guidelines of the Herbal Medicine Treatment for Gastric Cancer on the Use of Systemic Review and Delphi Technique

  • 송시연 (대전대학교 둔산한방병원 동서암센터) ;
  • 반경태 (대전대학교 둔산한방병원 동서암센터) ;
  • 하수정 (대전대학교 둔산한방병원 동서암센터) ;
  • 박소정 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 조성훈 (경희대학교 한의과대학 한방신경정신과) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Song, Si Yeon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Ban, Kyung-tae (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Ha, Su-jeung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Park, So-jung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Lee, Yeon-weol (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Chong-kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Seung-Hun (Department of Neuropsychiatry, College of Korean Medicine, Kyunghee University) ;
  • Yoo, Hwa-Seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • 발행 : 2018.06.30
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초록

Objectives: This study was conducted towards developing guidelines of herbal medicine treatment for gastric cancer. Methods: We performed a systematic review and meta-analysis designed to investigate the efficacy of herbal medicine treatment for gastric cancer on four cancer questions; survival rate, metastasis, immune function, and quality of life. Based on the findings, we utilized a two-round delphi process with panel of 22 experts for their level of agreement. Results: Combined therapy group, herbal medicine treated with chemotherapy, was significantly higher in the 1-year survival rate (RR=1.27, 95% CI: 1.14 to 1.40, P=0.005, $I^2=71%$) and 3-years survival rate (RR=1.41, 95% CI: 1.16 to 1.71, P=0.91, $I^2=0%$) than chemotherapy group. The suppression of metastasis was higher in the combined therapy group (RR=0.62, 95% CI: 0.45 to 0.84, P=0.09, $I^2=54%$). The immunology function was higher in the combined therapy group compared with the chemotherapy group (MD=16.43, 95% CI: 13.25 to 29.61, P<0.001, $I^2=99%$). The quality of life score was higher in the combined therapy group compared with the chemotherapy group (RR=1.55, 95% CI: 1.21 to 2.00, P<0.66, $I^2=0%$). Conclusions: Among the Randomized controlled trials (RCT) included, the levels of survival rates, suppression of metastasis, immune function, and quality of life of the group treated with chemotherapy were lower compared to those treated with herbal medicine in addition to chemotherapy.

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