The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus

  • Son, Chang-Nam (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Lee, Tae-Han (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Bang, Ji-Hye (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Jeong, Hye-Jin (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Chae, Jin-Nyeong (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Lee, Won-Mok (Department of Laboratory Medicine, Keimyung University School of Medicine) ;
  • Kim, Ji-Min (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Kim, Sang-Hyon (Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine)
  • Received : 2016.02.15
  • Accepted : 2016.05.03
  • Published : 2018.07.01
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Abstract

Background/Aims: Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE. Methods: This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE. Results: The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls ($11.3{\pm}5.6{\mu}g/mL$ vs. $9.1{\pm}2.8{\mu}g/mL$). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers. Conclusions: These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.

Keywords

References

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