Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Development of fluorination methodology for carbon-fluorine bond formation: old electrophilic fluorinating reagents

  • Bae, Dae Young (Department of Chemistry, Pohang University of Science and Technology) ;
  • Lee, Eunsung (Department of Chemistry, Pohang University of Science and Technology)
  • Received : 2017.12.12
  • Accepted : 2018.06.29
  • Published : 2018.06.30
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Abstract

Electrophilic fluorinating reagents are typically efficient for carbon-fluorine (C-F) bonds formation due to their higher reactivity even under mild condition. Thus, they have been playing an important role to improve C-F bonds formation reactions via direct fluorination reaction with electrophilic fluorinating reagents or transition metal catalysis. Advances on the recent fluorination methods are mainly results of $Selectfluor^{TM}$'s capability on facile fluorination. In this mini-review, we describe synthesis and application of four old yet popular electrophilic fluorinating reagents such as N-fluorobenzenesulfonimide (NFSI), N-fluoropyridinium salts, $Selectfluor^{TM}$, and N-fluorosultam.

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References

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