Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Clinical features of eczema herpeticum in atopic dermatitis in a single center

아토피피부염 환자에서 포진습진의 임상 특징: 단일 기관 연구

  • Jang, Hyun Ji (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Rho, Young Eun (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Kwanghoon (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Seong Heon (Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University School of Medicine) ;
  • Kim, Young Mi (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Hye-Young (Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine)
  • 장현지 (부산대학교병원 소아청소년과) ;
  • 노영은 (부산대학교병원 소아청소년과) ;
  • 김광훈 (부산대학교병원 소아청소년과) ;
  • 김성헌 (부산대학교 어린이병원 소아청소년과) ;
  • 김영미 (부산대학교병원 소아청소년과) ;
  • 김혜영 (부산대학교병원 소아청소년과)
  • Received : 2017.10.31
  • Accepted : 2018.02.28
  • Published : 2018.05.31
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Abstract

Purpose: This study evaluated the clinical characteristics and risk factors associated with atopic dermatitis patients complicated by eczema herpeticum. Methods: This study included 45 patients under the age of 18 with atopic dermatitis complicated by eczema herpeticum in the disease group (ADEH+), and 50 patients under the age of 18 with atopic dermatitis without any episode of eczema herpeticum in the control group (ADEH-). We retrospectively reviewed the clinical features, treatment and prognosis of the 2 groups. Results: In this study, eczema herpeticum occurred in 2.7% of the AD patients. No significant difference in percentage of boys or mean age was found between the ADEH+ and ADEH- groups. In the ADEH+ group, eczema herpeticum occurred more frequently in the head and neck. Severe atopic dermatitis, recurrent impetigo, IgE-mediated atopic dermatitis and food allergy were identified as the risk factors of eczema herpeticum. The mean white blood cell count, erythrocyte sedimentation rate, percent of eosinophils and total serum IgE were higher in the ADEH+ group than in the ADEH- group. More than 2 recurrences were confirmed in 12 patients (26.7%). Conclusion: In the ADEH+ group, skin lesions were dominant on the head and neck. We revealed that severe atopic dermatitis, frequent impetigo, IgE-mediated atopic dermatitis, and food allergy are risk factors for eczema herpeticum.

Keywords

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