Allergy, Asthma & Respiratory Disease

  • 제6권3호
  • /
  • Pages.161-167
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  • 2018
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  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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비염을 가진 소아 및 청소년 환자에서 비호산구와 흡입항원 감작의 상관성

The association between nasal eosinophilia and aeroallergen sensitization in children and adolescents with rhinitis

  • 양은애 (가톨릭대학교 의과대학 소아과학교실) ;
  • 박유미 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김경훈 (가톨릭대학교 의과대학 소아과학교실) ;
  • 이혜진 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김환수 (가톨릭대학교 의과대학 소아과학교실) ;
  • 전윤홍 (가톨릭대학교 의과대학 소아과학교실) ;
  • 윤종서 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김현희 (가톨릭대학교 의과대학 소아과학교실) ;
  • 김진택 (가톨릭대학교 의과대학 소아과학교실)
  • Yang, Eun Ae (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Park, Yu Mi (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Kyung Hoon (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Lee, Hye Jin (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hwan Soo (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Chun, Yoon Hong (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Yoon, Jong-Seo (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hyun Hee (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Kim, Jin Tack (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
  • 투고 : 2017.09.08
  • 심사 : 2018.01.10
  • 발행 : 2018.05.31
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: To identify the correlation between nasal eosinophilia and aeroallergen sensitization in children and adolescents. Methods: This is a retrospective study of patients below 18 years of age who had a history of rhinitis that lasted more than 2 weeks or had been repeated more than once a year, received nasal eosinophil examinations, and had serum specific IgE to aeroallergens measured at an Allergy Clinic in a single tertiary teaching hospital in Seoul, Korea. The percentage of nasal eosinophils was calculated by the number of eosinophils per total leukocytes in a high-power field of $1,000{\times}$. Data was analyzed to determine the association between nasal eosinophilia and 18 aeroallergens. Results: Of the 245 patients included, 156 (63.7%) were male and the mean age (${\pm}$ standard deviation) was 7.9 years (${\pm}3.8$). In total, 175 patients (71.4%) were sensitized to at least 1 of the 18 aeroallergens tested, and sensitization to house dust mite was most common. In addition, 118 (48.2%) and 69 patients (28.2%) had nasal eosinophilia of at least 1% and 5%, respectively. There were no significant correlations between serum total IgE or age and the percentage of nasal eosinophils. However, the percentage of nasal eosinophils in the group sensitized to any aeroallergens was significantly increased compared to the nonsensitized group (P= 0.002). The percentage of nasal eosinophils was significantly higher in patients who were sensitized to Birch-Alder Mix, oak white, Bermuda grass, orchard grass, timothy grass, sweet vernal grass, rye, mugwort, short ragweed, Alternaria alternata, cats, dogs or Dermatophagoides farinae compared to those nonsensitized. Conclusion: Nasal eosinophilia was significantly associated with sensitization to aeroallergens.

키워드

참고문헌

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피인용 문헌

  1. 서금요법이 알레르기 비염 대학생의 비호산구, 비염증상, 비염관련 삶의 질에 미치는 효과 vol.22, pp.2, 2020, https://doi.org/10.7586/jkbns.2020.22.2.127