References
- Marshall PS, Mathews KS, Siegel MD. Diagnosis and management of life-threatening pulmonary embolism. J Intensive Care Med 2011;26:275-94. https://doi.org/10.1177/0885066610392658
- Heit JA. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol 2008;28:370-2. https://doi.org/10.1161/ATVBAHA.108.162545
- Cohen AT, Agnelli G, Anderson FA, et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost 2007;98:756-64. https://doi.org/10.1160/TH07-03-0212
- Eurostat: Eurostat statistics on health and safety 2001 [Internet]. Luxembourg: Eurostat; 2001. Available from: http://ec.europa.eu/eurostat/search?p_auth=2D3nmKEv&p_p_id=estatsearchportlet_WAR_estatsearchportlet&p_p_lifecycle=1&p_p_state=maximized&p_p_mode=view&_estatsearchportlet_WAR_estatsearchportlet_action=search&text=PULMONARY+EMBOLISM.
- Klok FA, van Kralingen KW, van Dijk AP, et al. Quality of life in long-term survivors of acute pulmonary embolism. Chest 2010;138:1432-40. https://doi.org/10.1378/chest.09-2482
- Fanikos J, Piazza G, Zayaruzny M, Goldhaber SZ. Long-term complications of medical patients with hospital-acquired venous thromboembolism. Thromb Haemost 2009;102:688-93.
- Stein PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest 1995;108:978-81. https://doi.org/10.1378/chest.108.4.978
- Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study. Arch Intern Med 1999;159:445-53. https://doi.org/10.1001/archinte.159.5.445
- Pichereau C, Maury E, Monnier-Cholley L, et al. Post-mortem CT scan with contrast injection and chest compression to diagnose pulmonary embolism. Intensive Care Med 2015;41:167-8. https://doi.org/10.1007/s00134-014-3520-4
- Opinions regarding the diagnosis and management of venous thromboembolic disease. ACCP Consensus Committee on Pulmonary Embolism. American College of Chest Physicians. Chest 1998;113:499-504. https://doi.org/10.1378/chest.113.2.499
- Laporte S, Mismetti P, Decousus H, et al. Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry. Circulation 2008;117:1711-6. https://doi.org/10.1161/CIRCULATIONAHA.107.726232
- Tzoran I, Brenner B, Papadakis M, Di Micco P, Monreal M. VTE registry: what can be learned from RIETE? Rambam Maimonides Med J 2014;5:e0037. https://doi.org/10.5041/RMMJ.10171
- Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 1999;353:1386-9. https://doi.org/10.1016/S0140-6736(98)07534-5
- Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 2000;160:809-15. https://doi.org/10.1001/archinte.160.6.809
- Pineda LA, Hathwar VS, Grant BJ. Clinical suspicion of fatal pulmonary embolism. Chest 2001;120:791-5. https://doi.org/10.1378/chest.120.3.791
- Babak S, Sriram KB. Misinterpreting risk and test results delays diagnosis in a patient with pulmonary embolism. BMJ Case Rep 2014;2014:bcr2014204172. https://doi.org/10.1136/bcr-2014-204172
- Cohen AT, Edmondson RA, Phillips MJ, et al. The changing pattern of venous thromboembolic disease. Haemostasis 1996;26:65-71.
- Sandler DA, Martin JF. Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? J R Soc Med 1989;82:203-5. https://doi.org/10.1177/014107688908200407
- Pollack CV, Schreiber D, Goldhaber SZ, et al. Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department: initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry). J Am Coll Cardiol 2011;57:700-6. https://doi.org/10.1016/j.jacc.2010.05.071
- Stein PD, Henry JW. Clinical characteristics of patients with acute pulmonary embolism stratified according to their presenting syndromes. Chest 1997;112:974-9. https://doi.org/10.1378/chest.112.4.974
- Thames MD, Alpert JS, Dalen JE. Syncope in patients with pulmonary embolism. JAMA 1977;238:2509-11. https://doi.org/10.1001/jama.1977.03280240055020
- Islam M, Filopei J, Frank M, et al. Pulmonary infarction secondary to pulmonary embolism: an evolving paradigm. Respirology. 2018 [Epub ahead of print].
- Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation 2011;123:1788-830. https://doi.org/10.1161/CIR.0b013e318214914f
- Adabag AS, Luepker RV, Roger VL, Gersh BJ. Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol 2010;7:216-25. https://doi.org/10.1038/nrcardio.2010.3
- Zipes DP, Wellens HJ. Sudden cardiac death. Circulation 1998;98:2334-51. https://doi.org/10.1161/01.CIR.98.21.2334
- Knight B. Forensic pathology. 2nd ed. London: Edward Arnold; 1996.
- Chugh SS. Sudden cardiac death with apparently normal heart: clinical implications of progress in pathophysiology. Card Electrophysiol Rev 2001;5:394-402. https://doi.org/10.1023/A:1013254132689
- Eckart RE, Shry EA, Burke AP, et al. Sudden death in young adults: an autopsy-based series of a population undergoing active surveillance. J Am Coll Cardiol 2011;58:1254-61. https://doi.org/10.1016/j.jacc.2011.01.049
- Lucena J, Rico A, Vazquez R, et al. Pulmonary embolism and sudden-unexpected death: prospective study on 2477 forensic autopsies performed at the Institute of Legal Medicine in Seville. J Forensic Leg Med 2009;16:196-201. https://doi.org/10.1016/j.jflm.2008.08.015
- Kurkciyan I, Meron G, Behringer W, et al. Accuracy and impact of presumed cause in patients with cardiac arrest. Circulation 1998;98:766-71. https://doi.org/10.1161/01.CIR.98.8.766
- Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous thromboembolism: a public health concern. Am J Prev Med 2010;38:S495-501. https://doi.org/10.1016/j.amepre.2009.12.017
- Heit JA. The epidemiology of venous thromboembolism in the community: implications for prevention and management. J Thromb Thrombolysis 2006;21:23-9. https://doi.org/10.1007/s11239-006-5572-y
- Patriquin L, Khorasani R, Polak JF. Correlation of diagnostic imaging and subsequent autopsy findings in patients with pulmonary embolism. AJR Am J Roentgenol 1998;171:347-9. https://doi.org/10.2214/ajr.171.2.9694449
- Bharadwaj RS, Slade TB. Diagnosis of pulmonary thromboembolism in psychiatric patients. Prim Care Companion CNS Disord 2011;13:PCC.10l01076.
- Bougouin W, Marijon E, Planquette B, et al. Factors associated with pulmonary embolism-related sudden cardiac arrest. Circulation 2016;134:2125-7. https://doi.org/10.1161/CIRCULATIONAHA.116.024746
- Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation 2012;125:e2-220. https://doi.org/10.1161/CIR.0b013e31823ac046
- Rodger MA, Carrier M, Jones GN, et al. Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism. Am J Respir Crit Care Med 2000;162:2105-8. https://doi.org/10.1164/ajrccm.162.6.2004204
- Stein PD, Goldhaber SZ, Henry JW, Miller AC. Arterial blood gas analysis in the assessment of suspected acute pulmonary embolism. Chest 1996;109:78-81. https://doi.org/10.1378/chest.109.1.78
- Geibel A, Zehender M, Kasper W, et al. Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. Eur Respir J 2005;25:843-8. https://doi.org/10.1183/09031936.05.00119704
- Page IH. Serotonin (5-hydroxytryptamine); the last four years. Physiol Rev 1958;38:277-335. https://doi.org/10.1152/physrev.1958.38.2.277
- Lewis GP. Active polypeptides derived from plasma proteins. Physiol Rev 1960;40:647-76. https://doi.org/10.1152/physrev.1960.40.4.647
- Boyer NH, Curry JJ. Bronchospasm associated with pulmonary embolism. Arch Intern Med (Chic) 1944;73:403-9. https://doi.org/10.1001/archinte.1944.00210170040006
- Xu K, Tang X, Song Y, Chen Z. The diagnostic dilemma between pulmonary embolism with positive chest imaging and pneumonia: a case report and literature review. J Transl Med Epidemiol 2015;3:1039.
- Karabulut N, Kiroglu Y. Relationship of parenchymal and pleural abnormalities with acute pulmonary embolism: CT findings in patients with and without embolism. Diagn Interv Radiol 2008;14:189-96.
- Duru S, Kelesoglu A, Ardic S. Clinical update on pulmonary embolism. Arch Med Sci 2014;10:557-65.
- Konstantinides S. Pulmonary embolism: impact of right ventricular dysfunction. Curr Opin Cardiol 2005;20:496-501. https://doi.org/10.1097/01.hco.0000179818.65329.bb
- Fonarow GC, Abraham WT, Albert NM, et al. Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med 2008;168:847-54. https://doi.org/10.1001/archinte.168.8.847
- McMichael J. Pulmonary heart disease acute and chronic. Br Heart J 1948;10:80-7. https://doi.org/10.1136/hrt.10.2.80
- McIntyre KM, Sasahara AA. The hemodynamic response to pulmonary embolism in patients without prior cardiopulmonary disease. Am J Cardiol 1971;28:288-94. https://doi.org/10.1016/0002-9149(71)90116-0
- Wolfe MW, Lee RT, Feldstein ML. Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary embolism. Am Heart J 1994;127:1371-5. https://doi.org/10.1016/0002-8703(94)90058-2
- McConnell MV, Solomon SD, Rayan ME, et al. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol 1996;78:469-73. https://doi.org/10.1016/S0002-9149(96)00339-6
- Wood KE. Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 2002;121:877-905. https://doi.org/10.1378/chest.121.3.877
- Luisada AA, Cardi L. Acute pulmonary edema; pathology, physiology and clinical management. Circulation 1956;13:113-35. https://doi.org/10.1161/01.CIR.13.1.113
- Harjola VP, Mebazaa A, Celutkiene J, et al. Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 2016;18:226-41. https://doi.org/10.1002/ejhf.478
- Wolff L. Pulmonary embolism. Circulation 1952;6:768-76. https://doi.org/10.1161/01.CIR.6.5.768
- ESC Committee for Practice guidelines (CPG), Konstantinides SV, Torbicki A, et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2014;35:3033-73. https://doi.org/10.1093/eurheartj/ehu283
- Amini R, Jyothidasan A, Poommipanit P, Kapoor D. EKG findings mimicking left main coronary disease in a patient with acute massive pulmonary embolism. J Am Coll Cardiol 2014;63 suppl:A699. https://doi.org/10.1016/S0735-1097(14)60699-9
- Manne JR. Acute ST segment elevation in a patient with massive pulmonary embolism mimicking acute left main coronary artery obstruction. J Am Coll Cardiol 2016;67:1118.
- Ciliberti P, Rapezzi C, Villani C, Boriani G. Massive pulmonary embolism with acute coronary syndrome-like electrocardiogram mimicking acute left main coronary artery obstruction. J Emerg Med 2012;43:e255-8. https://doi.org/10.1016/j.jemermed.2011.03.037
- Kosuge M, Ebina T, Hibi K, et al. Simple electrocardiographic criteria for discriminating between acute pulmonary embolism and acute coronary syndrome. J Am Coll Cardiol 2016;67:528. https://doi.org/10.1016/S0735-1097(16)30529-0
- Kosuge M, Ebina T, Hibi K, et al. Differences in negative T waves among acute coronary syndrome, acute pulmonary embolism, and Takotsubo cardiomyopathy. Eur Heart J Acute Cardiovasc Care 2012;1:349-57. https://doi.org/10.1177/2048872612466790
- Yameogo NV, Mbaye A, Kagambega LJ, et al. Pulmonary embolism mimicking acute anterior myocardial infarction: diagnostic trap. Ann Cardiol Angeiol (Paris) 2011;60:169-72. https://doi.org/10.1016/j.ancard.2010.12.011
- Falterman TJ, Martinez JA, Daberkow D, Weiss LD. Pulmonary embolism with ST segment elevation in leads V1 to V4: case report and review of the literature regarding electrocardiographic changes in acute pulmonary embolism. J Emerg Med 2001;21:255-61. https://doi.org/10.1016/S0736-4679(01)00381-X
- Omar HR. ST-segment elevation in V1-V4 in acute pulmonary embolism: a case presentation and review of literature. Eur Heart J Acute Cardiovasc Care 2016;5:579-86. https://doi.org/10.1177/2048872615604273
- Mittal SR, Maheshwari M. Electrocardiographic changes in submassive pulmonary embolism. Indian Heart J 2005;57:80-1.
- Duplyakov D, Kurakina E, Pavlova T, et al. Value of syncope in patients with high-to-intermediate risk pulmonary artery embolism. Eur Heart J Acute Cardiovasc Care 2015;4:353-8. https://doi.org/10.1177/2048872614527837
- Jenab Y, Lotfi-Tokaldany M, Alemzadeh-Ansari MJ, et al. Correlates of syncope in patients with acute pulmonary thromboembolism. Clin Appl Thromb Hemost 2015;21:772-6. https://doi.org/10.1177/1076029614540037
- Yamaki T, Nozaki M, Sakurai H, et al. Presence of lower limb deep venous thrombosis and prognosis in patients with symptomatic pulmonary embolism: preliminary report. Eur J Vasc Endovasc Surg 2009;37:225-31. https://doi.org/10.1016/j.ejvs.2008.08.018
- Jimenez D, Aujesky D, Diaz G, et al. Prognostic significance of deep vein thrombosis in patients presenting with acute symptomatic pulmonary embolism. Am J Respir Crit Care Med 2010;181:983-91. https://doi.org/10.1164/rccm.200908-1204OC
- Lin JF, Li YC, Yang PL. A case of massive pulmonary embolism with ST elevation in leads V1-4. Circ J 2009;73:1157-9. https://doi.org/10.1253/circj.CJ-08-0474
- Mittal SR, Arora H. Pulmonary embolism with isolated right ventricular infarction. Indian Heart J 2001;53:218-20.
- Mittal SR, Jain S, Maheshwari S. Pulmonary embolism with isolated right ventricular infarction. Indian Heart J 1996;48:704-6.
- Jerjes Sanchez C, Gutierrez-Fajardo P, Ramirez-Rivera A, et al. Acute infarct of the right ventricle secondary to a massive pulmonary thromboembolism. Arch Inst Cardiol Mex 1995;65:65-73.
- Olivares-Reyes A, Chan S, Lazar EJ, Bandlamudi K, Narla V, Ong K. Atrial septal aneurysm: a new classification in two hundred five adults. J Am Soc Echocardiogr 1997;10:644-56. https://doi.org/10.1016/S0894-7317(97)70027-0
- Kleber FX, Hauschild T, Schulz A. Paradoxical embolic myocardial infarction. J Am Coll Cardiol 2014;64:TCT-163.
- Wasek WC, Samul W, Ryczek R, Skrobowski A. Unique case of ST-segment-elevation myocardial infarction related to paradoxical embolization and simultaneous pulmonary embolization: clinical considerations on indications for patent foramen ovale closure in no-guidelines land. Circulation 2015;131:1214-23. https://doi.org/10.1161/CIRCULATIONAHA.114.009846
- Yildiz A, Bostan C, Akin F, Arat Ozkan A, Gurmen T. Concurrent pulmonary embolism and acute coronary syndrome with dynamic electrocardiographic changes. Am J Emerg Med 2012;30:637.e1-637.e4.
- Windecker S, Stortecky S, Meier B. Paradoxical embolism. J Am Coll Cardiol 2014;64:403-15. https://doi.org/10.1016/j.jacc.2014.04.063
- Carey HB, Boltax R, Dickey KW, Finkelstein FO. Bilateral renal infarction secondary to paradoxical embolism. Am J Kidney Dis 1999;34:752-5. https://doi.org/10.1016/S0272-6386(99)70403-8
- Vicente DC, Kazmers A. Acute mesenteric ischemia. Curr Opin Cardiol 1999;14:453-8. https://doi.org/10.1097/00001573-199909000-00016
- Loscalzo J. Paradoxical embolism: clinical presentation, diagnostic strategies, and therapeutic options. Am Heart J 1986;112:141-5. https://doi.org/10.1016/0002-8703(86)90692-7
- Wei F, Zhang Y, Tian H, Zhang J, Ma Q. Pulmonary hypertension and massive or sub-massive pulmonary embolism are the high risk factors for paradoxical peripheral arterial embolism. J Am Coll Cardiol 2016;68:C154.
- Akrawinthawong K, Damrongwatanasuk R, Abuzahra M. Acute limb ischemia and silent pulmonary emboli as a key to identify thrombus-in-transit through patent foramen ovale. J Am Coll Cardiol 2016;67:1194. https://doi.org/10.1016/S0735-1097(16)31195-0
- Konstantinides S, Geibel A, Kasper W, Olschewski M, Blumel L, Just H. Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism. Circulation 1998;97:1946-51. https://doi.org/10.1161/01.CIR.97.19.1946
- Di Tullio M, Sacco RL, Venketasubramanian N, Sherman D, Mohr JP, Homma S. Comparison of diagnostic techniques for the detection of a patent foramen ovale in stroke patients. Stroke 1993;24:1020-4. https://doi.org/10.1161/01.STR.24.7.1020
- Pinto FJ. When and how to diagnose patent foramen ovale. Heart 2005;91:438-40. https://doi.org/10.1136/hrt.2004.052233
- Prandoni P, Lensing AW, Prins MH, et al. Prevalence of pulmonary embolism among patients hospitalized for syncope. N Engl J Med 2016;375:1524-31. https://doi.org/10.1056/NEJMoa1602172
- Kearon C. Natural history of venous thromboembolism. Circulation 2003;107:I22-30.
- Varkul M, Robinson T, Ng E, Hyland R. Orthodeoxia and platypnea secondary to a patent foramen ovale despite normal right-sided cardiac pressures. Can Respir J 2001;8:105-7. https://doi.org/10.1155/2001/319027
- Sentjens RE, Houtman S, Meijerink MR, Konings TC. Emboli on the move. J Crit Care 2010;14:399-401. https://doi.org/10.1186/cc8631
- Giorgi-Pierfranceschi M, Cattabiani C, Mumoli N, Dentali F. Abdominal pain as pulmonary embolism presentation, usefulness of bedside ultrasound: a report of two cases. Blood Coagul Fibrinolysis 2017;28:107-111. https://doi.org/10.1097/MBC.0000000000000542
- Inouye SK. Delirium in older persons. N Engl J Med 2006;354:1157-65. https://doi.org/10.1056/NEJMra052321
- Laack TA, Goyal DG. Pulmonary embolism: an unsuspected killer. Emerg Med Clin North Am 2004;22:961-83. https://doi.org/10.1016/j.emc.2004.05.011
- Sogaard KK, Schmidt M, Pedersen L, Horvath-Puho E, Sorensen HT. 30-year mortality after venous thromboembolism: a population-based cohort study. Circulation 2014;130:829-36. https://doi.org/10.1161/CIRCULATIONAHA.114.009107
- Carrascosa MF, Batan AM, Novo MF. Delirium and pulmonary embolism in the elderly. Mayo Clin Proc 2009;84:91-2. https://doi.org/10.4065/84.1.91
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