Clinical and Experimental Vaccine Research

  • 제7권1호
  • /
  • Pages.43-50
  • /
  • 2018
  • /
  • 2287-3651(pISSN)
  • /
  • 2287-366X(eISSN)
대한백신학회 (The Korean Vaccine Society)
권호 표지
DOI QR코드

DOI QR Code

Epidemiology of severe fever and thrombocytopenia syndrome virus infection and the need for therapeutics for the prevention

  • Robles, Norbert John C. (Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Han, Hae Jung (Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Park, Su-Jin (Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Choi, Young Ki (Department of Microbiology, College of Medicine and Medical Research Institute, Chungbuk National University)
  • 투고 : 2017.12.30
  • 심사 : 2018.01.13
  • 발행 : 2018.01.31
⟨ 이전 논문 다음 논문 ⟩

초록

Over the past ten years there has been a marked increase in cases of severe fever and thrombocytopenia syndrome in East Asia. This tick-borne hemorrhagic fever presents along with clinical signs including high fever and leukopenia. In addition to humans, the virus has also been detected with shared genetic homology in farm animals including goats, cattle, horses, and pigs. Furthermore, several genotypes of severe fever and thrombocytopenia syndrome virus (SFTSV) are currently co-circulating between humans and animals. In China, where the virus was first detected in rural areas in 2009, the SFTSV mortality rate has been reported to be as 6% and higher than 30%, especially in immuno-compromised patients. Moreover, this virus has been isolated in neighbor countries including Japan and South Korea where the fatality rates in 2015 were more than 30% in both countries. In this review, we comprehensively summarize the virology, genotypes, pathogenesis, and epidemiology of SFTSV infection in humans and animals. Currently, a collaborative global approach against SFTSV infection is being undertaken; however, the need for continuous disease surveillance and production of an effective vaccine is imperative as this virus may lead to an epidemic of irreversible status in both humans and animals.

키워드

과제정보

연구 과제 주관 기관 : Korea Health Industry Development Institute

참고문헌

  1. Yu XJ, Liang MF, Zhang SY, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 2011;364:1523-32. https://doi.org/10.1056/NEJMoa1010095
  2. Xiong WY, Feng ZJ, Matsui T, Foxwell AR. Risk assessment of human infection with a novel bunyavirus in China. Western Pac Surveill Response J 2012;3:61-6. https://doi.org/10.5365/wpsar.2012.3.3.004
  3. Elliott RM. Bunyaviruses and climate change. Clin Microbiol Infect 2009;15:510-7. https://doi.org/10.1111/j.1469-0691.2009.02849.x
  4. Mayo MA. Virus taxonomy: Houston 2002. Arch Virol 2002;147:1071-6. https://doi.org/10.1007/s007050200036
  5. Pepin M, Bouloy M, Bird BH, Kemp A, Paweska J. Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet Res 2010;41:61. https://doi.org/10.1051/vetres/2010033
  6. Li DX. Fever with thrombocytopenia associated with a novel bunyavirus in China. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2011;25:81-4.
  7. Ding S, Yin H, Xu X, et al. A cross-sectional survey of severe fever with thrombocytopenia syndrome virus infection of domestic animals in Laizhou City, Shandong Province, China. Jpn J Infect Dis 2014;67:1-4. https://doi.org/10.7883/yoken.67.1
  8. Ohagi Y, Tamura S, Nakamoto C, et al. Mild clinical course of severe fever with thrombocytopenia syndrome virus infection in an elderly Japanese patient. Case Rep Infect Dis 2014;2014:918135.
  9. Denic S, Janbeih J, Nair S, Conca W, Tariq WU, Al-Salam S. Acute thrombocytopenia, leucopenia, and multiorgan dysfunction: the first case of SFTS Bunyavirus outside China? Case Rep Infect Dis 2011;2011:204056.
  10. Charrel RN, Moureau G, Temmam S, et al. Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. Vector Borne Zoonotic Dis 2009;9:519-30. https://doi.org/10.1089/vbz.2008.0131
  11. Anagnostou V, Pardalos G, Athanasiou-Metaxa M, Papa A. Novel phlebovirus in febrile child, Greece. Emerg Infect Dis 2011;17:940-1. https://doi.org/10.3201/eid1705.101958
  12. McMullan LK, Folk SM, Kelly AJ, et al. A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med 2012;367:834-41. https://doi.org/10.1056/NEJMoa1203378
  13. Xu B, Liu L, Huang X, et al. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog 2011;7:e1002369. https://doi.org/10.1371/journal.ppat.1002369
  14. Takahashi T, Maeda K, Suzuki T, et al. The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan. J Infect Dis 2014;209: 816-27. https://doi.org/10.1093/infdis/jit603
  15. Kim KH, Yi J, Kim G, et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 2013; 19:1892-4.
  16. Zhan J, Wang Q, Cheng J, et al. Current status of severe fever with thrombocytopenia syndrome in China. Virol Sin 2017;32:51-62. https://doi.org/10.1007/s12250-016-3931-1
  17. Saito T, Fukushima K, Umeki K, Nakajima K. Severe fever with thrombocytopenia syndrome in Japan and public health communication. Emerg Infect Dis 2015;21:487-9. https://doi.org/10.3201/eid2103.140831
  18. Chang MS, Woo JH. Severe fever with thrombocytopenia syndrome: tick-mediated viral disease. J Korean Med Sci 2013;28:795-6. https://doi.org/10.3346/jkms.2013.28.6.795
  19. Yoo SJ, Heo ST, Lee KH. Severe fever with thrombocytopenia syndrome. Korean J Crit Care Med 2014;29:59-63. https://doi.org/10.4266/kjccm.2014.29.2.59
  20. Zhang YZ, Zhou DJ, Qin XC, et al. The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China. J Virol 2012;86:2864-8. https://doi.org/10.1128/JVI.06192-11
  21. Ding F, Zhang W, Wang L, et al. Epidemiologic features of severe fever with thrombocytopenia syndrome in China, 2011-2012. Clin Infect Dis 2013;56:1682-3. https://doi.org/10.1093/cid/cit100
  22. Heath AC. Vector competence of Haemaphysalis longicornis with particular reference to blood parasites. Surveillance 2002;29:12-4.
  23. Ding F, Guan XH, Kang K, et al. Risk factors for bunyavirus-associated severe Fever with thrombocytopenia syndrome, China. PLoS Negl Trop Dis 2014;8:e3267. https://doi.org/10.1371/journal.pntd.0003267
  24. Zhao L, Zhai S, Wen H, et al. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis 2012;18:963-5.
  25. Chen H, Hu K, Zou J, Xiao J. A cluster of cases of humanto-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis 2013; 17:e206-8. https://doi.org/10.1016/j.ijid.2012.11.006
  26. Liu Y, Li Q, Hu W, et al. Person-to-person transmission of severe fever with thrombocytopenia syndrome virus. Vector Borne Zoonotic Dis 2012;12:156-60. https://doi.org/10.1089/vbz.2011.0758
  27. Fu Y, Li S, Zhang Z, et al. Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean. Sci Rep 2016;6:19563. https://doi.org/10.1038/srep19563
  28. Shi J, Hu S, Liu X, et al. Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus. Infect Genet Evol 2017;47:109-17. https://doi.org/10.1016/j.meegid.2016.11.015
  29. Niu G, Li J, Liang M, et al. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 2013;19:756-63.
  30. Li Z, Hu J, Bao C, et al. Seroprevalence of antibodies against SFTS virus infection in farmers and animals, Jiangsu, China. J Clin Virol 2014;60:185-9. https://doi.org/10.1016/j.jcv.2014.03.020
  31. Jiao Y, Qi X, Liu D, et al. Experimental and natural infections of goats with severe fever with thrombocytopenia syndrome virus: evidence for ticks as viral vector. PLoS Negl Trop Dis 2015;9:e0004092. https://doi.org/10.1371/journal.pntd.0004092
  32. Li Z, Bao C, Hu J, et al. Ecology of the tick-borne phlebovirus causing severe fever with thrombocytopenia syndrome in an endemic area of China. PLoS Negl Trop Dis 2016;10: e0004574. https://doi.org/10.1371/journal.pntd.0004574
  33. Tabara K, Fujita H, Hirata A, Hayasaka D. Investigation of severe fever with thrombocytopenia syndrome virus antibody among domestic bovines transported to slaughterhouse in Shimane Prefecture, Japan. Jpn J Infect Dis 2016; 69:445-7. https://doi.org/10.7883/yoken.JJID.2015.624
  34. Liu Q, He B, Huang SY, Wei F, Zhu XQ. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis 2014;14:763-72. https://doi.org/10.1016/S1473-3099(14)70718-2
  35. Lee SH, Kim HJ, Byun JW, et al. Molecular detection and phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in shelter dogs and cats in the Republic of Korea. Ticks Tick Borne Dis 2017;8:626-30. https://doi.org/10.1016/j.ttbdis.2017.04.008
  36. Japanese woman dies from tick disease after cat bite [Internet]. London: BBC News; 2017 [cited 2017 Dec 30]. Available from: http://www.bbc.com/news/world-asia-40713172.
  37. Oh SS, Chae JB, Kang JG, et al. Detection of severe fever with thrombocytopenia syndrome virus from wild animals and ixodidae ticks in the Republic of Korea. Vector Borne Zoonotic Dis 2016;16:408-14. https://doi.org/10.1089/vbz.2015.1848
  38. Hayasaka D, Fuxun Y, Yoshikawa A, et al. Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan. Trop Med Health 2016;44:6. https://doi.org/10.1186/s41182-016-0009-6
  39. Li S, Xue C, Fu Y, et al. Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China. Biosci Trends 2011;5:273-6. https://doi.org/10.5582/bst.2011.v5.6.273
  40. Liu S, Chai C, Wang C, et al. Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics. Rev Med Virol 2014;24:90-102. https://doi.org/10.1002/rmv.1776
  41. Ni H, Yang F, Li Y, et al. Apodemus agrarius is a potential natural host of severe fever with thrombocytopenia syndrome (SFTS)-causing novel bunyavirus. J Clin Virol 2015; 71:82-8. https://doi.org/10.1016/j.jcv.2015.08.006
  42. Lu YN, Dou XF, Wang XM, et al. Preliminary investigation on the carriage status of the novel bunyavirus among animals and ticks in Beijing area. Int J Virol 2011;18:33-6.
  43. Reed KD, Meece JK, Henkel JS, Shukla SK. Birds, migration and emerging zoonoses: west nile virus, lyme disease, influenza A and enteropathogens. Clin Med Res 2003;1:5-12. https://doi.org/10.3121/cmr.1.1.5
  44. Lee KH, Medlock JM, Heo ST. Severe fever with thrombocytopenia syndrome virus, Crimean-Congo haemorrhagic fever virus, and migratory birds. J Bacteriol Virol 2013;43:235-43. https://doi.org/10.4167/jbv.2013.43.4.235
  45. Yun Y, Heo ST, Kim G, et al. Phylogenetic analysis of severe fever with thrombocytopenia syndrome virus in South Korea and migratory bird routes Between China, South Korea, and Japan. Am J Trop Med Hyg 2015;93:468-74. https://doi.org/10.4269/ajtmh.15-0047
  46. Choi CY, Kang CW, Kim EM, et al. Ticks collected from migratory birds, including a new record of Haemaphysalis formosensis, on Jeju Island, Korea. Exp Appl Acarol 2014; 62:557-66. https://doi.org/10.1007/s10493-013-9748-9
  47. Yoo JR, Heo ST, Park D, et al. Family cluster analysis of severe fever with thrombocytopenia syndrome virus infection in Korea. Am J Trop Med Hyg 2016;95:1351-7. https://doi.org/10.4269/ajtmh.16-0527
  48. Oh WS, Heo ST, Kim SH, Choi WJ, Han MG, Kim JY. Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome. Int J Infect Dis 2014;18:84-6. https://doi.org/10.1016/j.ijid.2013.08.011
  49. Jia Z, Wu X, Wang L, et al. Identification of a candidate standard strain of severe fever with thrombocytopenia syndrome virus for vaccine quality control in China using a cross-neutralization assay. Biologicals 2017;46:92-8. https://doi.org/10.1016/j.biologicals.2017.01.005
  50. Liu Y, Wu B, Paessler S, Walker DH, Tesh RB, Yu XJ. The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: insights into the pathologic mechanisms of a new viral hemorrhagic fever. J Virol 2014;88:1781-6. https://doi.org/10.1128/JVI.02277-13
  51. Tani H, Fukuma A, Fukushi S, et al. Efficacy of T-705 (Favipiravir) in the treatment of infections with lethal severe fever with thrombocytopenia syndrome virus. mSphere 2016;1:e00061-15.
  52. Chen XP, Cong ML, Li MH, et al. Infection and pathogenesis of Huaiyangshan virus (a novel tick-borne bunyavirus) in laboratory rodents. J Gen Virol 2012;93:1288-93. https://doi.org/10.1099/vir.0.041053-0
  53. Jin C, Liang M, Ning J, et al. Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/ BL6 mouse model. Proc Natl Acad Sci U S A 2012;109:10053-8. https://doi.org/10.1073/pnas.1120246109
  54. Jin C, Jiang H, Liang M, et al. SFTS virus infection in nonhuman primates. J Infect Dis 2015;211:915-25. https://doi.org/10.1093/infdis/jiu564

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  5. Epidemiological and Clinical Characteristics of Confirmed Cases of Severe Fever With Thrombocytopenia Syndrome in Jeju Province, Korea, 2014-2018 vol.52, pp.3, 2018, https://doi.org/10.3961/jpmph.18.289
  6. The Ecology of New Constituents of the Tick Virome and Their Relevance to Public Health vol.11, pp.6, 2019, https://doi.org/10.3390/v11060529
  7. Susceptibility of spotted doves (Streptopelia chinensis) to experimental infection with the severe fever with thrombocytopenia syndrome phlebovirus vol.13, pp.7, 2018, https://doi.org/10.1371/journal.pntd.0006982
  8. Development of magnetic attraction systems to mark and recapture a medically important vector, Haemaphysalis longicornis (Acari: Ixodidae) vol.54, pp.3, 2018, https://doi.org/10.1007/s13355-019-00620-6
  9. Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea vol.57, pp.10, 2019, https://doi.org/10.1007/s12275-019-9174-8
  10. Severe fever and thrombocytopenia syndrome virus infection: Considerations for vaccine evaluation of a rare disease vol.15, pp.10, 2019, https://doi.org/10.1080/21645515.2019.1633875
  11. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Phlebovirus in Domesticated Deer in South Korea vol.34, pp.5, 2018, https://doi.org/10.1007/s12250-019-00137-w
  12. Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets vol.10, pp.1, 2018, https://doi.org/10.1038/s41467-019-11815-4
  13. Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice vol.8, pp.4, 2018, https://doi.org/10.3390/pathogens8040158
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  15. Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model vol.116, pp.52, 2019, https://doi.org/10.1073/pnas.1914704116
  16. Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea vol.5, pp.2, 2018, https://doi.org/10.1172/jci.insight.129531
  17. A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo vol.5, pp.13, 2018, https://doi.org/10.1172/jci.insight.136855
  18. Tick‐borne viruses: Current trends in large‐scale viral surveillance vol.50, pp.8, 2020, https://doi.org/10.1111/1748-5967.12435
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  20. Effects of steroid therapy in patients with severe fever with Thrombocytopenia syndrome: A multicenter clinical cohort study vol.15, pp.2, 2018, https://doi.org/10.1371/journal.pntd.0009128
  21. Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan vol.27, pp.4, 2018, https://doi.org/10.3201/eid2704.204148
  22. Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy vol.53, pp.5, 2021, https://doi.org/10.1038/s12276-021-00610-1
  23. Clinical Update of Severe Fever with Thrombocytopenia Syndrome vol.13, pp.7, 2021, https://doi.org/10.3390/v13071213
  24. Subcellular localization of nucleocapsid protein of SFTSV and its assembly into the ribonucleoprotein complex with L protein and viral RNA vol.11, pp.1, 2018, https://doi.org/10.1038/s41598-021-01985-x