Neonatal Medicine

The Korean Society of Neonatology (대한신생아학회)
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Clinical Implication of Surgically treated Abdominoperineal Soild Tumor in the Newborn : A Single-Center Experience

  • Cho, Yong-Hoon (Division of Pediatric Surgery, Department of Surgery, Pusan National University School of Medicine) ;
  • Kim, Soo-Hong (Division of Pediatric Surgery, Department of Surgery, Pusan National University School of Medicine) ;
  • Kim, Hae-Young (Division of Pediatric Surgery, Department of Surgery, Pusan National University School of Medicine) ;
  • Han, Young-Mi (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Lee, Na-Rae (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Bae, Mi-Hye (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Park, Kyung-Hee (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Byun, Shin-Yun (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine)
  • Received : 2017.09.11
  • Accepted : 2017.12.27
  • Published : 2018.02.28
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Abstract

Purpose: Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms. Methods: We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (${\leq}28$ days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection. Results: The mean gestational age and postnatal age at the time of operation were $38.3{\pm}1.8weeks$ and $13.5{\pm}8.3days$, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was $6.4{\times}5.3cm$ (3.5-17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean $66.4{\pm}44.2months$). Conclusion: Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.

Keywords

References

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