Sleep Medicine and Psychophysiology (수면정신생리)

KOREAN ACADEMY OF SLEEP MEDICINE (대한수면의학회)
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Comparison of Spatial Neurocognitive Function between Insomnia Disorder Patients and Normal Sleeping Control : Pilot Study

불면장애 환자와 정상대조군간의 공간인지기능 비교 : 예비연구

  • Kang, Suk-Ho (Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine) ;
  • Kang, Jae Myeong (Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine) ;
  • Na, Kyoung-Sae (Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine) ;
  • Koh, Seung-Hee (Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine) ;
  • Cho, Seong-Jin (Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine) ;
  • Kang, Seung-Gul (Department of Psychiatry, Gil Medical Center, Gachon University, College of Medicine)
  • 강석호 (가천대학교 의과대학 길병원 정신건강의학교실) ;
  • 강재명 (가천대학교 의과대학 길병원 정신건강의학교실) ;
  • 나경세 (가천대학교 의과대학 길병원 정신건강의학교실) ;
  • 고승희 (가천대학교 의과대학 길병원 정신건강의학교실) ;
  • 조성진 (가천대학교 의과대학 길병원 정신건강의학교실) ;
  • 강승걸 (가천대학교 의과대학 길병원 정신건강의학교실)
  • Received : 2018.03.05
  • Accepted : 2018.04.22
  • Published : 2018.06.30
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Abstract

Objectives: Chronic insomnia disorder is a common and one of the most distressing sleep disorders. This pilot study was conducted to compare the spatial function between insomnia disorder patients and good sleeping control. Methods: We enrolled the 22 patients with chronic insomnia during over one year who met the DSM-5 diagnostic criteria of insomnia disorder and 27 normal sleeping controls. The Cambridge Neuropsychological Test Automated Battery (CANTAB) has been performed to compare the spatial cognitive function between insomnia disorder patients and good sleeping controls. Results: The CANTAB results showed significant differences in the problems solved in minimum moves of Stockings of Cambridge test (t = -2.499, p = 0.017). The significant difference between two groups remained after controlling age, sex, and Beck Depression Index non-sleep scores (F = 5.631, p = 0.022). Conclusion: This study suggests that the patients with insomnia disorder have poor spatial planning function.

연구목적 : 만성불면증은 흔하고 가장 환자들을 괴롭히는 수면장애들 중 하나이다. 본 예비연구는 불면장애 환자들과 수면을 잘 취하는 건강인 간에 공간인지기능을 비교하기 위해 수행되었다. 연구대상 및 방법 : DSM-5상 불면장애의 진단기준을 만족하는 22명의 만성 불면장애 환자와 27명의 수면을 잘 취하는 정상대조군이 연구에 참여하였다. 전산화신경인지기능검사인 Cambridge Neuropsychological Test Automated Battery (CANTAB)를 시행하여 불면장애 환자와 정상대조군 간에 공간인지기능(spatial planning function)을 비교하였다. 결 과 : CANTAB 결과 상 Stockings of Cambridge test에서 더 저조한 problems solved in minimum moves 결과를 보였다(t = -2.499, p = 0.017) 이 항목은 나이, 성별, beck depression index 비수면점수를 통제한 ANCOVA 분석에서도 유의한 결과를 보였다(F = 5.631, p = 0.017)의 유의한 차이가 관찰되었다. 결 론 : 본 연구의 결과는 불면장애 환자들의 저조한 공간계획기능을 시사한다.

Keywords

References

  1. Ahmad S, Bashir S. A pilot study investigating the association between sleep and cognitive function among adolescents. Asian J Psychiatr 2017;28:34-37. https://doi.org/10.1016/j.ajp.2017.03.020
  2. Berry R, Gamaldo C, Harding S, Lloyd R, Marcus C, Vaughn B. The AASM manual for the scoring of sleep and associated events. Rules, terminology and technical specifications, scoring manual 2. 0. 2. American Academy of Sleep Medicine 2013.
  3. Cipolli C, Mazzetti M, Plazzi G. Sleep-dependent memory consolidation in patients with sleep disorders. Sleep Med Rev 2013;17:91-103. https://doi.org/10.1016/j.smrv.2012.01.004
  4. de Bruin EJ, van Run C, Staaks J, Meijer AM. Effects of sleep manipulation on cognitive functioning of adolescents: A systematic review. Sleep Med Rev 2017;32:45-57. https://doi.org/10.1016/j.smrv.2016.02.006
  5. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41:1149-1160. https://doi.org/10.3758/BRM.41.4.1149
  6. Fernandez-Mendoza J, Calhoun S, Bixler EO, Pejovic S, Karataraki M, Liao D, et al. Insomnia with objective short sleep duration is associated with deficits in neuropsychological performance: a general population study. Sleep 2010;33:459-465. https://doi.org/10.1093/sleep/33.4.459
  7. Fernandez-Mendoza J, Calhoun SL, Bixler EO, Karataraki M, Liao D, Vela-Bueno A, et al. Sleep misperception and chronic insomnia in the general population: role of objective sleep duration and psychological profiles. Psychosom Med 2011;73:88-97. https://doi.org/10.1097/PSY.0b013e3181fe365a
  8. Ferrara M, Iaria G, Tempesta D, Curcio G, Moroni F, Marzano C, et al. Sleep to find your way: the role of sleep in the consolidation of memory for navigation in humans. Hippocampus 2008;18:844-851. https://doi.org/10.1002/hipo.20444
  9. Fortier-Brochu E, Beaulieu-Bonneau S, Ivers H, Morin CM. Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev 2012;16:83-94. https://doi.org/10.1016/j.smrv.2011.03.008
  10. Kuzmickiene J, Kaubrys G. Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease. Medical Science Monitor 2015;21:3887-3899. https://doi.org/10.12659/MSM.896327
  11. Leger D, Guilleminault C, Bader G, Levy E, Paillard M. Medical and socio-professional impact of insomnia. Sleep 2002;25:625-629.
  12. Lin SW, Chou YT, Kao KC, Chuang LP, Yang CM, Hu HC, et al. Immediate and long-term neurocognitive outcome in patients with obstructive sleep apnea syndrome after continuous positive airway pressure treatment. Indian J Otolaryngol Head Neck Surg 2015;67(Suppl 1):79-85. https://doi.org/10.1007/s12070-014-0777-4
  13. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Medicine Reviews 2002;6:97-111. https://doi.org/10.1053/smrv.2002.0186
  14. Ohayon MM, Reynolds CF 3rd. Epidemiological and clinical relevance of insomnia diagnosis algorithms according to the DSMIV and the International Classification of Sleep Disorders (ICSD). Sleep Med 2009;10:952-960. https://doi.org/10.1016/j.sleep.2009.07.008
  15. Stickgold R, Walker MP. Sleep-dependent memory consolidation and reconsolidation. Sleep Med 2007;8:331-343. https://doi.org/10.1016/j.sleep.2007.03.011
  16. Stuchlik A, Kubik S, Vlcek K, Vales K. Spatial navigation: implications for animal models, drug development and human studies. Physiol Res 2014;63 Suppl 1:S237-S249.
  17. Toussaint M, Luthringer R, Staner L, Muzet A, Macher J. Changes in EEG power density during sleep laboratory adaptation in depressed inpatients. Biol Psychiatry 2000;47:626-633. https://doi.org/10.1016/S0006-3223(99)00161-4