생약학회지 (Korean Journal of Pharmacognosy)

  • 제49권2호
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  • Pages.165-171
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  • 2018
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Franz Diffusion Cell을 이용한 인진호 함유 경피제의 피부투과 특성 연구

Permeation Characteristics of Transdermal Preparations Containing Artemisiae Capillaris Herba in Franz Diffusion Cell

  • 김은남 (계명대학교 약학대학) ;
  • 박교현 (계명대학교 자연과학대학) ;
  • 김배환 (계명대학교 자연과학대학) ;
  • 정길생 (계명대학교 약학대학)
  • 투고 : 2018.05.31
  • 심사 : 2018.06.23
  • 발행 : 2018.06.30
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초록

Artemisiae Capillaris Herba is a dried aerial part of Asteraceae capillaris Thunb.(Compositae), which has been used in Korean traditional medicine for the treatment of various diseases. It has a variety of pharmacological activities and has been evaluated for potential as an active ingredient in cosmeceutical products. In the cosmetics industry, animal experiments is besides the major concern of ethics, there are few more disadvantages of animal experimentation like demand of skilled manpower, time consuming protocols and high cost. Therefore, various alternatives to animal experiments have been proposed. The purpose of this study was to investigate the skin permeation characteristics of chlorogenic acid and dimethyleculetin, which are constituent of Artemisiae Capillaris Herba by using Franz diffusion cell. As a result, skin permeability was characterized by flux(penetration rates) and $K_p$(permeability coefficient) value, chlorogenic acid had lower flux and $K_p$ than dimethylesculetin. According to the definitions of Marzulli, chlorogenic acid and dimethylesculetin would be classified as 'Moderate' and 'Very fast' respectively. In conclusion, skin permeation characteristics of chlorogenic acid and dimethylesculetin were confirmed through Franz diffusion cell, and suggests the direction of alternative method for skin permeation of natural compounds.

키워드

참고문헌

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