생약학회지 (Korean Journal of Pharmacognosy)

  • 제49권2호
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  • Pages.124-131
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  • 2018
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

상륙 추출물의 F344 랫드에서 2주 반복 경구투여 독성평가

Toxicity Assessment of Phytolaccae Radix Aqueous Extract Orally Administered to F344 Rats for Two Consecutive Weeks

  • Han, Hyoung-Yun (College of Veterinary Medicine, Chungnam National University) ;
  • Kang, Myung-Gyun (Korea Institute of Toxicology) ;
  • Yoon, Seokjoo (Korea Institute of Toxicology) ;
  • Seok, Ji-Hyeon (Toxicological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Jeong Ah (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Kim, Tae-Won (College of Veterinary Medicine, Chungnam National University) ;
  • Min, Byung Sun (College of Pharmacy, Drug Research and Development Center, Daegu Catholic University)
  • 투고 : 2018.03.22
  • 심사 : 2018.05.10
  • 발행 : 2018.06.30
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초록

Phytolaccae Radix has long been used as a traditional indigenous medicine to cure edema and rheumatism. However, there is insufficient background information on toxicological evaluation of Phytolaccae Radix extract to support the safe use. Therefore, we conducted a series of standardized, OECD and KFDA guidelines compliant in vivo study, to find a dose levels for the 13 weeks toxicity study. The extract of Phytolaccae Radix was administered orally to F344 rats at dose levels of 0, 500, 1000 and 2000 mg/kg/day for 2 weeks. Each group was composed to five male and five female rats. In the result, there were no test article-related adverse changes in clinical signs, body weight, food consumption, ophthalmology, hematology, clinical chemistry, gross finding at necropsy and organ weight examination. Therefore, we recommend that 2000 mg/kg/day is a highest treatment group in 13-week exposure study.

키워드

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