Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Phytochemical Constituents of Lonicera maackii Stems

괴불나무(Lonicera maackii) 줄기의 성분

  • An, Gye Yeong (College of Pharmacy, Kangwon National University) ;
  • Chung, Sung Woo (College of Pharmacy, Kangwon National University) ;
  • Cho, Hee Chan (College of Pharmacy, Kangwon National University) ;
  • Park, Jin Ryoung (College of Pharmacy, Kangwon National University) ;
  • Kim, Myong Jo (College of Agriculture and Life Science, Kangwon National University) ;
  • Kim, Hyun Pyo (College of Pharmacy, Kangwon National University) ;
  • Yang, Hee Jung (College of Pharmacy, Kangwon National University) ;
  • Chun, Wanjoo (School of Medicine, Kangwon National University, Kangwon National University) ;
  • Kwon, Yongsoo (College of Pharmacy, Kangwon National University)
  • Received : 2018.05.08
  • Accepted : 2018.06.21
  • Published : 2018.06.30
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Abstract

Two phenylpropanoids, three caffeoylquinic acid deravatives and an iridoid were isolated from the stem of Lonicera macckii. On the basis of physico-chemical data, these compounds were identified as caffeic acid methyl ester(1), 5-caffeoylquinic acid n-butyl ester(2), methyl 3,4-dicaffeoyl quinate(3), 3,5-dicaffeoyl quinic acid n-butyl ester(4), loganin (5) and caffeic acid(6). All compounds were isolated for the first time from the stem of this plant.

Keywords

References

  1. 이우철 (1996) 원색 한국기준식물도감, 331, 아카데미서적, 서울.
  2. 배기환 (2000) 한국의 약용식물, 474, 교학사, 서울.
  3. 國家中醫藥管理局 <中華本草> 編纂委員會 (1999) 中華本草 7, 539-540, 上海科學技術出版社, 上海.
  4. Kim, S. M., Won, Y. H., Jeong, K., Kim, M. J., Chun, W., Yang, H. J. and Kwon, Y. (2016) Chemical constituents of Lonicera macckii leaves, Kor. J. Pharmacogn. 47: 117-121.
  5. Chang, S. W., Kim, K. H., Lee, I. K., Choi, S. U., Ryu, S. Y. and Lee, K. R. (2009) Phytochemical Constituents of Bistorta manshuriensis, Nat. Prod. Sci. 15: 234-240.
  6. Vongvanich, N., Kittakoop, P., Charoenchai, P., Intamas, S., Sriklung, K. and Thebtaranonth, Y. (2006) Antiplasmoida, antimycobacterial and cytotoxic principles from Camchaya calcarea. Planta Med. 72: 1427-1430. https://doi.org/10.1055/s-2006-951711
  7. Lee, M. W. (1998) Phenolic compound from Lepisorus thunbergianus. Kor. J. Pharmacogn. 29: 142-145.
  8. Chai, X. Y., Dou, J., He, Q. H. and Li, P. (2004) Studies on the phenolic acid compounds from Lonicera confusa DC. Chin. J. Nat. Med. 2: 339-340.
  9. Suarez-Quiroz, M. L., Campos, A. A., Alfaro, V. G., Gonzalez-Rios, O., Villeneuve, P. and Figueroa-Espinoza, M. C. (2013) Anti-Aspergillus activity of green coffee 5-O-caffeoyl quinic acid and its alkyl esters. Microb. Pathog. 61-62: 51-56. https://doi.org/10.1016/j.micpath.2013.05.005
  10. Rumbero-Sanchez, A. and Vazquez, P. (1991) Quinic acid esters from Isertia haenkeana. Phytochemistry 30: 311-313. https://doi.org/10.1016/0031-9422(91)84144-H
  11. Nishizawa, M., Izuhara, R., Kaneko, K., Koshihara, Y. and Fujimoto, Y. (1988) 5-Lipoxygenase inhibitors isolated from Gardeniae Fructus. Chem. Pharm. Bull. 36: 87-95. https://doi.org/10.1248/cpb.36.87
  12. Basnet, P., Matsushige, K., Hase, K., Kadota, S. and Namba, T. (1996) Potent antihepatotoxic activity of dicaffeoyl quinic acids from Propolis. Biol. Pharm. Bull. 19: 655-657. https://doi.org/10.1248/bpb.19.655
  13. Peng, L. Y., Mei, S. X., Jiang, B., Zhou, H. and Sun, H. D. (2000) Constituents from Lonicera japonica. Fitotherapia 71: 713-715. https://doi.org/10.1016/S0367-326X(00)00212-4
  14. Wei, X., Huang, H., Wu, P., Cao, H. and Ye, W. (2004) Phenolic constituents from Mikania micrantha. Biochem. Syst. Eocol. 32: 1091-1096. https://doi.org/10.1016/j.bse.2004.04.013
  15. Thung, P. T., Su, N. D., Ngoc, T. M., Hung, T. M., Dang, N. H., Thuan, N. D., Bae, K. and Oh, W. K. (2009) Antioxidant acitivity and principles of Vietnam bitter tea Ilex kudingcha. Food Chem. 113: 139-145. https://doi.org/10.1016/j.foodchem.2008.07.041
  16. Alqasoumi, S. I., Al-Rdhaily, A. J. and Abdel-Kader, M. S. (2009) Constituents of the aerial parts of Lonicera etrusca growing in Saudi Arabia. Nat. Prod. Sci. 15: 121-124.
  17. Kwon, Y. S., In, K. G. and Kim, C. M. (2000) Chemical constituents form the roots of Ostericum koreanum. Kor. J. Pharmacogn. 31: 284-287.
  18. Suchaichit, N., Kanokmedhkul, S., Kanokmedhakul, K., Moosophon, P., Boonyarat, C., Plekratoke, K., Tearavarich, R. and Suchaichit, N. P. (2017) Phytochemical investigation and acetylcholinesetease inhibitory activity of bark of Hymenodictyon orixense. Nat. Prod. Res. 19: 1-4.
  19. Xu, Y. D., Cui, C., Sun, M. F., Zhu, Y. L., Chu, M., Shi, Y. W., Lin, S., L., Yang, X. S. and Shen, W. Q. (2017) Neuroprotective effects of loganin on MPTP-induced parkinson's disease mice: neurochemistry, glial reaction nd autophagy studies. J. Cell Biochem. 118: 3495-3510. https://doi.org/10.1002/jcb.26010
  20. Liu, Z. D., Zhao, D. D., Jiang, S., Xue, B., Zhang, Y. L. and Yan, X. F. (2018) Anticancer phenolics from Dryopteris fragrans (L.) Schott. Molecules 23: E680. https://doi.org/10.3390/molecules23030680
  21. Molina-Romo, E. D., Garibay-Escobar, A., Valenzuela-Antel, O., Ruiz-Bustos, E., Martine, J. H., Velazquez, C., Rascon-Valenzuela, L. A. and Robles-Zepeda, R. E. (2018) Antiproliperative and apoptotic activities of the medicinal plant Ziziphus obtusifolia. Pharmacognosy Res. 10: 55-59.
  22. Kirmizibekmez, H., Inan, Y., Reis, R., Sipahi, H., Goren, A. C. and Yesilada, E. (2018) Phenolic comounds from the aerial parts of Clematis viticella L. and their anti-inflammatory activities. Nat. Prod. Res. 12: 1-4.
  23. Mitani, T., Ota, K., Inaba, N., Kishida, K. and Koyama, H. A. (2018) Antimicrobial activity of the phenolic compounds of Prunus mume against enterobacteria. Biol. Pharm. Bull. 41: 208-212. https://doi.org/10.1248/bpb.b17-00711
  24. Yen, G. C., Chen, C. S., Chang, W. T., Wu, M. F., Cheng, F. T., Shiau, D. K. and Hsu, C. L. (2018) Antioxidant activity and anticancer effect of ethanolic and aqueous extracts of the roots of Ficus beecheyana and their phenolic components. J. Food Drug Anal. 26: 182-189. https://doi.org/10.1016/j.jfda.2017.02.002