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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Mitochondria-mediated defense mechanisms against pathogens in Caenorhabditis elegans

  • Kwon, Sujeong (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Kim, Eun Ji E. (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Lee, Seung-Jae V. (Department of Life Sciences, Pohang University of Science and Technology)
  • Received : 2018.04.26
  • Published : 2018.06.30
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Abstract

Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response ($UPR^{mt}$), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals.

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