Journal of Dental Anesthesia and Pain Medicine

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of preemptive intravenous ibuprofen on postoperative edema and trismus in third molar tooth extraction: A randomized controlled study

  • Gulnahar, Yakup (Oral and Maxillofacial Surgery Department, Erzincan University) ;
  • Kupeli, Ilke (Anesthesiology and Reanimation Department, Erzincan University)
  • Received : 2018.04.25
  • Accepted : 2018.06.01
  • Published : 2018.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: This study aimed to evaluate the anti-inflammatory efficacy of preemptive intravenous ibuprofen on inflammatory complications such as edema and trismus in patients undergoing impacted mandibular third molar surgery. Methods: Sixty patients were included and divided into three groups (800 mg IV ibuprofen + 50 mg dexketoprofen, 800 mg IV ibuprofen, and control). In all patients, preoperative hemodynamic values were recorded before the infusions. The operation was started at 15-min post-infusion. Evaluation of edema size on the face and mouth opening (trismus) was conducted in the preoperative period, and at postoperative 48 h and 1 week. Results: No difference was determined among the groups in trismus and edema size in postoperative measurements (P > 0.05). There was a difference between group 2 and group 3 only in measurement value of tragus-corner of the mouth on the postoperative day 2 (P < 0.05). A difference was found between the measurement values of trismus preoperatively and at preoperative day 2, and between postoperative day 2 and 1 week in group 3 based on time (P < 0.05). In group 3, edema on the face on postoperative day 2 increased significantly compared to that in the preoperative period (P < 0.001); in addition, edema increased significantly in groups 1 and 2 in the postoperative period but was less than that in group 3 (P < 0.001). Conclusions: In this study, intravenous ibuprofen was determined to be more effective alone or in combination in alleviating trismus and to better limit the postoperative edema.

Keywords

References

  1. Jerjes W, El-Maaytah M, Swinson B, Banu B, Upile T, D'Sa S, et al. Experience versus complication rate in third molar surgery. Head Face Med 2006; 2: 14. https://doi.org/10.1186/1746-160X-2-14
  2. Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am 2007; 19: 117-28, vii. https://doi.org/10.1016/j.coms.2006.11.013
  3. Sato FR, Asprino L, de Araujo DE, de Moraes M. Short-term outcome of postoperative patient recovery perception after surgical removal of third molars. J Oral Maxillofac Surg 2009; 67: 1083-91. https://doi.org/10.1016/j.joms.2008.09.032
  4. Chukwuneke F, Onyejiaka N. Management of postoperative morbidity after third molar surgery: a review of the literature. Niger J Med 2007; 16: 107-12.
  5. Colorado-Bonnin M, Valmaseda-Castellon E, Berini-Aytes L, Gay-Escoda C. Quality of life following lower third molar removal. Int J Oral Maxillofac Surg 2006; 35: 343-7. https://doi.org/10.1016/j.ijom.2005.08.008
  6. Vegas-Bustamante E, Mico-Llorens J, Gargallo-Albiol J, Satorres-Nieto M, Berini-Aytes L, Gay-Escoda C. Efficacy of methylprednisolone injected into the masseter muscle following the surgical extraction of impacted lower third molars. Int J Oral Maxillofac Surg 2008; 37: 260-3. https://doi.org/10.1016/j.ijom.2007.07.018
  7. Chukwuneke FN, Oji C, Saheeb DB. A comparative study of the effect of using a rubber drain on postoperative discomfort following lower third molar surgery. Int J Oral Maxillofac Surg 2008; 37: 341-4. https://doi.org/10.1016/j.ijom.2007.11.016
  8. Markovic A, Todorovic L. Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. Int J Oral Maxillofac Surg 2007; 36: 226-9. https://doi.org/10.1016/j.ijom.2006.10.006
  9. Jain N, Maria A. Randomized double blind comparative study on the efficacy of Ibuprofen and aceclofenac in controlling post-operative sequelae after third molar surgery. J Maxillofac Oral Surg 2011; 10: 118-22. https://doi.org/10.1007/s12663-011-0198-9
  10. Gago Martinez A, Escontrela Rodriguez B, Planas Roca A, Martinez Ruiz A. Intravenous Ibuprofen for Treatment of Post-Operative Pain: A Multicenter, Double Blind, Placebo-Controlled, Randomized Clinical Trial. PLoS One 2016; 11: e0154004. https://doi.org/10.1371/journal.pone.0154004
  11. Southworth S, Peters J, Rock A, Pavliv L. A multicenter, randomized, double-blind, placebo- controlled trial of intravenous ibuprofen 400 and 800 mg every 6 hours in the management of postoperative pain. Clin Ther 2009; 31: 1922-35. https://doi.org/10.1016/j.clinthera.2009.08.026
  12. Agarwal S, Chattopadhyay S, Mandal M, Bengal W. Comparison of efficacy of aceclofenac and ibuprofen after surgical removal of impacted third molar. J Evol Med Dent Sci 2017; 6: 1670-7. https://doi.org/10.14260/Jemds/2017/368
  13. Silvestri AR Jr, Singh I. The unresolved problem of the third molar: would people be better off without it? J Am Dent Assoc 2003; 134: 450-5. https://doi.org/10.14219/jada.archive.2003.0194
  14. Osunde OD, Saheeb BD. Effect of age, sex and level of surgical difficulty on inflammatory complications after third molar surgery. J Maxillofac Oral Surg 2015; 14: 7-12.
  15. Troullos ES, Hargreaves KM, Butler DP, Dionne RA. Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. J Oral Maxillofac Surg 1990; 48: 945-52. https://doi.org/10.1016/0278-2391(90)90007-O
  16. Savage MG, Henry MA. Preoperative nonsteroidal antiinflammatory agents: Review of the literature. Oral Surg Oral Med Oral Pathol Oral Rad Endod 2004; 98: 146-52. https://doi.org/10.1016/j.tripleo.2004.01.012
  17. Seymour RA, Frame J, Negus TW, Hawkesford JE, Marsden J, Matthew IR. The comparative efficacy of aceclofenac and ibuprofen in postoperative pain after third molar surgery. Br J Oral Maxillofac Surg 1998; 36: 375-9. https://doi.org/10.1016/S0266-4356(98)90650-7
  18. Vogel RI, Desjardins PJ, Major KV. Comparison of presurgical and immediate postsurgical ibuprofen on postoperative periodontal pain. J Periodontol 1992; 63: 914-8. https://doi.org/10.1902/jop.1992.63.11.914
  19. McQuay HJ, Carroll D, Guest PG, Robson S, Wiffen PJ, Juniper RP. A multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery. Br J Oral Maxillofac Surg 1993; 31: 95-100. https://doi.org/10.1016/0266-4356(93)90169-W
  20. Averbuch M, Katzper M. Severity of baseline pain and degree of analgesia in the third molar post-extraction dental pain model. Anesth Analg 2003; 97: 163-7, table of contents.
  21. Morse Z, Tump A, Kevelham E. Ibuprofen as a preemptive analgesic is as effective as rofecoxib for mandibular third molar surgery. Odontology 2006; 94: 59-63. https://doi.org/10.1007/s10266-006-0062-4
  22. Miranda HF, Sierralta F, Prieto JC. Synergism between NSAIDs in the orofacial formalin test in mice. Pharmacol Biochem Behav 2009; 92: 314-8. https://doi.org/10.1016/j.pbb.2008.12.018

Cited by

  1. Preemptive use of intravenous ibuprofen to reduce postoperative pain after lower third molar surgery: a systematic review of randomized controlled trials vol.76, pp.None, 2018, https://doi.org/10.6061/clinics/2021/e2780
  2. Pre-emptive analgesic efficacy of injected ketorolac in comparison to other agents for third molar surgical removal: a systematic review vol.21, pp.1, 2018, https://doi.org/10.17245/jdapm.2021.21.1.1