Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Mitochondrial tumor suppressor 1 is a target of AT-rich interactive domain 1A and progesterone receptor in the murine uterus

  • Chang, Hye Jin (Obstetrics, Gynecology & Reproductive Biology, Michigan State University) ;
  • Teasley, Hanna E. (Obstetrics, Gynecology & Reproductive Biology, Michigan State University) ;
  • Yoo, Jung-Yoon (Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine) ;
  • Kim, Tae Hoon (Obstetrics, Gynecology & Reproductive Biology, Michigan State University) ;
  • Jeong, Jae-Wook (Obstetrics, Gynecology & Reproductive Biology, Michigan State University)
  • Received : 2017.12.30
  • Accepted : 2018.03.29
  • Published : 2018.08.01
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Abstract

Objective: Progesterone receptor (PGR) and AT-rich interactive domain 1A (ARID1A) have important roles in the establishment and maintenance of pregnancy in the uterus. In present studies, we examined the expression of mitochondrial tumor suppressor 1 (MTUS1) in the murine uterus during early pregnancy as well as in response to ovarian steroid hormone treatment. Methods: We performed quantitative reverse transcription polymerase chain reaction and immunohistochemistry analysis to investigate the regulation of MTUS1 by ARID1A and determined expression patterns of MTUS1 in the uterus during early pregnancy. Results: The expression of MTUS1 was detected on day 0.5 of gestation (GD 0.5) and then gradually increased until GD 3.5 in the luminal and glandular epithelium. However, the expression of MTUS1 was significantly reduced in the uterine epithelial cells of $Pgr^{cre/+}Arid1a^{f/f}$ and Pgr knockout (PRKO) mice at GD 3.5. Furthermore, MTUS1 expression was remarkably induced after P4 treatment in the luminal and glandular epithelium of the wild-type mice. However, the induction of MTUS1 expression was not detected in uteri of $Pgr^{cre/+}Arid1a^{f/f}$ or PRKO mice treated with P4. Conclusion: These results suggest that MTUS1 is a novel target gene by ARID1A and PGR in the uterine epithelial cells.

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References

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