Clinical Nutrition Research

  • 제7권2호
  • /
  • Pages.126-135
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  • 2018
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  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
권호 표지
DOI QR코드

DOI QR Code

Hypouricemic Effect of Ethanol Extract of Aster glehni Leaves in Potassium Oxonate-Induced Hyperuricemic Rats

  • Park, Ji-Eun (Department of Public Health Science (Brain Korea 21 PLUS Program), Graduate School, Korea University) ;
  • Yeom, Zia (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) ;
  • Park, Keun-Tae (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) ;
  • Han, Eun Hye (Department of R&D, Koreaeundan Co.) ;
  • Yu, Heui Jong (Bioland Co. Ltd.) ;
  • Kang, Hyo Seok (Bioland Co. Ltd.) ;
  • Lim, Young-Hee (Department of Public Health Science (Brain Korea 21 PLUS Program), Graduate School, Korea University)
  • 투고 : 2018.03.31
  • 심사 : 2018.04.16
  • 발행 : 2018.04.30
⟨ 이전 논문 다음 논문 ⟩

초록

The prevalence of gout is increasing worldwide, and control of serum uric acid level has been regarded as one of the therapeutic methods for gout. Inhibition of xanthine oxidase (XO) activity which can oxidize hypoxanthine to uric acid has been commonly proposed to decrease serum uric acid level. The aim of this study was to demonstrate the hypouricemic effect of ethanol extract of Aster glehni leaves (EAG) by in vitro and in vivo study in potassium oxonate (PO)-induced hyperuricemic rats. EAG possessed $132.5{\pm}6.8mgQE/g$ of total flavonoid and showed antioxidant activity. EAG showed in vitro and in vivo inhibitory activity against XO and significantly decreased serum uric acid level in PO-induced hyperuricemic rats without liver toxicity. These results show that EAG significantly attenuates hyperuricemia by inhibiting XO activity, which resulted in the decrease of serum uric acid level. Therefore, EAG might possess a potential therapeutic ability for improving gout.

키워드

과제정보

연구 과제 주관 기관 : Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET)

참고문헌

  1. Rock KL, Kataoka H, Lai JJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol 2013;9:13-23. https://doi.org/10.1038/nrrheum.2012.143
  2. Huang J, Wang S, Zhu M, Chen J, Zhu X. Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice. Food Chem Toxicol 2011;49:1943-7. https://doi.org/10.1016/j.fct.2011.04.029
  3. Perez-Ruiz F, Liote F. Lowering serum uric acid levels: what is the optimal target for improving clinical outcomes in gout? Arthritis Rheum 2007;57:1324-8. https://doi.org/10.1002/art.23007
  4. Lin KC, Lin HY, Chou P. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J Rheumatol 2000;27:1501-5.
  5. Fels E, Sundy JS. Refractory gout: what is it and what to do about it? Curr Opin Rheumatol 2008;20:198-202. https://doi.org/10.1097/BOR.0b013e3282f4eff5
  6. Li H, Zhao M, Su G, Lin L, Wang Y. Effect of soy sauce on serum uric acid levels in hyperuricemic rats and identification of flazin as a potent xanthine oxidase inhibitor. J Agric Food Chem 2016;64:4725-34. https://doi.org/10.1021/acs.jafc.6b01094
  7. Murugaiyah V, Chan KL. Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. J Ethnopharmacol 2009;124:233-9. https://doi.org/10.1016/j.jep.2009.04.026
  8. Wang WL, Sheu SY, Huang WD, Chuang YL, Tseng HC, Hwang TS, Fu YT, Kuo YH, Yao CH, Kuo TF. Phytochemicals from tradescantia albiflora kunth extracts reduce serum uric acid levels in oxonate-induced rats. Pharmacogn Mag 2016;12:S223-7. https://doi.org/10.4103/0973-1296.182171
  9. Wang M, Zhao J, Zhang N, Chen J. Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice. Biomed Pharmacother 2016;83:975-88. https://doi.org/10.1016/j.biopha.2016.07.025
  10. Lee HM, Yang G, Ahn TG, Kim MD, Nugroho A, Park HJ, Lee KT, Park W, An HJ. Antiadipogenic effects of Aster glehni extract: in vivo and in vitro effects. Evid Based Complement Alternat Med 2013;2013:859624.
  11. Samatha T, Shyamsundarachary R, Srinivas P, Swamy NR. Quantification of total phenolic and total flavonoid contents in extracts of Oroxylum indicum L.Kurz. Asian J Pharm Clin Res 2012;5:177-9.
  12. Pontis JA, Costa LA, Silva SJ, Flach A. Color, phenolic and flavonoid content, and antioxidant activity of honey from Roraima, Brazil. Food Sci Technol (Campinas) 2014;34:69-73. https://doi.org/10.1590/S0101-20612014005000015
  13. Liu LM, Cheng SF, Shieh PC, Lee JC, Chen JJ, Ho CT, Kuo SC, Kuo DH, Huang LJ, Way TD. The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats. Food Chem Toxicol 2014;70:179-84. https://doi.org/10.1016/j.fct.2014.05.004
  14. Azmi SM, Jamal P, Amid A. Xanthine oxidase inhibitory activity from potential Malaysian medicinal plant as remedies for gout. Int Food Res J 2012;19:59-66.
  15. Liu K, Wang W, Guo BH, Gao H, Liu Y, Liu XH, Yao HL, Cheng K. Chemical evidence for potent xanthine oxidase inhibitory activity of ethyl acetate extract of Citrus aurantium L. dried immature fruits. Molecules 2016;21:302. https://doi.org/10.3390/molecules21030302
  16. Jang IT, Hyun SH, Shin JW, Lee YH, Ji JH, Lee JS. Characterization of an anti-gout xanthine oxidase inhibitor from Pleurotus ostreatus. Mycobiology 2014;42:296-300. https://doi.org/10.5941/MYCO.2014.42.3.296
  17. Haidari F, Rashidi MR, Keshavarz SA, Mahboob SA, Eshraghian MR, Shahi MM. Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats. Pak J Biol Sci 2008;11:1779-84. https://doi.org/10.3923/pjbs.2008.1779.1784
  18. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 1976;72:248-54. https://doi.org/10.1016/0003-2697(76)90527-3
  19. Fukumoto LR, Mazza G. Assessing antioxidant and prooxidant activities of phenolic compounds. J Agric Food Chem 2000;48:3597-604. https://doi.org/10.1021/jf000220w
  20. Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000;63:1035-42. https://doi.org/10.1021/np9904509
  21. Calitz C, du Plessis L, Gouws C, Steyn D, Steenekamp J, Muller C, Hamman S. Herbal hepatotoxicity: current status, examples, and challenges. Expert Opin Drug Metab Toxicol 2015;11:1551-65. https://doi.org/10.1517/17425255.2015.1064110
  22. Huang XJ, Choi YK, Im HS, Yarimaga O, Yoon E, Kim HS. Aspartate aminotransferase (AST/GOT) and alanine aminotransferase (ALT/GPT) detection techniques. Sensors (Basel) 2006;6:756-82. https://doi.org/10.3390/s6070756
  23. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006;440:237-41. https://doi.org/10.1038/nature04516
  24. Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN, Knott SA, Kolcic I, Polasek O, Graessler J, Wilson JF, Marinaki A, Riches PL, Shu X, Janicijevic B, Smolej-Narancic N, Gorgoni B, Morgan J, Campbell S, Biloglav Z, Barac-Lauc L, Pericic M, Klaric IM, Zgaga L, Skaric-Juric T, Wild SH, Richardson WA, Hohenstein P, Kimber CH, Tenesa A, Donnelly LA, Fairbanks LD, Aringer M, McKeigue PM, Ralston SH, Morris AD, Rudan P, Hastie ND, Campbell H, Wright AF. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 2008;40:437-42. https://doi.org/10.1038/ng.106
  25. Becker MA, Schumacher HR, Wortmann RL, MacDonald PA, Eustace D, Palo WA, Streit J, Joseph-Ridge N. Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005;353:2450-61. https://doi.org/10.1056/NEJMoa050373
  26. Son MJ, Jin C, Lee YS, Lee JY, Kim HJ. Characterization of caffeoylglucoside derivatives and hypouricemic activity of the ethyl acetate fraction from Aster glehni. Bull Korean Chem Soc 2015;36:503-12.
  27. Duni A, Liakopoulos V, Rapsomanikis KP, Dounousi E. Chronic kidney disease and disproportionally increased cardiovascular damage: does oxidative stress explain the burden? Oxid Med Cell Longev 2017;2017:9036450.
  28. Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J, Dagenais GRHOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-47. https://doi.org/10.1001/jama.293.11.1338

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