Clinical Nutrition Research

The Korean Society of Clinical Nutrition (한국임상영양학회)
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Hypouricemic Effect of Ethanol Extract of Aster glehni Leaves in Potassium Oxonate-Induced Hyperuricemic Rats

  • Park, Ji-Eun (Department of Public Health Science (Brain Korea 21 PLUS Program), Graduate School, Korea University) ;
  • Yeom, Zia (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) ;
  • Park, Keun-Tae (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) ;
  • Han, Eun Hye (Department of R&D, Koreaeundan Co.) ;
  • Yu, Heui Jong (Bioland Co. Ltd.) ;
  • Kang, Hyo Seok (Bioland Co. Ltd.) ;
  • Lim, Young-Hee (Department of Public Health Science (Brain Korea 21 PLUS Program), Graduate School, Korea University)
  • Received : 2018.03.31
  • Accepted : 2018.04.16
  • Published : 2018.04.30
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Abstract

The prevalence of gout is increasing worldwide, and control of serum uric acid level has been regarded as one of the therapeutic methods for gout. Inhibition of xanthine oxidase (XO) activity which can oxidize hypoxanthine to uric acid has been commonly proposed to decrease serum uric acid level. The aim of this study was to demonstrate the hypouricemic effect of ethanol extract of Aster glehni leaves (EAG) by in vitro and in vivo study in potassium oxonate (PO)-induced hyperuricemic rats. EAG possessed $132.5{\pm}6.8mgQE/g$ of total flavonoid and showed antioxidant activity. EAG showed in vitro and in vivo inhibitory activity against XO and significantly decreased serum uric acid level in PO-induced hyperuricemic rats without liver toxicity. These results show that EAG significantly attenuates hyperuricemia by inhibiting XO activity, which resulted in the decrease of serum uric acid level. Therefore, EAG might possess a potential therapeutic ability for improving gout.

Keywords

Acknowledgement

Supported by : Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET)

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