Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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An Experimental Study on Acute Toxicity of Benzo[a]pyrene

벤조피렌의 급성독성시험 연구

  • Kim, Mina (Department of Chemical Engineering & Biotechnology, Korea Polytechnic University) ;
  • Lee, Seungkil (Department of Environment and Public Health, Jangan University) ;
  • Cho, Samrae (Korea Chemical Management Association) ;
  • Kim, Dukhyun (Department of Chemical Engineering & Biotechnology, Korea Polytechnic University)
  • Received : 2018.03.04
  • Accepted : 2018.03.26
  • Published : 2018.03.30
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Abstract

Objectives: This study was performed to observe the toxicological changes caused by a single exposure to benzo[a]pyrene. Methods: Based on the results of a preliminary study, 300 mg/kg was set as the middle dose. A highest dose of 2,000 mg/kg and a lowest dose of 50 mg/kg were selected based on GHS guidelines. Benzo[a]pyrene was orally administered once to female and male SD rats at dose levels of 50, 300, and 2,000 mg/kg(body weight). All animals were monitored daily for clinical signs and mortality over 14 days. Hematological and biochemical values were examined as well. Results: There were neither dead animals nor significant changes in body weights during the experimental period. In addition, no differences were found between the control and treated groups in clinical sign, hematology, serum biochemical, and histopathological analysis. Conclusion: Compared with the control group, we could not detect any toxic alteration in all treated groups. These studies indicate that the acute toxicity of benzo[a]pyrene is relatively low.

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References

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