Allergy, Asthma & Respiratory Disease

  • 제6권1호
  • /
  • Pages.72-76
  • /
  • 2018
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  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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길랭-바레증후군과 유사한 급성다발신경병증을 보인 호산구육아종증 1예

Eosinophilic granulomatosis with polyangiitis presenting with acutepolyneuropathy mimicking Guillain-Barré syndrome: A case report

  • 김지선 (영남대학교 의과대학 내과학교실) ;
  • 안준홍 (영남대학교 의과대학 내과학교실) ;
  • 진현정 (영남대학교 의과대학 내과학교실)
  • Kim, Jee Seon (Department of Internal Medicine, Yeungnam University College of Medicine) ;
  • Ahn, June Hong (Department of Internal Medicine, Yeungnam University College of Medicine) ;
  • Jin, Hyun Jung (Department of Internal Medicine, Yeungnam University College of Medicine)
  • 투고 : 2017.07.22
  • 심사 : 2017.08.30
  • 발행 : 2018.01.31
⟨ 이전 논문 다음 논문 ⟩

초록

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis that commonly affects the peripheral nervous system. EGPA rarely presents with acute polyneuropathy resembling $Guillain-Barr{\acute{e}}$ syndrome (GBS). A 51-year-old female patient with a history of asthma suddenly developed bilateral lower extremityparesthesia that progressed to asymmetric ascending paralysis within 10 days of onset. Nerve conduction study results were compatible with acute motor sensory axonal neuropathy, consistent with a GBS subtype. A clinical and neurophysiological diagnosis of GBS was made, and high-dose intravenous immunoglobulins were administered. However, the patient's painful motor weakness persisted. Furthermore, she had newly developed skin lesions on her back, face, and arms. Her blood test revealed marked eosinophilia (> 60%). In addition, antineutrophil cytoplasmic antibodies were reported positive. A Water's view radiographic image showed bilateral maxillary sinusitis. Considering the history of asthma, we suspected EGPA-associated polyneuropathy and started steroid treatment. The patient's strength and eosinophilia improved rapidly and dramatically. EGPA can mimic GBS and should be differentiated because of different treatment strategies. Early diagnosis and prompt treatment help achieve a good outcome.

키워드

참고문헌

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