Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Successful desensitization to fluconazole induced delayed hypersensitivity: A case report

Fluconazole 지연형 과민반응에 대한 성공적인 탈감작 사례 1예

  • Heo, Yeon-Jeong (Department of Internal Medicine, Kangwon National University Hospital) ;
  • Park, Seung-Woo (Department of Internal Medicine, Kangwon National University Hospital) ;
  • Lee, Kyu-Sun (Department of Internal Medicine, Kangwon National University Hospital) ;
  • Kang, Hye-Ryun (Department of Internal Medicine, Seoul National University Hospital) ;
  • Kwon, Jae-Woo (Department of Internal Medicine, Kangwon National University Hospital)
  • Received : 2017.04.15
  • Accepted : 2017.09.08
  • Published : 2018.01.31
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Abstract

Fluconazole is a triazole-based first-generation antifungal agent and has excellent effects on candidiasis and cryptococcosis. Hypersensitivity has been reported as a side effect of fluconazole. A 76-year-old female patient used fluconazole for consolidation therapy for cryptococcal meningitis, but showed delayed hypersensitivity with skin rashes and itching sensation of the whole body. For desensitization, was attempted by administering 12-step, 1:1 fluconazole solutions were administered intravenously at sequentially increasing infusion rates. After successful quick desensitization to fluconazole, fluconazole was continuously used as a consolidation therapy for cryptococcal meningitis. We herein report a case of delayed hypersensitivity reaction to fluconazole in consolidation therpy with cryptococcal meningitis who successfully completed desensitization.

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References

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