Allergy, Asthma & Respiratory Disease

The Korean Academy of Asthma, Allergy and Clinical Immunology (대한천식알레르기학회)
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Bronchiolitis severity according to the infected viruses

급성모세기관지염의 원인 바이러스에 따른 중증도 차이

  • Lee, Su Jin (Department of Pediatrics, Dongguk University Ilsan Hospital) ;
  • Park, Sang Kyu (Department of Pediatrics, Dongguk University Ilsan Hospital) ;
  • Kim, Ji Hyun (Department of Pediatrics, Dongguk University Ilsan Hospital) ;
  • Cho, Sung Min (Department of Pediatrics, Dongguk University Ilsan Hospital)
  • 이수진 (동국대학교 일산병원 소아청소년과) ;
  • 박상규 (동국대학교 일산병원 소아청소년과) ;
  • 김지현 (동국대학교 일산병원 소아청소년과) ;
  • 조성민 (동국대학교 일산병원 소아청소년과)
  • Received : 2017.03.10
  • Accepted : 2017.10.24
  • Published : 2018.01.31
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Abstract

Purpose: The aim of this study was to evaluate the severity of disease in children with acute bronchiolitis according to the type of infected virus. Methods: From November 2007 to May 2015, 768 patients under 2 years of age who underwent real time-polymerase chain reaction of nasopharyngeal aspirates admitted to the Department of Pediatrics of Dongguk University Ilsan Hospital for acute bronchiolitis were enrolled. Severe bronchiolitis was defined as presence of one or more kinds among tachypnea, chest retraction, needs of $O_2$ inhalation or ventilator care. Results: The severity of bronchiolitis was increased with shorter fever duration (P< 0.001) and previous wheezing episodes (P= 0.005). In the case of single infection, respiratory syncytial virus (RSV) A only increased the severity of acute bronchiolitis (P= 0.012). However, the severity of illness decreased when RSV A coinfected with adenovirus (P= 0.034), human rhinovirus (P= 0.038), or human coronavirus NL63 (P= 0.042). On the other hand, when human rhinovirus was coinfected with enterovirus (P= 0.013) or parainfluenza 3 (P= 0.019), the severity was increased. When human metapneumovirus coinfected with human bocavirus, the severity was increased (P= 0.038). Conclusion: Acute bronchiolitis was associated with increased severity only when RSV A infected solely, but several viruses increased or decreased the severity when coinfection occurred. Therefore, it may be helpful in predicting the course of the acute bronchiolitis according to the affected virus.

Keywords

References

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